Term
| alpha andrenergic receptors |
|
Definition
vasoconstriction
dilation of iris
platelet aggregation
can increase BP |
|
|
Term
| beta andrenergic receptors |
|
Definition
vasodilation
increase HR
increase strength of heartbeat B1
Lipolysis B1
Glycogenolysis
Bronchodilation |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
alpha antagonist
derived from a fungus, ex. imitrax |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
NE release facilitator
brochodilator, weight loss agent, increase concentration |
|
|
Term
|
Definition
|
|
Term
|
Definition
NE release facilitator
product of fermentation, mainly a decarboxylation of tyrosine |
|
|
Term
|
Definition
| constrict blood vessels, decongestant |
|
|
Term
| What are the dopamine receptors? |
|
Definition
Muscarinic receptors
D1 & D5
D2, D3, D4 |
|
|
Term
|
Definition
|
|
Term
|
Definition
| increase permeability of calcium |
|
|
Term
|
Definition
most widespread
present in caudate putamen, striatum, acumbens, LS |
|
|
Term
|
Definition
inhibitory
Gi
mostly by increase permeability to K+ |
|
|
Term
|
Definition
| mostly in neocortex, especially amygdala hippocampus, hypothalamus |
|
|
Term
|
Definition
|
|
Term
Antipsychotic
DA antagonist
Clozapine |
|
Definition
|
|
Term
|
Definition
blocks reuptake of dopamine and serotonin
blocks Na channels, potent vasoconstrictor |
|
|
Term
|
Definition
increase release of dopamine
decrease fatigue, appetite
increase alertness |
|
|
Term
|
Definition
more powerful
high addiction risk
added to caffeine = Kamikaze |
|
|
Term
|
Definition
inhibits the reuptake of dopamine and increases its release
doesn't produce euphoria |
|
|
Term
|
Definition
| increase release of dopamine |
|
|
Term
| decreased 5HT and increase NE = |
|
Definition
|
|
Term
| decreased 5HT and decreased NE = |
|
Definition
|
|
Term
|
Definition
antidepressant
blocks breakdown of enzyme |
|
|
Term
|
Definition
blocks reuptake of 5HT
antidepressant |
|
|
Term
|
Definition
reuptake is inhibited
blocks histamine and Ach
antidepressant |
|
|
Term
| How is serotonin produced? |
|
Definition
| Tryptophan + Tryptophan Hydrolase = 5 hydroxytryptophan + decarboxylase = 5-HT |
|
|
Term
| How many families of 5HT are there? |
|
Definition
|
|
Term
| Which 5HTs are inhibitory? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Which 5HT is targeted by antidepressants? |
|
Definition
|
|
Term
| Which 5HT increases halucinations? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
derived from ergot
5HT agonist |
|
|
Term
| The major excititory NT in the brain? |
|
Definition
|
|
Term
| What are the ionotropic glutamate receptors? |
|
Definition
|
|
Term
| What blocks the NMDA channels? |
|
Definition
|
|
Term
|
Definition
derived from amanita m
Glutamate agonist |
|
|
Term
|
Definition
|
|
Term
|
Definition
Glutatmate agonist
in chick peas |
|
|
Term
|
Definition
|
|
Term
| The major inhibitory NT in the brain? |
|
Definition
|
|
Term
|
Definition
| decarboxylation of glutamate by enzyme GAD |
|
|
Term
| What is the metabotropic receptor for GABA? |
|
Definition
| GABAb it increases the permeability of K+ |
|
|
Term
| What is the ionotropic receptor for GABA? |
|
Definition
| GABAa increases the permeability of cholride in |
|
|
Term
|
Definition
GABA agonist
makes it easier for GABAa to bind
causes drowsiness, dizziness, decreases alertness, produces HTN |
|
|
Term
| Where is the BZD binding site? |
|
Definition
| between gamma 2 and alpha 1 |
|
|
Term
|
Definition
GABA agonist
increase duration Cl channel is open for GABAa and it opens the Cl channels
increases anxiety
binds to alpha 1 |
|
|
Term
|
Definition
GABA agonist
enhances GABAa
ex. Mickies (date rape drug) |
|
|
Term
| Where is the GABA binding site? |
|
Definition
| Between alpha 1 and beta 2 needs to be 2 present |
|
|
Term
|
Definition
GABA agonist
binds to GABAa receptors increases action
calmness, increase alertness
decreases NMDAs responsiveness
release beta endorphins
cause release of DA esp from VTA |
|
|
Term
|
Definition
GABA agonist
enhances GABA |
|
|
