Term
| What is the site of sensory transduction in olfaction? |
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Definition
| The cilia of olfactory receptor neurons |
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Term
| What allows the cilia of olfactory receptor neurons to perform sensory transduction? |
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Definition
| Olfactory receptor proteins |
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Term
| True or false: odorant receptor proteins are G-protein coupled. |
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Definition
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Term
| What superfamily do the receptor proteins in olfaction belong to? |
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Definition
| The same superfamily as metabotropic neurotransmitter receptors. |
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Term
| What activates the Golf (G olfactory) protein? |
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Definition
| Odorant binding to receptor protein |
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Term
| What does Golf stimulate? What is the result of this stimulation? |
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Definition
Adenylyl cyclase
Rise in cAMP levels |
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Term
| What does cAMP stimulate in olfaction? |
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Definition
| the opening of cyclic nucleotide gated ion channels (CNG channels) |
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Term
What type(s) of ions are CNG channels permeable to?
What does the inward current of these ions create? |
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Definition
Both Na+ and Ca2+
Depolarizing potential |
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Term
In olfaction, what is triggered by increasing levels of intracellular calcium?
What effect does this have? |
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Definition
The opening of calcium-activate Cl- channels.
Further depolarization of the cell. |
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Term
| In olfaction, what is the electric potential of the chloride ion? |
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Definition
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Term
| Why is Cl- current excitatory in olfactory receptor neurons? |
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Definition
| The concentration of Cl- inside cell is much higher than outside, so any potential negative to threshold causes Cl- efflux. This causes an inward current and depolarization. |
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Term
How does receptor potential spread from the cilia to the soma in the olfactory receptor neuron?
What will cause the axon to fire?
Are these axons myelinated or unmyelinated? |
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Definition
* Receptor potential spreads passively to soma
* If potential at soma exceeds action potential threshold, then the axon will fire
* Unmyelinated |
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