• half-life: 30-60min (longest of the curares)
• MoA: non-depolarizing blockade of muscle nic recs (curare)
• Elim: renal excretion
• Rx: adjuvant in surgical anesthesia, abdom wall relax & orthopedic procedures
• tox: non-analgesic, apnea
• contras: 

- cholinesterase inhibitors (neostigmine)

- muscarinic blockers (glycopyrrolate--minimizes muscarinic effects of cholinesterase inhibitors)

• half-life: >60min
• MoA: non-depol blockade of muscle nic receptors (curare)
• Elim: liver and renal
• Rx: prototype (only used in lethal injection)
• tox: 
• contras: 

• half-life: 25-60min (medium of curares)
• MoA: non-depol blockade of muscular nic receptors (curare)
• Elim: liver
• Rx: intubation, muscle relaxation during surgery or ventillation
• tox: apnea, non-analgesic
• contras: 

• half-life: 15-20min (shortest of curares)
• MoA: non-depol blockade of muscle nic recs (curare)
• Elim: plasma cholinesterase!!
• Rx: intubation, muscle relax during surgery or vent in pts w renal failure!!
• tox: apnea, non-anagesic
• contras: 

• half-life: 30-45min (medium for curares)
• MoA: non-depol blockade of muscle nic recs (curare)
• Elim: liver, renal
• Rx: adjuvant in surgical anesthesia, abdom wall relax & orthopedic procedures
• tox: apnea, non-analgesic
• contras: 

• half-life: <8min (SHORT!!)
• MoA: nic agonist--depolarization blockade of muscle nic receptors 
• Elim: plasma cholinesterase--(not AchE)
• Rx: tracheal intubation, control convulsions during ECT
• tox: apnea, non-analgesic, muscle pain from fasciculations, can initiate malignant hyperthermia
• contras: malignant hyperthermia

phase I: depolarizing block. inactivation of volt-gated Na+ channels.

antidote: none (hydrolyzed in 5-10min)

--Atropine for bradycardia due to muscarinic effects

phase II: desensitization block (if succinylcholine left for >30min, the neuron will be desensitized even after succinylcholine dissociates)

antidote: cholinesterase inhibitor!

• half-life: 
• MoA: inhibits NT release from sk muscle sensory afferent (GABAb agonist--spasmolytic)
• Elim: 
• Rx: muscle spasticity assoc w MS or spinal cord injury
• tox: heavy drowsiness
• contras: 

• trade: 
• half-life: 
• MoA: facilitate GABA mediated pre-synaptic inhibition
• Elim: 
• Rx: spasticity, MS
• tox: sedation and drowsiness (much less than baclofen)
• contras: 

• half-life: 
• MoA: centrally acting a2 agonist
• Elim: 
• Rx: muscle spasticity, MS
• tox: drowsiness, hypoTN
• contras: 

• half-life: 
• MoA: uncouples excitation-contraction of sk muscles (blocks ryanodine recs--blocks Ca release from SR)
• Elim: 
• Rx: muscle spasm, MALIGNANT HYPERTHERMIA
• tox: muslce weakness, sedation
• contras: