Term
| What is the mechanism of giving Levodopa with carbidopoa |
|
Definition
Levodopa= works as the L-dopa intermediate and is made into dopamine presynaptic neuron. Can cross the BBB.
Carbidopa= Makes it so more Levodopa gets into the blood and less is metabolised.
|
|
|
Term
| What is the mechanism of Pramipexole? |
|
Definition
Dopamine receptor agonist
given orally |
|
|
Term
| What is the mechanism of ropinirole? |
|
Definition
dopamine receptor agonist
given orally |
|
|
Term
| What is the mechanism of Rotigotine? |
|
Definition
dopamine receptor agonist
transdermal patch. |
|
|
Term
| What are adverse effects of dopamine agonists? |
|
Definition
| urge to gamble and fuck, also nausea, vomiting , halleucinations, HTN, |
|
|
Term
| What is the mechanism of Rasagiline and Selegiline? |
|
Definition
| MAO-B inhibitors. MAO-B breaks down Dopamine. Reduces ROS and may slow progression. |
|
|
Term
| What happens if u take too much tyramine with an MAO inhibitor. |
|
Definition
| "cheese reaction" NE accumulates in synaptic vessicles. |
|
|
Term
| What are some side effects of Selegiline? |
|
Definition
| gets converted in methamphetamine and amphetamine so you want to give early in the day, morning and noon. |
|
|
Term
| You cannot give _____ with MAO inhibitors or you will get a serotonin syndrome. |
|
Definition
|
|
Term
What is the mechanism of Entacapone and what is it used for?
|
|
Definition
Inhibits COMT (Catechol-O-Methyltransferase)
Increases prenetrability of BBB which extends the half life of levodopa. Used to treat the wearing off of levodopa. Only used with Levodopa. |
|
|
Term
What is Dyskinesia?
When does it occur?
how is it managed? |
|
Definition
weakened motor control
wearing off levodopa
add a dopamine agonist reduce levodopa ammounts. |
|
|
Term
| What is the mechanism of Amantadine? |
|
Definition
| reduces levodopa induced dyskinesia. antiviral agent used to treat influenza also |
|
|
Term
| What is the mechanism of Benzotropine? |
|
Definition
effective for parkinson patients bothered by tremors. Given to people under 50.
Causes constipation and dry mouth. |
|
|
Term
What is the mechanism of Apomorphine?
|
|
Definition
| dopamine receptor agonist that is injected in emergency situations. |
|
|
Term
| What drugs can induce parkinsons? |
|
Definition
Dopamine receptor blocking drugs
Typical neuroleptic antipsychotic drugs
Antidopaminergic antiemetics |
|
|
Term
| What is the most common initial treatment for parkinsons? |
|
Definition
|
|
Term
| Who is the "second victim" in medical errors? |
|
Definition
| the doctor or nurse who made the error. |
|
|
Term
| Describe the "swiss cheese" model for accident causation. |
|
Definition
| need multiple layers of defences, safeguards, and barriers |
|
|
Term
| What are predictive safety methods? |
|
Definition
| data mining to look at real time data and assess risks. |
|
|
