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OB/Gyn
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155
Medical
Graduate
04/30/2015

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Term
Define

Embryo

Fetus

Infant
Definition
Embryo: fertilization - 8 weeks

Fetus 8 weeks to birth

Infant: birth to 1 year
Term
Developmental age (DA)
Definition
# of days since fertilization
Term
Gestational age (GA)
Definition
# of days/weeks after LMP (2 weeks longer than DA)
Term
Nagele's rule
Definition
LMP - 3 month + 7 days
Term
1st Trimester
Definition
fertilization until 12 (DA) or 14 (GA) weeks
Term
2nd Trimester
Definition
12(DA)/14(GA) to 24(DA)/26(GA)
Term
3rd Trimester
Definition
24(DA)/26(GA) weeks until delivery
Term
Pre-viable
Definition
<24 weeks
Term
Preterm
Definition
25-37 weeks
Term
Term
Definition
38-42 weeks
Term
Post-term
Definition
>42 weeks
Term
Gravidity
Definition
# of times pregnant
Term
Parity(abcd)
Definition
a: Full Term
b: Pre-term
c: Abortions
d: Living children
Term
Goodell sign
Definition
Softening of cervix, 4 weeks, first sign
Term
Ladin sign
Definition
Softening of the midline of uterus, 6 weeks
Term
Chadwick sign
Definition
Blue discoloration of vagina and cervix, 6-8 weeks
Term
Telangiectasia
Definition
1st Trimester
Term
Chloasma
Definition
hyperpigmentation of face, 2nd trimester
Term
Linea nigra
Definition
line of hyperpigmentation from xiphoid to pubic symphysis, 2nd trimester
Term
Diagnostic test for pregnancy
Definition
beta-HCG
-increases since fertilization, peaks at weak 10, does down during 2nd trimester, increases in third trimester (20-30,000 IU)
Term
5 weeks of pregnancy
findings on US and bHCG
Definition
gestational sac on ultrasound
b-HCG > 1000IU
Term
Cardiac changes in Pregnancy
Definition
Increase in CO, HR
Lower BP (lowest at 24-28 weeks)
Term
GI changes in Pregnancy
Definition
Morning sickness (caused by increased estrogen, progestrone, HCG)
Reflux: decrease LES tone
Constipation: decreased large intestinal motility
Term
Renal changes in pregnancy
Definition
Increased kidney and ureter size
Increased likelihood of pyelonephritis due to ureter compression by uterus
Increase GFR (due to 50% increase in plasma volume)
-decrease bun/cr
Term
Hematological changes in pregnancy
Definition
Anemia (increased plasma volume)
Hypercoagulable state
-normal coags
-increas fibrinogen
-Venous stasis
Term
Prenatal care: 1st Trimester
Definition
Routine visit every 4-6 weeks
11-14 weeks US for gestational age and nuchal lucency
pap smear, chlymidia/gonorrhea
non-invasive screening
Term
Prenatal care: 2nd trimester
Definition
Triple or Quad screen
-maternal serum AFP (MSAFP) : increase -> dating error, neural tube defect
-b-HCG
-estriol
-inhibin A

Auscultation of fetal heart rate
16-20 weeks : quickening
18-20 weeks: routine US
Term
Prenatal care: 3rd trimester
Definition
Routine visits (2-3 weeks) until 36th week, weekly visits after
Term
Braxton-Hicks Contractions
Definition
sporadic contractions in 3rd trimester, no cervical dilation

if regular, check cervix for preterm labor
Term
Ectopic pregnancy risk factors
Definition
PID
IUD
previous ectopic pregnancies
Term
Ectopic pregnancy presentation
Definition
unilateral lower abdominal pain
pelvic pain
vaginal bleeding
if ruptured, hypotensize with peritoneal irritation
Term
Ectopic pregnancy diagnostic tests
Definition
b-HCG: positive
Ultrasound
Laparoscopy
Term
Ectopic treatment
Definition
Unstable: IV fluids, OR
Stable:
CBC, type & screen, transaminases, b-HCG
tx with MTX, successful is b-HCG decreases by 15% in 7 days.

Do not use MTX if:
-immunodeficiency
-poor compliance
-ectopic > 3.5cm
-fetal heart beat present

RhoGam for Rh negative patients
Term
Complete abortion
Findings
Tx
Definition
No product of conception found
Routine follow-up
Term
Incomplete abortion
Findings
Tx
Definition
Some product of conception found
D&C/Medical
Term
Inevitable abortion
Findings
Tx
Definition
Products of conception intact, intrauterine bleeding, dilation of cervix
D&C/medical
Term
Threatened abortion
Findings
Tx
Definition
products of conception intact, intrauterine bleeding, no dilation of cervix
Bed rest/pelvic rest
Term
Missed abortion
findings
Tx
Definition
Death of fetus, all product of conception present
D&C/medical
Term
Septic abortion
findings
tx
Definition
Infection
D&C + abx (levoquin or flagyl)
Term
Multiple Gestation
Presentaiton
Definition
Exponential utero growth
Rapid maternal weight gain
elevated b-HCG and MSAFB
Term
Multiple Gestation
Complications
Definition
Spontaneous abortion
Premature Labor
Placenta Previa
Anemia
Term
Pre-term labor risk factors
Definition
Premature rupture of membranes
Multiple gestation
previous history of pre-term labor
Placental abruption

Maternal factors
-Uterine anomaly
-infections
-pre-eclampsia
Term
Pre-term labor presentation
Definition
contractions
dilation of cervix
between 20-37 weeks
Term
Situations to NOT use tocolytics in pre-term labor
Definition
pre/eclampsia
maternal cardiac dz
maternal cervical dilation
maternal hemorrhage
Fetal death
chorioamnionitis
Term
situations to USE tocolytics
Definition
24-33 GA
600-2500grams
Term
utility of betamethasone in pre-term
Definition
mature fetus lungs
decrease RDS
Peaks at 48hrs, lasts 7 days.
Term
Tocolytics

Examples
Definition
Decrease uterine contractions, and slow the progression of cervical dilation

Magnesium sulfate
-most common
-decrease tone and contractions
-side effects: flushing, headaches, diplopia, fatigue

Calcium channel blockers

Mag toxicity can lead to respiratory depression and cardiac arrest
Term
Pre-mature rupture of membranes
Diagnosis
Definition
speculum exam
-fluid in posterior fornix
-fluid turns nitrazine paper blue
-fluid has ferning pattern
Term
Define prolonged labor
Definition
-labor starts 24 hours before delivery
Term
Complications of premature rupture
Definition
-preterm labor
-cord prolapse
-placental abruption
-chorioamnionitis
Term
Premature rupture
Treatment
Definition
If chorioamionitis: delivery now

betamethasone
ampicillin
azithromycin
Term
Third trimester bleeding
2 types
Definition
Placental previa
Placental invasion
Term
Placental previa
definition
Definition
abnormal implantation of placenta over the internal cervical os
Term
Placental previa
risk factors
Definition
previous c-sections
previous uterine surgery
multiple gestation
previous placental previa
Term
placenta previa
presentation
dx
Definition
painLESS vaginal bleeding

Dx
Transabdominal ultrasound
Term
Types of placenta previa
Definition
complete: complete covering of internal cervical os
partial
marginal: adjacent to internal cervical os
vasa previa: fetal vessel over internal cervical os
low lying: implantation in lower segments of uterus
Term
placenta previa
tx
Definition
strict pelvic rest
Term
placenta accreta
Definition
abnormal adherence of placenta to different areas of uterus

hemorrhage
tx: hysterectomy
Term
placental abruption
definition
Definition
premature separation of placenta from uterus

large separation leads ot hemorrhage, uterine tetany, DIC, premature delivery
Term
placenta abruptio
etiology
Definition
maternal hypertension
history of abruption
maternal cocaine use
maternal trauma
maternal smoking
Term
placenta abruptio
presentaiton
Definition
3rd trimester PAINFUL bleeding
contractions
possible fetal distress
Term
placental abruptio
diagnosis
Definition
transabdominal ultrasound
Term
Types of placental abruption
Definition
concealed:
-blood in uterine cavity
-placenta more likely to be completely detached

-Serious complication
-DIC
-uterine tetany
-fetal hypoxia
-fetal death
-sheehan

external
-blood drains through cervix
-placenta partially detached
-smaller with minimal complication
Term
placental abruption
Treatment
Definition
C-section if
-uncontrollable maternal hemorrhage
-rapidly expanding concealed hemorrhage
-fetal distress
-rapid placental separation

vaginal delivery if
-placental separation is limited
-fetal heart tracing is assuring
-separation is extensive and fetus is dead
Term
Uterine rupture
definition
Definition
life-threatening to both mother and fetus and usually during labor
Term
uterine rupture
risk factors
Definition
classical c-sections
trauma
uterine myomectomy
uterine overdistention
-polyhydramnios
-multiple gestations
-placenta percreta
Term
uterine rupture presentation
Definition
suddent onset extreme abdominal pain
abnormal bump in abdomen
no uterine contractions
regression of fetus
Term
uterine rupture treatment
Definition
immediate laparotomy
Term
Hemolytic disease of newborne
Definition
Rh incompatibility
-fetal anemia
-extramedullary erythopoeisis
-increase bilirubin and heme
-high fetal cardiac output
Term
Rh
initial prenatal visit
Definition
Rh antibody screening test
Term
When is RhoGam given
Definition
-Amniocentesis
-abortion
-vaginal bleeding
-placental abruption
-delivery
Term
Prenatal antibody screening
Definition
unsensitived patient at 28 weeks need to receive RhoGAM
Term
Gestational hypertension
Definition
hypertension that starts after 20 weeks gestation
-no proteinuria, no edema
Term
Why are ACE and ARB contraindicated
Definition
fetal malformations
Term
Preeclampsia
Risk Factors
Definition
chronic hypertension
renal disease
Term
Eclampsia
Definition
seizure in patient with a history of pre-eclampsia
Term
Eclampsia
Tx
Definition
If pre-term
Magnesium sulfate for seizure
hydralazine for HTN
bethamethasone for Lung
Delivery the babby

If term, deliver baby
Term
HELLP syndrome
Definition
Hemolysis, Elevated liver enzymes, low platelets
Term
Pregestational Diabetes
definition
Definition
Pt with diabetes prior to pregnancy
Term
pregestational diabetes
complications
Definition
Maternal
-4x preeclampsia
-2x abortion
-infection
-postpartum hemorrhage

Fetal
-heart and neural tube defects
-macrosomia
-preterm labor
Term
pregestational diabetes
evaluation
Definition
EKG
24 hours urine cr and protein
HbA1C
Term
Gestational diabetes
complications
Definition
preterm birth
fetal macrosomia
birth injuries
neonatal hypoglycemia
Term
Gestational diabetes
Dx
Definition
glucose load 1st
glucose tolerance 2nd
Term
Gestational diabetes
Tx
Definition
NPH before bed
aspart before meal
Term
Intrauterine growth restriction
Definition
weight bottom 10%
Term
types of IGUR
Definition
symmetric before 20wks
asymmetric brain weight not increased after 20 weeks, abdomen < head
Term
IGUR etiologies
Definition
chromosomal abnormality
neural tube defects
infections
multiple gestations
maternal HTN
Term
Nonstress Test
Definite
Definition
Check for fetal well-being in utero
Measures fetal movement and HR
Term
Reactive NST
define
Definition
2 fetal movements
acceleration of fetal HR > 15 bpm lasting 15-20 seconds
Term
Biophysical profile
define
Definition
NST
fetal chest expansion (NL >1 per 30 minute)
fetal movement (>3 per 30 min)
fetal muscle tone
amniotic fluid index
each category is 2 points for max of 10
Term
Fetal Heart Rate
Definition
Normal 110-160
Brady <110
Tachy >160
Term
Accelerations
Definition
>15 increase in HR for longer 15s (NL twice in 20 minutes)
Term
Types of Decelerations
Definition
Early decelerations
Variable decelerations
Late decelerations
Term
Early decelerations
define
Definition
decrease in heart rate that occurs with contractions
-head compression
Term
Variable deceleration
define
Definition
decrease in HR with no relations to contractions
-umbilical cord compression
Term
Late decelerations
Definition
decrease in HR after contraction has started no return to baseline until contraction ends
-fetal hypoxia
Term
Lightening
Definition
fetal descent into pelvic brim (before labor)
Term
Braxton-Hicks contractions
Definition
benign contractions with no cervical dilations
Term
Bloody show
Definition
blood-tinged mucus from vagina with cervical effacement (before labor)
Term
Stages of labor
Definition
Stage 1:
-onset to full cervical dilation (prim 6-18hr, multi 2-10hr)

Latent phase
-onset to 4cm dilation (prim 6-7hr, multi 4-5)

Active phase
-4cm to full dilation (prim 1cm/hr, mult 1.2cm/hr)

Stage 2
-full dilation to delivery (prim 30-3hr, mul 5-30min)

Stage 3
-delivery neonate to delivery of placenta (30min)
Term
Stage 1 monitoring
Definition
Maternal BP/pulse
Fetal HR & contractions
Examine cervix for dilation, effacement
Station
Term
Stage 2
Definition
Engagement
-occiput enters pelvis
Descent
-uterine contraction & maternal pushing
Felxion
-fetal head fexion
Internal rotation
-head rotates at ischial spine
Extension
-head orientated forward and upward
External rotation
-give room for shoulder to extend
Delivery of anterior shoulder
Delivery of posterior shoulder
Term
stage 3
Definition
Signs of placental separation
-fresh blood in vagina
-umbilical cord lengthening
-uterine fundus rising
-uterus becoming firm
Term
Medications for inducing labor
Definition
Prostaglandin E2 - cervical ripening

Oxytocin -
-exaggerate uterine contractions

Amniotomy
-puncture of amniotic sac using amnio hook
Term
Prolonged latent stage
definition
Definition
latent phase last longer than 20 hours
Term
prolonged latent stage
etiology
Definition
sedation
unfavorable cervix
uterine dysfunction w weak or irreg contractions
Term
Prolong latent stage
tx
Definition
rest and hydration
resolve 6-12 hours
Term
Protracted cervical dilation
Definition
active phase of stage 1 labor
less than 1.2cm/hour in primi and 1.5/hr in multi
Term
protracted cervical dilation
etio
Definition
3P
Power: strength and frequency of uterine contractions
Passenger: size and position of fetus
Passage: cephalopelvic disproportion
Term
protracted cervical dilation
tx
Definition
c-section, oxyytocin
Term
Arrest disorders
Definition
Cervical dilations: No dilation for 2 hours
Fetal descent: no fetal descent for 1 hour
Term
Arrest disorders
Etio
Definition
Cephalopelvic disproportion
-50% of all arrest
Malpresentation
-fetus > 36 weeks not presenting with head downward
Excessive sedation/anesthesia
Term
Malpresentation
Definition
lower half of fetus is presenting part
can be felt during physical exam
-leopold maneuver
-vaginal exam

Dx with ultrasound
Term
Types of Breech
Definition
Frank breech- fetus hips are flex with extended knees
Complete breech- hips and knees are flex
Footling breech- feet first
Term
Tx for mispresentation
Definition
wait until 36 weeks
maneuver into position after 36 weeks
Term
Shoulder dystocia
definition/etio/tx
Definition
shoulder stuck in pubic symphisis after head has been delivered

macrosomia
late term delivery

tx
mcroberts maneuver
rubin maneuver
woods maneuver
deliberate fracture of clavicle
Term
Post-partum hemorrhage
definition
etio
Definition
>500cc bleeding after delivery

uterine atony (80%)
laceration
retained parts
coagulapathy
Term
Risk factors for atony
Definition
anesthesia
prolonged labor
uterine over distention
laceration
retained placenta
coagulopathy
Term
Post-partum hemorrhage
tx
Definition
bimanual examination
-make sure not rupture or retained placenta

bimanual compression and massage
oxytocin
Term
PMS/PMDD
symptoms
Definition
Headaches
Breast tenderness
pelvic pain/bloating
irratibility
Term
PMS/PMDD
Tx
Definition
decrease caffeine, alcohol, cigarettes, and chocolat.

SSRI
Term
Menopause
definition
Definition
permanent loss of estrogen (age 48-52)
Increase LH and FSH.
Term
Menopause symptoms
Definition
Menstrual irregularity
Sweats and hotflashes
Mood changes
Dyspareunia
Term
Menopause
physical exam
Definition
atrophic vaginitis
decrease breast size
vaginal cervical atrophy
Term
Menopause
Diagnosis
Definition
increase FSH
Term
Menopause
Tx
Definition
hormone replacement therapy for symptom relief and prevent osteoporosis
Term
Abnormal uterine bleeding
Dx
Definition
CBC
PT/PTT
pelvic ultrasound
Term
Menorrhagia
Definition
heavy and prolonged menstrual bleeding

endometriosis
uterine fibroids
IUD
Term
hypomentorrhea
Definition
light menstrual flow/spotting

obstruction(cervical stenosis)
ocp
Term
metromenorrhagia
Definition
intermenstrual bleeding
-endometrial polyps
-cancer
-exogenous estrogen
Term
menometrorrhagia
Definition
irregular bleeding
-endometrial polyps
-cancer
-estrogen
Term
oligomenorrhea
Definition
menstrual cycle >35 days

-pregnancy
-menopause
-weightloss
-estrogen secreting tumor
Term
postcoital bleeding
Definition
-cervical cancer
-cervical polyps
-atrophic vaginitis
Term
Dysfunctional Uterine Bleeding
Define
Diagnosis
Definition
unexplained abnormal bleeding.

Systemic reasons for anovulations (hypothyroid, hyperprolactin)

Endometrial biospy for pt > 35.
Term
Dysfunctional uterine bleeding

Tx
Definition
OCP

Acute hemorrhage
-D&C to stop bleeding.
Term
Labial fusion
Definition
excess androgenes

etiology
-21-B hydroxylase deficiency
-excess androgen

Tx:
Surgery
Term
Lichen sclerosus
Definition
white thin skin from labia to perianal

tx: topical steroids

increased risk of cancer
Term
squamous cell hyperplasia
Definition
associated chronic vulvar pruritus

raised white lesion (hyperkeratosis)

sitz bath, lubricants
Term
lichen planus
Definition
30-60s
violet flat papules

tx: topical steroids
Term
Bartholin gland cyst
Definition
inflammation of bartholin glands (lateral vulva)

pain, tenderness, dyspareunia

Tx:
I&D, culture for gonorrhea and chlamydia
Term
Vaginitis
Risk factors
Definition
Abx use
diabetes
overgrowth of normal flora
Term
Bacterial vaginitis
Definition
Gardnella
gray white discharge
fish odor
clue cells
metronidazole/clindamycin
Term
candidiasis
Definition
candida
white cheesy discharge
KOH pseudohyphae
miconazole/clotrimazole
Term
Trichomonas
Definition
trichomonas
green frothy discharge
motile flagellates
metronidazole for both partners
Term
Paget disease
Definition
vulvar soreness and pruritis
red lesion with a superficial white coating
biopsy for diagnosis

tx: vulvectomy.
Term
Squamous cell carcinoma
presentation
Definition
pruritis
vaginal discharge
postmenopausal bleed

dx biopsy
Term
SCC staging
Definition
0 carcinoma in situ
1 limited to vaginal wall <2cm
2 limited to vulva or perineum >2cm
3 tumor spread to urethra, anus, lymphnodes
4 bladder, rectum, bilateral lymphnodes
4a distant mets
Term
Adenomyosis
Definition
invasion of endometrial glands into the myometrium

dysmenorrhagia, menorrhagia
Term
Adenomysos
risk factors
Definition
endometriosis, uterine fibroids
Term
endometriosis
Definition
implantation of endometrial glands outside of endometrial cavity.

Cyclic pelvic pain that starts 1-2 weeks before menstration.
Abnormal bleeding.

nodular uterus, adnexal mass
Term
endometriosis
diagnosis
Definition
laparoscopy - rusty lesions, choclate cyst
Term
endometriosis
tx
Definition
analgesia
OCP
danazol, leuprolide to decrease FSH LH
Term
PCOS
symptom
Definition
Amenorrhea
Irregular menses
Hirsutism, obesity
Acne
T2D
Term
PCOS
Diagnosis
Definition
pelvic ultrasound
LH:FSH 3:1
Term
PCOS
Tx
Definition
Weightloss
OCP
clomiphene and metformin for those who want to conceive
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