Term
Synthesis of NO
(diagram) |
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Definition
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Term
NO ACTIONS AND TARGET
NO production has been implicated in:
Physiology
(list of 8) |
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Definition
neurotransmission
memory formation
vasodialation
regulation of BP
regulation of cardiac contractility
platelet aggregation
penile erection
host defense |
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Term
NO ACTIONS AND TARGET
NO production has been implicated in:
Pathology
(4) |
|
Definition
septic shock
autoimmune diseases
graft vs host
liver cirrhosis |
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Term
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Definition
hypotension
vascular leakage |
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Term
NO
autoimmune diseases
(5) |
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Definition
RA (rheumatiod arthritis)
ulcerative colitis
DM (diabetes)
MS
Asthma |
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Term
NO INTERACTIONS
TARGET
heme protiens 3
fe-s proteins 2 |
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Definition
soluble guanylyl cyclase
cytochromes P450
Hemeglobin
aconitase
mitochondrial complet 1,2 |
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Term
action:
soluble guanylyl cyclase |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| mitochondrial complexes 1,2 |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
strand cleavage
deanimation |
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Term
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Definition
Reaction with transition metal centers
s- nitrosation
peroxynitrite-mediated reactions
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Term
Reaction with transition metal centers
how?
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Definition
major physio target of nNOS and eNOS is soluble guanlyl cyclase which
makes cGMP from GTP (increases in cGMP levels mediate many of the physiological actions of NO) |
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Term
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Definition
post traslational modification at the thiol side chain of cysteine residues
occurs through a complex chem mechanism w/o addtl enzymes
require high concentrations of no |
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Term
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Definition
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Term
| who is typing on the john? |
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Definition
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Term
endothelial NOS (eNOS; NOSIII)
how do these isoforms effect:
tissue distribution
subcellular distribution
amount of NO synthesized
Regulaton
Action of NO producted
NO signaling of vascular smooth muscle
(heavy card, sry didnt wanna type it all) |
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Definition
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Term
| How does NO cause vasodilation? |
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Definition
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Term
Neuronal NOS
tissue distribution |
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Definition
| CNS, PNS, and skeletal muscle |
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Term
Neuronal NOS
subcellular distribution
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Definition
nNOS is soluble, tho its localized to the
membrane via protein/protein interactions |
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Term
Neuronal NOS
amount of NO synthesized
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Definition
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Term
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Definition
| activated by an influx of calcium and subsequent CaM binding |
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Term
Neuronal NOS
action of NO producted
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Definition
CNS- neurotranmitter
PNS- relaxes intestinal smooth muscles (sphincters)
SM- mediated contractile force |
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Term
Neuronal NOS
signaling in the CNS
and
PNS
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Definition
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Term
Neuronal NOS
NO signaling in the skeletal muscle
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Definition
relaxes through the cGMP pathway
(see previous card) |
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Term
Inducible NOS (iNOS; NOSII)
tissue distribution |
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Definition
macrophage
neutrophil
liver |
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Term
Inducible NOS
subcell distribute |
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Definition
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Term
Inducible NOS
amount of NO synthsized |
|
Definition
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Term
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Definition
| transcriptional via cytokine or endotoxin induction. CaM is bound to iNOS under basal physio condition. therefore enzyme is always in the activated state |
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Term
Inducible NOS
action of NO producted |
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Definition
| cytotoxicity via peronitirite formation, DNA cleavage and deanimation, nitrosation of proteins, and inhibition of heme proteins |
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Term
Cytotoxic Roles of NO
1._____and 5 ex
2._____and 2 ex
3.____________
4._____________ |
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Definition
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Term
NO in septic shock
(important in real life) |
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Definition
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Term
Mechanism of Action of Sildenafil
(viagra) |
|
Definition
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