Term
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Definition
contains neurons involved in sensory processing; includes general (somatic) sensory afferent column and visceral sensory afferent column |
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Term
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Definition
structure separating sensory area from motor area |
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Term
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Definition
autonomic control, reflexes, motor processing, and sensory processing |
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Term
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Definition
area containing interneurons that process motor information and output neurons that send efferent information away from CNS; divided into visceral (autonomic preganglionic) efferent section next to the sulcus limitans and the LMNs more ventrally |
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Term
developmental stages of the spinal cord |
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Definition
marginal, mantle, and ependymal |
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Term
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Definition
white matter of spinal cord |
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Term
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Definition
gray matter of spinal cord |
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Term
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Definition
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Term
division of white matter in spinal cord |
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Definition
posterior, lateral, and anterior columns |
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Term
division of gray matter in spinal cord |
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Definition
posterior, intermediate, and anterior regions |
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Term
axial section at cervical level (characteristics) |
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Definition
has high ratio of gray:white matter; 8 nerves with only 7 vertebrae; nerves exit above vertebrae |
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Term
axial section at thoracic level (characteristics) |
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Definition
decrease in neural processing of info here; has small amounts of gray matter; reflects less complex innervations |
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Term
axial section at lumbar level (characteristics) |
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Definition
has more space for dorsal and ventral rootlets to expand; has relatively low amounts of white matter; has conus medullaris and cauda equina |
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Term
external cord features on anterior surface of cord |
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Definition
one deep fissure along midline that spans entire length; rootlets are somatic and visceral efferents |
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Term
external cord features on the posterior surface |
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Definition
has median sulcus that runs length of cord; has intermediate sulcus to separate column nuclei that runs from C1 to thoracic; rootlets contain somatic and visceral afferents |
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Term
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Definition
region of the spinal cord that has rootlets from higher vertebral levels via the cauda equina; also contains filum terminale and dural sac; level where lumbar puncture happens |
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Term
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Definition
ligament that anchors conus medullaris to the bottom of the vertebral column |
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Term
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Definition
specific distinctions of gray matter of the spinal cord that contain certain tracts/nuclei |
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Term
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Definition
called the substantia gelatinosa; forms synapses between C fibers; located dorsally |
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Term
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Definition
called nucleus proprious; more medial compared to gelatinosa; cells are proprioceptive |
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Term
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Definition
called the lower motor neurons; located near the outer edge of the ventral horn of gray matter; contains cell clusters of alpha motor neurons |
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Term
4 ascending cerebellar pathways |
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Definition
dorsal spinocerebellar tract, ventral spinocerebellar tract, rostral spinocerebellar tract, and cuneocerebellar tract |
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Term
2 somatosensory ascending tracts |
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Definition
dorsal columnar medial lemniscus tract and anterolateral tract |
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Term
dorsal column medial lemniscus tract |
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Definition
responsible for epicritic perception (discriminative touch, vibratory sense, and conscious muscle joint sense); initiates as axons ipsilateral to the receptive field of primary dorsal root ganglia sensory neurons; primary neuron terminates in ipsilateral brainstem and decussates at the caudal medulla |
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Term
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Definition
responsible for protopathic sensation (light/crude touch, pressure, pain, temp); contains axons of contralateral 2nd order neurons (Rexed 2); decussates at spinal level; while ascending rostrally axon enters tract ventromedially; info from legs carried in most anterior/lateral portion, while upper body info is ventral/medial |
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Term
dorsal spinocerebellar tract |
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Definition
tract whose axons of 2nd order neurons originate in the ipsilateral dorsal grey (Rexed 7); transmits proprioceptive information of trunk and lower limbs |
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Term
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Definition
proprioceptive axons are within cuneate fascicle (no clear delineation) |
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Term
ventral spinocerebellar tract |
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Definition
axons of this tract originate mostly in contralateral dorsal grey matter (Rexed 7 and 8); receives muscle joint information of trunk and upper and lower limbs (*note: axons may decussate and terminate in cerebellum) |
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Term
rostral spinocerebellar tract |
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Definition
a poorly delineated pathway; head/arm equivalent of VSCT |
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Term
descending pathways that are flexor biased |
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Definition
lateral corticospinal and rubrospinal tracts |
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Term
descending pathways that are extensor biased |
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Definition
medullary/pontine reticulospinal, tectospinal, and ventral corticospinal tracts |
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Term
lateral anterior portion of ventral horn contains: |
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Definition
loci of motor neurons for distal muscles |
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Term
medial anterior portion of ventral horn contains: |
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Definition
contains motor neurons for proximal muscles |
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Term
corticospinal tract trajectory |
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Definition
starts in primary motor cortex, then proceeds through the posterior limb of the internal capsule to the basis pedunculi of the midbrain, then to the basis pontis, then to the medullary pyramid; it then decussates at the cervicomedullary junction and ends up in the lateral intermediate zone and motor nuclei |
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Term
lateral corticospinal tract |
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Definition
tract with contralateral motor cortex origin; axons in this tract innervating upper body motor neurons are in the medial portion while the lower body motor neurons are more lateral |
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Term
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Definition
primary nerve fibers carrying protopathic sensory info enter dorsal horn 1-2 levels below secondary synapse and travel caudally; axons of secondary neurons decussate via ventral white commissure and THEN enter tract |
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Term
somatotopic organization of DCML |
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Definition
in this tract lower body input is medial while upper is lateral; gracile fascicle is responsible for legs and lower trunk, and cuneate fascicle is responsible for the upper trunk/arms/neck; dorsal intermediate septum separates tracts |
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Term
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Definition
primary neurons are pseudo-bipolar and their axons enter the dorsal horn and ascend ipsilateral dorsal column; first synapse and subsequent decussation is at the dorsal column nuclei; peripheral fibers include type A-alpha and A-beta fibers |
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Term
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Definition
if injury occurs it will present on the ipsilateral side because decussation occurs at medulla |
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Term
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Definition
injury to periphery of this pathway presents contralaterally because there is decussation at the spinal level |
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Term
unilateral lesion in ipsilateral lateral corticospinal tract |
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Definition
somatic motor control at and below lesion is absent (ipsilateral to lesion); contralateral motor function remains intact |
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Term
unilateral spinal lesion in ipsilateral DCML |
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Definition
ipsilateral to lesion, epicritic sensation at and below level is lost; contralateral epicritic sensation spared |
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Term
unilateral spinal lesion in ipsilateral ALS |
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Definition
protopathic sensation at/below and ipsilateral to lesion remains while contralateral is lost |
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Term
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Definition
in this lesion there is total loss of vibration/position sense, pain/temp, and motor function below level of lesion |
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Term
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Definition
in this lesion type vibration/position sense and motor function are lost on the side ipsilateral to the lesion; pain and temperature sense loss occurs on the contralateral side and above level of injury (1-2 levels) on ipsilateral side |
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Term
circulation of spinal cord (3 parts): |
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Definition
radicular arteries, ant. and post. spinal arteries, and vasocorona |
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Term
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Definition
branches off ant. artery and penetrates ant. spinal cord; goes to one side or the other and alternates side of penetration; supplies 2/3 of gray and white matter |
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Term
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Definition
fed by both ant. and post. radicular arteries; supply more external portions of SC |
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Term
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Definition
arteries whose purpose is to replenish the oxygenated blood supply to the SC |
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Term
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Definition
loss of blood supply; causes loss of vibration and position sense bilaterally |
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Term
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Definition
loss of blood supply; causes loss of pain/temperature sensation and motor function bilaterally |
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Term
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Definition
branch of ant. spinal artery supplies ventral funiculus and most of lat. funiculus of white matter and ventral horn/intermediate zone/deep dorsal horn of gray matter |
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Term
sulcal artery occlusion at L1 (example) |
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Definition
causes signs/symptoms in lower trunk/leg; ipsilateral loss of pain/temp and motor function; contralateral and epicritic sensation remains intact; lesion includes: ventral horn, ALS, LCST, and ipsilateral sympathetic preganglionic |
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Term
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Definition
feeds into ant. spinal artery as major source of blood supply for lumbar levels and below; ant. spinal artery not adequate source; important consideration for abdominal surgery since it can be easily nicked |
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Term
artery of Adamkiewicz occlusion |
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Definition
this occlusion is identical to anterior cord syndrome but from the waist down; bilateral motor loss and protopathic sensory loss |
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Term
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Definition
muscle spindle and Golgi tendon organ |
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Term
muscle receptor functions |
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Definition
provides critical info to CNS about muscle status; basically length and tension; also: play role in movements and reflexes |
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Term
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Definition
mechanoreceptors, resemble Ruffini endings and Pacinian corpuscles; do not contribute much to proprioception; important for detecting limits of movement |
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Term
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Definition
spinal motor neurons that innervate extrafusal muscle fibers |
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Term
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Definition
class of spinal motor neurons concerned w/ regulation of muscle spindle length; innervate intrafusal muscle fibers |
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Term
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Definition
rapidly adapting; provide info to CNS about rate of change and direction of movement; innervate nuclear bag and chain fibers |
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Term
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Definition
smaller, slowly adapting; provide info about static position of limbs; innervate mainly chain fibers |
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Term
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Definition
is a highly specialized sensory receptor; 3-4mm in length; fusiform in shape; located in the belly of skeletal muscle; stretch activates afferents but contraction does not! |
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Term
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Definition
can respond to efferents; modified striated muscle fibers; enclosed within spindle; 2 types are nuclear bag and nuclear chain fibers |
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Term
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Definition
large muscle mass that generates true force for moving limbs; parallel to MS |
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Term
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Definition
slender capsule located in tendon of extrafusal muscle; functionally in series with tendon of extrafusal muscle; tension evokes 1b afferent discharge; has incredible sensitivity to small changes in muscle tension; responds to both stretch and contraction |
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Term
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Definition
low activity is adequate for static conditions while activity is heightened for rapidly changing muscle length; activity of this system sensitizes muscle spindles |
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Term
descending pathways control of muscle |
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Definition
causes co-activation of alpha and gamma MNs; provides normal tonic drive of gamma MNs; important for normal spinal reflex; CNS lesions can affect tonic drive of gamma MNs and muscle tone (spastic paralysis) |
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Term
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Definition
stereotypic reaction evoked in response to stimulus; many somatic and autonomic functions mediated by cord are this in nature |
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Term
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Definition
reflex containing afferent and efferent components; ex: myotactic reflexes |
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Term
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Definition
reflex center consists of 1 or more interneurons; ex: flexor withdrawal, cross extensor |
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Term
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Definition
when the muscle spindle senses stretch, the 1a afferent fires and synapses on all LMNs (hundreds) of homonymous muscle in Rexed 9; relaxation of antagonist muscle is caused by reciprocal inhibition |
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Term
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Definition
stimulus causes quad muscles to stretch; 1a afferent phasic discharge occurs; reflex causes extension; reflex contraction of homonymous and synergist makes it monosynaptic |
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Term
relaxation of antagonist in patellar reflex |
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Definition
by reciprocal inhibition; considered a polysynaptic reflex |
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Term
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Definition
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Term
brachioradialis reflex tests: |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
response to stretch, mediated by 1b GTO afferent; causes relaxation of synergist and mononymous; effects readily observed in extensor muscles; effects are more widespread than MS afferents; is considered a tension-feedback system; has a high threshold so that it does not constantly fire; responsible for initial increased muscle tension during muscle fatigue |
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Term
withdrawal reflex and cross-extensor reflex |
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Definition
reflex mediated by small diameter afferents (A-delta); activates ipsilateral flexors and inhibits ipsilateral extensors; crosses over SC and inhibits contralateral flexors while activating contralateral extensors; polysynaptic; afferents convey info about painful/noxious stimuli; serves to protect/escape; very fast |
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Term
flexor withdrawal reflex (stepping on tack) |
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Definition
flexion occurs at the knee to avoid painful stimuli; mediated by multiple spinal levels; includes Lissauer's tract (central projecting processes of pain afferents); allows for response before expletive word is said (very quick) |
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Term
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Definition
decreased muscle tone leading to decreased resistance on muscle; limb is flaccid |
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Term
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Definition
increased tone leading to increased resistance; 2 types: spasticity and rigidity |
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Term
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Definition
clasp-knife type of increased resistance; also seen are hyperreflexia and clonus; low-threshold stretch reflex; typical of UMN lesion |
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Term
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Definition
sustained rhythmic contraction evoked by sudden maintained stretch; differs from fasciculation |
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Term
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Definition
typical of Parkinson's patients; cog-wheel type of increased resistance ("gives then locks"); not often associated with changes in stretch reflexes |
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Term
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Definition
immediate condition following transection; loss of all reflexes including sphincteric; flaccid paralysis below lesion; decreased sympathetic tone; concern about BP due to effect on vascular smooth muscle |
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Term
spinal shock (chronic outcome) |
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Definition
areflexia disappears and hyperreflexia occurs in flexor muscles; UMN signs; some sphincteric/erectile reflexes occur w/o voluntary control; transmitter receptor supersensitivity causes increased stretch reflexes; removal of descending inhibitory influences from supraspinal levels causes disinhibition of reflex arcs; collateral sprouting associated with it |
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Term
intrinsic spinal cord circuits following transection |
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Definition
sensory feedback triggers circuits for rhythmic motor activity; DOES NOT REQUIRE CEREBRAL CORTEX! |
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Term
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Definition
affects individual muscles in regards to weakness; pronounced atrophy; hypotonia observed; tendon reflexes depressed or lost; plantar reflex is flexion; fasciculation present |
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Term
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Definition
muscle weakness affects groups of muscles; atrophy is slight due to disuse because signal still goes to muscles; spastic hypertonicity; increased tendon reflexes; plantar reflex exhibits Babinski sign; fasciculation absent |
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Term
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Definition
dorsiflexion of big toe following stimulus on plantar surface; indicates CST (UMN) damage; normal in neonates |
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Term
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Definition
brisk muscle stretch reflexes, Babinski sign, weakness, increased muscle tone, muscle stiffness (spasticity), hyperreflexia, clonus (due to hyperactive MSR) |
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Term
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Definition
decreased muscle stretch reflexes, hyporeflexia, fasciculations, atrophy |
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Term
structures susceptible to peripheral neuropathy |
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Definition
cell bodies, axons, Schwann cells, and vasculature |
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Term
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Definition
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Term
motor neuron (CNS) cell body location |
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Definition
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Term
autonomic neuron (CNS/PNS) cell body location |
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Definition
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Term
sensory neuron (PNS) cell body location |
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Definition
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Term
significance of distance between motor and sensory cell bodies |
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Definition
ensures that peripheral neuropathy is restricted to either motor or sensory deficit |
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Term
large diameter myelinated motor axons |
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Definition
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Term
large diameter myelinated sensory axons |
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Definition
to muscle spindle, transmit light touch/vibration/position/spinocerebellar input |
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Term
Roman numbering used with: |
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Definition
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Term
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Definition
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Term
small diameter myelinated motor axons |
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Definition
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Term
small diameter myelinated sensory axons |
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Definition
STRONG, transmit sharp/localized pain, cool temperature |
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Term
small diameter autonomic myelinated axons |
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Definition
preganglionic axons making up white ramus |
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Term
small diameter unmyelinated sensory axons |
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Definition
transmit aching/burning and less localized pain; also: warm temperature |
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Term
small diameter autonomic axons |
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Definition
make up postganglionic fibers or gray ramus |
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Term
4 physical forces that produce compression/traction |
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Definition
ischemia due to compression of vasa vasorum, myelin sheath compression, axon disruption (axonotmesis), and axon/associated supportive tissue disruption (neurotmesis) |
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Term
examples of compression in anatomically restricted areas |
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Definition
1) spinal nerve compression by herniated disc 2) ulnar nerve entrapment in cubital tunnel 3) median nerve entrapment in carpal tunnel |
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Term
examples of penetrating nerve injury |
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Definition
GSWs and stabbings, mostly cause axon disruptions |
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Term
endogenous nerve metabolism disturbance |
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Definition
diabetes or renal failure |
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Term
exogenous nerve metabolism disturbance |
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Definition
alcohol or chemotherapeutic agents |
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Term
genetic nerve metabolism disruptions |
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Definition
Charcot Marie Tooth disease |
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Term
idiopathic nerve metabolism disturbance |
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Definition
amytrophic lateral sclerosis |
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Term
examples of inflammatory attacks on Schwann cells/axon/cell body |
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Definition
response after infection/vaccination (Guillain Barre syndrome), paraneoplastic response associated with certain cancers |
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Term
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Definition
polio and West Nile viruses |
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Term
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Definition
herpes zoster (shingles) and HIV |
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Term
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Definition
agent causing leprosy (M. leprae) |
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Term
short term compression results in: |
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Definition
axon metabolism disturbed and AP propagation blocked by local ischemia; onset within minutes; recovery within minutes; large myelinated axons are most susceptible; sensory axons more affected than motor neurons |
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Term
prolonged local compression results in: |
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Definition
Schwann cells are damaged in area of compression; conduction block (neurapraxia) occurs; onset over several hours; recovery over weeks to a few months; axons remain intact distal to lesion and still respond to stimuli; minimal atrophy occurs distal to lesion; axonal transport preserved |
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Term
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Definition
occurs by local dismantling and rebuilding of myelin; Schwann cells divide; newly formed internodes are shorter than normal (intercalated segments); typically fully clears |
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Term
physical disruption of axons results in: |
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Definition
Wallerian degeneration; immediate conduction changes; axonal changes within 5 days; atrophy and denervation; lack of trophic factors; recovery by regeneration of injured axons or sprouting (reinnervation); time course is months to 2 years; degree of recovery variable; aberrant reinnervation can occur |
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Term
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Definition
neuronal changes in which the cell bodies swell, Nissl substance breaks up, and RNA synthesis increases |
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Term
axonal changes in physical disruption include: |
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Definition
myelin degeneration; axonal atrophy (axonotmesis); response to electrical stimuli absent distal to lesion; loss of transport of substances beyond lesion |
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Term
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Definition
regenerating axons may end up with different destinations than original axons; can cause neuropathy |
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Term
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Definition
abrupt drop in compound motor action potential amplitude along nerve as seen on EMG; is the hallmark of focal demyelinating lesion; response amplitude distal to lesion is normal because myelin and axon are intact; diffuse demyelination occurs |
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Term
nerve conduction study reveals axonal damage when: |
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Definition
low (or no) response at all stimulated sites along the nerve |
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Term
motor unit potential parameters measured during needle EMG |
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Definition
duration, amplitude, configuration stability, firing rate |
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Term
patterns of clinical abnormality in neuropathy |
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Definition
radiculopathy, plexopathy, mononeuropathy, polyneuropathy, and neuronopathy |
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Term
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Definition
usually occurs in foramina; involves dorsal and ventral roots as well as spinal nerve; nerve becomes compressed in spinal foramen by herniated nucleus pulposus or osteophyte ("hard disc"); symptoms correspond to motor, sensory, and deep ache site territories of compressed nerve |
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Term
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Definition
pattern of nerve involvement in limb greater than single nerve or root lesion; ex: Erb's palsy following delivery, lumbar plexopathy in diabetic; causes: trauma, inflammation following vaccination/systemic infections, compression by cervical rib/retroperitoneal hematoma, hereditary condition, or idiopathic |
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Term
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Definition
abnormality localized to single peripheral nerve or segment; caused by constriction or superficial vulnerability; examples: carpal tunnel, cubital tunnel, Saturday night palsy, foot drop, Bell's palsy, or meralgia paresthetica |
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Term
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Definition
has bilateral and symmetric pattern; deficits do not correspond to single nerve/root; distal segments involved (length dependent); sensation is usually more abnormal than motor function; abnormalities move more proximal if condition worsens; causes: metabolic disturbance (diabetes/renal failure), toxins (alcohol or chemotherapy), autoimmune (GBS), or hereditary (CMT) |
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Term
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Definition
sensory perception in cerebral cortex dependent on it working properly; allows voluntary movements by mediating motor pathways; essential for consciousness and subconscious control of cardiovascular and respiratory systems |
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Term
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Definition
central core of midbrain and pons |
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Term
parts of brainstem ventral to tegmentum |
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Definition
basis pedunculi, basis pontis, pyramids, substantia nigra (really mesencephalic), and pontine nuclei |
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Term
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Definition
consists of tegmentum and basis pedunculi; entire midbrain except tectum |
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Term
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Definition
consists of crus cerebri and substantia nigra |
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Term
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Definition
all white matter of the brainstem; contains CST and CBT descending tracts |
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Term
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Definition
superior colliculus, PAG and cerebral aqueduct, oculomotor nuclei and 3rd exit, EW nucleus, red nucleus; thalamic nuclei and optic tracts around it |
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Term
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Definition
inferior colliculus, decussation of superior cerebellar peduncles, trochlear nucleus |
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Term
upper midbrain ABOVE mammillary bodies features: |
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Definition
pulvinar, med. geniculate nuclei, lat. geniculate nuclei (thalamic); optic tract passing to LGB, pineal gland |
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Term
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Definition
chief sensory V nucleus, motor V nucleus, mesencephalic V nucleus, superior cerebellar peduncle |
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Term
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Definition
facial colliculus, abducens and facial motor nuclei, sup/lat vestibular nuclei, spinal nucleus V, inferior cerebellar peduncle, solitary tract/nucleus |
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Term
medulla near PMJ features: |
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Definition
cochlear nucleus/8th root |
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Term
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Definition
12th nucleus/tract, DMNX, vestibular nuclei, nucleus ambiguus (also seen at PMJ), ICP, inferior olive |
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Term
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Definition
dorsal column nuclei (cuneate and gracilis), spinal central canal, decussation of pyramids, continuation of spinal n. and tract |
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Term
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Definition
has motor and parasympathetic components; LMNs exit ventromedially; Edinger Westphal nucleus contains preganglionic parasympathetic neurons exiting w/ corresponding nerve; nerve projects through midbrain structures |
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Term
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Definition
motor nucleus only; LMNs exit dorsally; control eye movements |
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Term
3 trigeminal sensory nuclei |
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Definition
chief sensory responsible for epicritic; mesencephalic responsible for proprioception; spinal descending responsible for P/T |
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Term
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Definition
LMNs to muscles of mastication; located medially to sensory portion |
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Term
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Definition
motor fibers arise at facial colliculus; eye movements and lateral gaze; LMNs exit medially; innervates lat. rectus |
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Term
facial nucleus components: |
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Definition
motor, parasympathetic, and sensory (special and general somatic) |
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Term
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Definition
sends LMN fibers dorsomedially to facial colliculus; fibers then travel ventrally and laterally to nucleus; NOTE: vestibular/spinal nucleus V are lateral to exiting fibers!!! |
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Term
facial parasympathetic nucleus |
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Definition
aka superior salivatory nucleus; sends preganglionic parasympathetic fibers to exiting LMNs |
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Term
facial nerve special sense portion |
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Definition
taste fibers project into brainstem towards nucleus of solitary tract |
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Term
facial nerve general somatic sense |
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Definition
small projection to spinal trigeminal nucleus V |
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Term
vestibulocochlear nucleus |
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Definition
for special sensory use only, hearing |
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Term
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Definition
located at upper medulla near PMJ; cochlear nerve projects to it; sensory only |
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Term
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Definition
located in lower pons and upper medulla; several separate components; afferent vestibular fibers enter it; sensory only |
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Term
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Definition
has sensory, parasympathetic, and motor components |
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Term
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Definition
nucleus ambiguus sends LMNs to nucleus and nerve |
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Term
vagus parasympathetic nucleus |
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Definition
located in DMNX; preganglionic fibers arise from it; for H/N, lung, GI |
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Term
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Definition
both special and general somatic portions; taste fibers from inf. vagal ganglion to solitary tract/nucleus (rostral part); sup. vagal ganglion fibers project to spinal tract V, gets protopathic info from small H/N region; viscerosensory info to caudal NST (cardiorespiratory!!!) |
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Term
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Definition
motor only; LMNs exit medially then lat to medullary pyramids; tongue muscles ipsilateral innervated; exit restricted to upper medulla but this nucleus is elongated along large part of medulla |
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