Term
Embryologic structures:
1. in males: ducts that persist under testosterone as genital ducts - epididymis, ductus deferens, ejaculatory duct. in females: degenerate - remnants may persist as broad ligament. in both sexes - help to form the ureter, pelvis, calices, and collecting tubules
2. in males: regression occurs due to antimullerian hormone from sertoli cells - forms appendix testis. in females: differentiation produces uterine tubes, uterus, vaginal wall
3. plays important role in early embryonic circulation, site of primordial germ cells
4. forms at 5th week, midportion of each urogenital ridge thickens as cellular condensation forms this. lacks either testicular or ovarian morphology until 7th week
5. progenitor of urinary bladder, urethra, vagina, and other genitalia
6. gives rise to urogenital system |
|
Definition
1. mesonephric ducts (wolffian)
2. paramesonephric (mullerian) duct
3. yolk sac
4. gonadal ridge
5. urogenital sinus
6. urogenital ridge |
|
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Term
C-Section
1. abdominal incision 2. uterine incision used for previa, transverse lie, preterm delivery, or fetal distress. is the most rapid option. associated with greater blood loss and increased change of uterine rupture in subsequent pregnancies 3. uterine incision associated wtih less blood loss and risk of uterine rupture 4. indications? 5. complications |
|
Definition
1. incision: transverse abdominal most common, others: midline suprapubic
2. classical vertical incision
3. low-transverse incision
4. indications: when vag delivery is not feasible or would impose undue risk, repeat c/s, cephalopelvic disproportion/dystocia, malposition/presentation, fetal distress, placenta previa, preeclampsia, multiple gestation, fetal abnormalities, cervical cancer, active herpes
5. complications: pospartum hemorrhage, endometritis, wound infection, dehiscence |
|
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Term
Hysterectomy - 2nd most common major operation performed in US 1. indications 2. pre-op work up 3. indications for TAH 4. indicaitons for supracervical 5. indicaitons for vaginal 6. indications for LAVH 7. indications for hysterectomy after c/s |
|
Definition
1. indications: tx of gynecological cancer, benign gyn conditions, obstetrical complications
2. pre-op: baseline eval to detect cancer - pap smear w/in 3 mos, bimanual exam, pelvic US, IVP, bowel prep, IV abx before procedure, compression stockings for VTE pro
3. TAH: sx or pelvic findings suggesting adnexal disease, older pts with significant GI complaints, pts wanting additional procedures (liposuction)
4. Supracervical: difficulty dissecting cervix, distorted atatomy due to PID or endometriosis, compromised medical condition. less chance of nerve damage and therefore bladder/orgasmic problems
5. vaginal: gynecoid pelvis w/ wide pubic arch and vaginal apex >2 fingerbreadths, uterine size <280g, significant heart/lung disease
6. LAVH: decreased length of hospital stay, decreased postop analgesia, decrased convalescence, lower complications
7. after c/s: hemorrhage, abnormal placental implantation, uterine atony, inability to repair ruptured uterus, large myomas |
|
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Term
Endometriosis:
1. definition 2. s/s 3. most common site? 4. key words 5. complications 6. treatment |
|
Definition
1. abnormal grwoth of uterine tissue in places other than uterine lining. found almost exclusively in women of reproductive age
2. s/s: red petechial lesions on peritoneal surfaces of pelvic organs - dark brown/blue/black in appearance, pelvic pain during menstrual cycle, infertility, dysmenorrhea, dyspareunia, pelvic pain, premenstrual spotting, uterine motion pain, tender adnexa, abnormal uterine position
3. ovary
4. "choclate cysts", "powder burns"
5. complications: catamenial pneumothorax
6. treatment: expectant management, analgesia, OCPs, progestins, GnRH agonists, aromatase inhibitors, surgery, IVF |
|
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Term
cysts containing well differentiated tissues derived from any 3 germ layers: hair, teeth, ectoderm.
s/s: usually asymptomatic unless torsion or rupture
dx: transvaginal US
tx: laparoscopic removal |
|
Definition
|
|
Term
most common malignant tumor of the ovary an epithelial cancer
85% associated with extraovarian spread at time of dx |
|
Definition
serous cystadenocarcinoma |
|
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Term
high grade squamous intraepithelial lesion (HSIL) of the cervix
1. includes CIN __ & __ 2. s/s 3. labs/tests 4. abnormal colposcopy findings 5. indicaitons for diagnositic conization 6. tx |
|
Definition
1. CIN II and III (moderate and severe dysplasia)
2. s/s: usually non. dx based on bx after abnormal pap
3. labs/tests: repeat cervical cytology q 6 mos until 2 consecutive normals, HPV test, schiller test, colposcopic exam,
4. colposcopy: leukoplakia, hyperkaratosis (white/thickened epithelium), acetowhite epithelium after acetic acid aplication, abnromal vasculature
5. diagnostic conization: unsatisfactory coploscopy, lesions extending into cervical cancal, dysplasia on endocervical curettage, adenocarcinoma, microinvasive carcinoma
6. tx:
- cryotherapy & laswer ablation - cannot produce tissue specimen for histology
- LEEP, cold knife conization, laser cone excision - can do histology |
|
|
Term
fallopian tube: 1. normal length 2. 3 parts 3. blood supply 4. ligamentous support |
|
Definition
1. 7-14 cm
2. isthmus (narrow and straight portion imediately adjoining uterus), ampulla (wider, more tortuous), infundibulum (funnel-like dilation)
3. ovarian and uterine arteries
4. suspensory ligament of ovary suspends infundibulum from pelvic brim |
|
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Term
Stages of fetal development:
1. ovulation of fertilized ovum - travels to uterus to form ____ 2. day 6-7 after ovulation - implantation of ___ 3. day 7-8: ___ proliferation 4. day 9-11: circulation of maternal blood 5. day 13-18: primary and secondary vili form, body stalk, and ____ 6. day 18-21: teritary vili, ___ invades vili, fetoplacental circulation 7. Day 21-40: ___ forms. heart starts beating 8. day 40-50: ___ formation (subdivision of placenta) 9. 8 weeks: 1 g. milestones? 10. 12 weeks: 19 g. milestones? 11. 16 weeks: 100 g 12. 20 weeks: 300 g 13. 24 weeks: 600 g 14. 28 weeks: 1050 g 15. 32 weeks: 1700 g. % viable? 16. 36 weeks: 2500 g. 17. 40 weeks: 3200-3500 g. |
|
Definition
1. blastocyst
2. blastocyst
3. trophoblast
4. maternal blood
5. amnion
6. mesoblast
7. chorionic plate
8. cotyledon
9. 8 weeks - head is half the bulk, hepatic lobes, RBCs, kidneys, ears/eye/nose/mouth/digits, tail almost gone
10. 12 weeks: skin pink, head still large, brain roughly complete, ossification of sarcal arches and bodies
11.16 weeks: sex discernible, hemoglobin F present, hemoglobin A begins, fetus active, heart well developed, lobulated kidneys, meconium in bowel
12. 20 weeks: moving a lot, uterus at umbilicus, sternum ossified
13. 24 weeks: fat deposits, 50% viable, vernix/os/pubis ossifies
14. 28 weeks: lungs functional, low surfactant, nails appear, testes at inguinal ring, talus ossifies
15. 32 weeks: 99% viable
16. 36 weeks: lanugo disappearing, testes in inguinal canal, scrotum small w/ few ruggae, distal femoral ossification centers
17. 40 weeks: silky hair, full testes, pendulous/rugous scrutum, proximal tibia ossificaiton |
|
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Term
Phases of ovarian cycle:
follicular phase: 1. day __: 1 follicle in 1 ovary strts to grow rapidly and becomes dominant follicle 2. day __: ovulation occurs - ovum picked up by fembriated ends of uterine tubes and transported to uterus. if fertilization does not occur, ovum degenerates and passes through uterus out vagina
luteal phase: 3. ___ forms, luteal cells secrete estrogen and progesterone. If pregnancy occurs, it persists. if not, it degenerates
Phases of uterine cycle: 4. ___ phase: day 1-14. restoration of epithelium from preceding menstruation. uterine glands lengthen 5. ___ phase: day 14-28. preparation of uteru for implantation of fertilized ovum. after ovulation, enodmetrium becomes highly vascularized and edematous under estrogen and progesterone . when fertilization fails, endometrium is shed and new cycle starts |
|
Definition
1. day 6
2. day 14
3. corpus luteum
4. proliferative
5. secretory |
|
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Term
menstruation
1. contains? 2. usual duration 3. avg blood loss |
|
Definition
1. contains arterial blood, tissue debris, prostaglandins, fibrinolysin. shouldn't have clots unless excessive flow
2. usual duration: 3-5 days
3. avg blood loss: 30 ml. ranges from spotting to 80 ml
|
|
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Term
Ovulation: 1. definition 2. retrospective indicator of ovulation 3. rise in ___ occurs during rise LH surge - can be detected with at home kits 4. most fertile period? |
|
Definition
1. around day 14, follicular rupture occurs, ovum extruded into abdomen and picked up by fembriated ends of fallopian tubes and transported to uterus
2. rise in basal body tempt
3. urinary LH
4. 48 hrs before ovulation |
|
|
Term
|
Definition
secrete mullerian inhibiting substances to prevent development of uterus, fallopian tubes, and vagina
secrete testosterone to form internal and external genitalia |
|
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Term
Ovarian agensis-dysgenesis disorders:
1. example? 2. s/s? 3. labs: gonadotropin, FSH/LH, estrogen 4. tx? |
|
Definition
1. turner's (45x) or anything with streak gonads
2. s/s: newborns: edema of hands and feet
adolescents: short stature, sexual infantilism, webbed neck, growth retardation
3. labs: elevated gonadotropin, serum FSH >50, LH >90, low estrogen
4. tx: estrogen to assist in development of secondary sex characteristic, growth hormone for height, surgical removal of streak gonads |
|
|
Term
True hermaphroditism
1. definition? 2. s/s 3. tx |
|
Definition
1. presence of ovarian and testicular tissue
2. s/s: ambiguous genitalia, female-type breasts, menstruation, chimeric sex chromosomes (46XY/XX)
3. tx: surgical removal of contradictory organs, reconstruction of external genitalia |
|
|
Term
what disease?
apparent males with small testes, azoospermia, gynecomastia, normal external genitalia, some metnal retardation
s/s usually present wtih puberty
elevated pituitary gonadotropin, low 17-ketosteroid excretion rate
genotype usually 47 XXY
tx? |
|
Definition
klinefelter's
tx: usually none for infertility and gynecomastia
surgery, testosterone, donor sperm |
|
|
Term
What disease?
>2 X chromosomes, mosaicism if 45X gonadal agenesis common s/s: normal body proportions, external genitalia of female, reduced ovarian follicles, small ovaries, irregular menstruation, MR |
|
Definition
|
|
Term
Female hermaphroditism due to congenital adrenal hyperplasia
s/s labs tx |
|
Definition
s/s: greatly enlarged clitoris may be mistaken for penis, no gonads w/in scrotolabial folds
- growth: grow more rapidly early in life but then stop growth about age 10
- virilization begins age 2 - pubic/axillary/body hair, beard, acne, no puberty
- electrolyte imbalance
- no ovulation
labs: high androgens and 17-hydroxyprogesterone
tx: high doses of hydrocortisone + surgical correction of external genitalia |
|
|
Term
male hermaphroditism
cause?
s/s?
labs
tx |
|
Definition
cause: defect in action of testosterone or fxn of testis
s/s: ambiguous genitalia
labs: deficiency in biosynthesis of testosterone
tx: endocrine, surgery, and psych consults |
|
|
Term
Premature ovarian failure
1. definition
2. s/s 3. labs 4. tx |
|
Definition
1. definition: cessation of menses <40 y/o
2. vasomotor flushes, atrophic vaginitis, decreased cervical mucus, osteoporosis
3. labs:
- increase in: LH and FSH
- decrease in : testosterone, estradiol, estrogen, progesterone
4. tx:
- atrophic vaginitis: lubricants, topical estrogens
- vasomotor flushes: estrogens, progestins, clonidine, SSRIs, gabapentin
- osteoporosis: 1200 mg Ca, 400-800 mg vit D, smoking cessation, avoid alcohol, weight-bearing exercise, bisphosphonates (alendronate, risedronate, ibandronate), calcitonin, estrogens, parathyroid hormone, SERMs (raloxifene), progestines |
|
|
Term
what hormone?
secreted by hypothalamus, stimulates anterior pituitary to secrete FSH and LH - normally secreted in episodic bursts to regulate menstrual cycle - thecal cells in ovaries secrete estrogen, which inhibit the release of this hormone |
|
Definition
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Term
Non-hormonal agents that bind to estrogen receptors tx for osteoporosis
ex? |
|
Definition
SERMs - raloxifene, tamoxifene, toremifene |
|
|
Term
HRT 1. OCP benefits 2. indications 3. comlications 4. contraindications |
|
Definition
OCPS: relieve hot flashes and regulate menstrual cycles during perimenopause
Indications: prevention of osteoporosis, tx of hot flashes and vaginal atrophy
Complications: all due to estrogen -endometrial cancer, breast cancer, DVT, stroke, vaginal bleeding, gallbladder dz, dyslipidemia,
Contraindications: undiagnosed abnormal vaginal bleeding, hx breast cancer, hx estrogen-dependent neoplasia, hx DVT/PE, hx MI or CVA, liver disease |
|
|
Term
HRT for each problem:
osteoporosis hot flashes atrophic vaginitis |
|
Definition
osteoporosis: low dose (0.014 mg/d) transderman estrogen
hot flashes: standard dose conjugated estrogen (0.3-0.625 mg/d), 0.025 mg/d transdermal estrogen, or 0.5 mg/d oral estrogen
atrophic vaginitis: 0.25-0.2 g topical estrogen for 2 weeks, then 25 ug estradiol PO for 2 weeks, then weekly, then estradiol ring for 3 months
combined, continuous estrogen + progestin is most common
long term OCP no longer recommended due to cardiovascular risk |
|
|
Term
Presumptive manifestations of pregnancy |
|
Definition
symptoms: amenorrhea, n/v, breast tenderness (mastodynia), breast discharge (colostrum), enlargement of sebaceous glands in areola, quickening, bladder irritability/frequency/nocturia, UTI
signs: increased basal body temp, chloasma (darkening of skin over forehead/cheeks), linea nigra (darkening of nipples and linea alba), stretch marks, spider telangiectaisas |
|
|
Term
When is quickening first felt? |
|
Definition
primi: 18-20 weeks
multi: 14-16 weeks |
|
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Term
hormonal causes of each sx: amenorrhea n/v |
|
Definition
amenorrhea: estrogen/progesterone by corpus luteum
n/v: rapidly rising hCG |
|
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Term
Probable/presumptive manifestations of pregnancy
sx are same as presumptive
signs: 1. bluish/purple discoloration of vagina and cervix 2. vaginal d/c consisting of epithelial cells and cervical mucus 3. widening of softened areas of isthmus 4. 5. 6. 7. softening of anterior wall of uterus 8. softening of cervix |
|
Definition
1. chadwick's sign
2. leukorrhea
3. hegar's sign
4. relaxation of pelvic joints
5. abdominal enlargement
6. uterine contractions
7. Ladin's sign
8. Goodell's sign |
|
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Term
when do braxton hick's begin? |
|
Definition
|
|
Term
positive manifestations of pregnancy
1. fetal heart tones as early as __ weeks. rate __-__ bpm 2. palpation of fetus at __ weeks 3. cardiac activity on US __ weeks 4. limb buds __-__ weeks 5. finger/limb movement __-__ weeks 6. urine pregnancy test: hCG peaks at __-__ weeks, can be detected as early as __ after gestation |
|
Definition
1. FHT: 10 weeks. 120-160
2. Palpation of fetus: 22 weeks
3. cardiac: 5-6 weeks
4. limb buds 7-8 weeks
5. finger movements: 9-10 weeks
6. 10-12 weeks, 1 week |
|
|
Term
gonadotropin secreted from anterior pituitary responsibel for early maturation of ovarian follicle
elevated during follicular phase, peaks at midcycle, decreases during luteal phase |
|
Definition
|
|
Term
Perinatal period = ? number of lives lost during this period are appx equal to number lost during first __ years of life 1/2 occur ___ 70% of deaths in first year of life happen in first __ days |
|
Definition
perinatal period: 28 weeks - first 7 days of life
deaths = first 40 years of life
1/2 occur in utero
70% occur in first 28 days |
|
|
Term
Preterm labor 1. __% idiopathic 2. s/s 3. labs/tests 4. 2 general causes |
|
Definition
1. 50%
2. s/s: uterine contractions > 2/hr, dilation/effacement, vaginal bleeding, bloody show
3. tests: US - gestational age, fetal weight, presenting part, fetal monitoring
CBC w/ diff
UA
amniocentesis - fetal lung maturity
cervical culture: GC/chlamydia
fetal fibronectin - neg test r/o delivery w/in 2 weeks
4. cervical incompetence, preterm uterine contractions
5. tx: bed rest, hydration, corticosterones, tocolysis
|
|
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Term
tocolysis - drugs and purpose |
|
Definition
purpose: delay labor to allow corticosteroids to mature fetal lungs
drugs:
- beta mimetics (terbutaline)
- magnesium sulfate
- calcium channel blockers
- prostaglandin synthase inhibtiors (indomethacin)
try multiple drugs if one fails |
|
|
Term
Premature Rupture of Membranes 1. definition: __ hr elapse of time between rupture and onset of labor. 2. important sequelae? 3. s/s 4. labs/tests |
|
Definition
1. 24 hr
2. chorioamnionitis
3. s/s: hx of gush of fluid from vagina or watery vaginal d/c, sterile speculum exam looking for pooling amniotic fluid in posterior fornix, nitrazine test demonstrating an alkaline pH, presence of ferning when placing fluid on slide and allowed to air dry
4. labs/tests:
CBC w/ diff
UA
US - fetal size, amniotic fluid index
amniocentesis - fetal lung maturity, infection |
|
|
Term
what dx?
fever, maternal leukocytosis, uterine tenderness, tachycardia, foul-smelling amniotic fluid
tx? |
|
Definition
chorioamnionitis
tx: delivery, regardless of gestational age broad spectrum abx oxytocin to induce labor 24-32 weeks: abx, corticosteroids, tocolytics for 48 hrs, then deliver |
|
|
Term
Prolonged pregnancy:
1. definition 2. .most common cause 3. maternal risks 4. labs/tests 5. tx |
|
Definition
1. definition: 42 weeks from first day of LMP or 40 weeks from time of conception
2. most common cuase: incorrect dating
3. maternal risks: fetal size, birth injury, placental insufficiency, olioghydramnios, cord compromise
4. labs/tests:
NST 2x/week
US 2x/week for biophysical profile and amniotic fluid
Mother does fetal movement counts daily
5. tx: expectant managemnet - induction does not decrease c/s rate |
|
|
Term
how does Rh isoimmunization occur?
s/s |
|
Definition
Rh-neg mom gives birth to Rh-pos baby. fetal RBC pass to mom. mom makes abs against Rh antigen.
future pregnancies may develop hemolysis due to maternal antibodies
s/s:
fetal: anemia, immature rbc, high bilirubin, erythroblastosis fetalis
neonate: anemia, hyperbilirubinemia
tx:
screen for ABO and Rh group
28 week visit: ab screening performed, if neg - give 300 ug RhIgG or Rhogam
35 week: repeat ab screening. if pos - manage pt as rh-sensitized
postpartum: if baby is Rh-pos or Du-pos, give Rhogam |
|
|
Term
S/S: pallor, clammy skin, syncope, thirst, dyspnea, restlessness, agitation, anxiety, confusion, falling BP, tachycardia, thread pulse, oliguria --> in third trimester |
|
Definition
hemorrhage
tx:
ABC's
trendelenburg
fetal monitoring
blood transfusion, Ca, K
|
|
|
Term
premature separation of placenta:
1. concealed vs. external 2. risk factors 3. US? 4. tx |
|
Definition
1. concealed: hemorrhae confied within uterine cavity
external: blood drains through cervix
2. risk factors: previous separation, HTN, advanced maternal age, multiparity, vascular disease, smoking, alcohol, cocaine
3. US often inconclusive
4. tx: IV, PRBC, vaginal delivery, c/s if fetal distress |
|
|
Term
placenta previa: 1. risk factors 2. complete vs. marginal 3. s/s 4. tests 5. tx? |
|
Definition
1. risks: multiparity, advanced age, previous c/s, mechanical separation, placentitis, rupture of venous lakes
2. complete: completely covers internal os
marginal: w/in 2 cm of internal os
3. s/s: painless hemorrhage, usually around 28 weeks
4. US
5. tx: expectant - transfusions, tocolysis, test fetal maturity
delivery - c/s is method of choice
6. complications: hemorrhage, shokc, death, bleeding, operative trauma, infection, embolism, prematurity |
|
|
Term
first stage of labor: 1. defition? 2. duration? 3. diet 4. monitor |
|
Definition
1. definition: onset of labor to full cervical dilation
2. duration: primi - 6-18 hr, multi - 2-10 hr
3. sips and ice chips
4. maternal pulse and bp q 2-4 hr
fetal hr q 30 min
uterine contractions q 30 min
cervical dilation |
|
|
Term
second stage of labor: 1. definition 2. duration 3. monitor
steps of fetal progression |
|
Definition
1. fullcervical dilation to delivery of baby
2. duration: primi - 30 min-3 hr
multi: 5-30 min
3. monitor fetal hr q 15 min
fetal progression:
§ Engagement of presenting part: head enters pelvis
§ Flexion: aids in engagement and descent
§ Descent: continues progressively
§ Internal Rotation: rotate to pass the ischial spines
§ Extension: must occur to allow head to bass through vaginal outlet
§ External Rotation: rotates to position it occupied at engagement
· Delivery anterior shoulder: gentle traction downward
· Delivery posterior shoulder: gentle traction upward
|
|
|
Term
third stage of labor 1. definition 2. duration 3. signs of placental separation |
|
Definition
1. definition: delivery of baby - delivery of placenta
2. duration: 0-30 min
3. placental separation: fresh show of blood from vagina, umbilical cord lengthens
fundus raises up
uterus firm and globular |
|
|
Term
___: from delivery of baby and placenta to 6 weeks post-partum |
|
Definition
|
|
Term
|
Definition
combo of cervical dilation, effacement, station, consistency of cervix, position of cervix |
|
|
Term
DEXA scan 1. best test to measure ___ 2. normal, osteopenic, and osteoporotic scores 3. Recommended testing times |
|
Definition
1. bone density
2. normal: T score >-1.0 SD
osteopenic: T score -1.0-(-2.5)
Osteoporotic: T score <-2.5
3. recommendations: postmenopausal <65 y/o
all women >65 y/o
women considering osteoporosis therapy
women on HRT for prolonged therapy
|
|
|
Term
Immunizations during pregnancy: 1. which kids are safe 2. __ is indicated for all women pregnant during october to march 3. 4 vaccines that are ok during pregnancy 4. 3 vaccines that may be given 3 mons prior to pregnancy or postpartum |
|
Definition
1. killed viruses, toxoid, recombinant
2. flu
3. diphtheria, tetanus, hep b, killed polio
4. MMR, polio, varicella |
|
|
Term
Complications assocaited with premature ovarian failure |
|
Definition
definition: spontaeous cessation of menses before 40 y/o
complications & tx:
atrophic vaginitis - topical estrogens
hot flashes - estrogens & progestins
osteoporosis - calcium, vit D, smoking cessation
vaginal dryness/dysparuenia
atrophic cystitis
urethral caruncle w/ dysuria
breast regression |
|
|
Term
Factors that influence labor
1. ___ - when the fetal head settles into the pelvic brim, occurs 2 weeks before labor for 1st pregnancy, at onset for multiparous 2. ___ before labor - cervix begins to soften, efface, and dilate 3. passage of mucus plug = "____" |
|
Definition
1. lightening
2. weeks
3. bloody show |
|
|
Term
Complications of labor 1. occur in __% of nulliparous pts 2. prolonged latent phase - >__ hr. tx? 3. cervical protraction: <__ cm/hr in nulliparous or <__ cm/hr in multiparous 4. protracted descent of fetus: <__ cm/hr in nulliparous or <__ cm/hr in multiparous 5. arrest of dilation: no progressive dilation w/in __ hr 6. arrest of descent: no progress w/in __ hr 7. precipitate labor: delivery <__ hr from onset of contractions 8. precipitate dilation: >__ cm/hr in primi or >__ cm/hr in multi - problems with this? - tx? |
|
Definition
1. 25%
2. >20 hr. tx with bedrest, sedation, or oxytocin
3. cervical protraction: <1.2 cm/hr in nulliparous, <1.5 cm/hr in multiparous
4.protracted descent: <1 cm/h in nulliparous or <2 cm/h in multiparous
5. arrest of dilation: 2 hr
6. arrest of descent: 1 hr
7. precipitate labor: <3 hr
8. precipitate dilation: >5 cm/h primi or >10 cm/hr multi - can cause placental abruption, uterine rupture, PP hemorrhage - tx: stop oxytocin, give terbutaline/ritrodine |
|
|
Term
Pelvic shapes: 1. best for vaginal delivery 2. male type - can cause OP and transverse arrest 3. black > white. can cause transverse arrest 4. most rare. can cause transverse arrest |
|
Definition
1. gynecoid
2. android
3. anthopoid
4. platypelloid |
|
|
Term
Fetal Malpositions: 1. 2 types of vertex malpositions 2. occurs in 0.06%. associated with pelvic contraction, prematurity, and grand multiparity. spotaneously corrects in 1/3. need c-section otherwise. do not use oxytocin 3. occurs in 0.2%. associated wtih grand multiparity, advanced maternal age, pelvic mass, pelvic contraction, multiple gestation, polyhydramnios, macrosomia, congenital anomalies, prematurity, cornual implant, placenta previa, and PROM 4. fetus lies at transverse/oblique angle to maternal long axis. can do external cephalic version (ECV) before labor |
|
Definition
1. occiput posterior and occiput transverse
2. brow presentaiton
3. face presentation
4. abnormal fetal lie |
|
|
Term
birth weight >90th percentile or >4000-4500 g.
risk factors? |
|
Definition
macrosomia
risk factors: maternal DM, obesity, excessive maternal weight gain, postdate pregnancy
risk for shoulder dystocia |
|
|
Term
most common fetal malformation |
|
Definition
|
|
Term
5 obstetrical emergencies |
|
Definition
shoulder dystocia
fetal compromise
placenta previa
fetal blood loss
vasa previa |
|
|
Term
inability to deliver shoulders after the head
associated with macrosomia, dm, prolonged 2nd stage of labor, instrumental delivery -- if any of these are present, pt should be offered a c/s
what to do: 1. call for help 2. episiotomy 3. mcroberts maneuver 4. rubin maneuver 5. wood's maneuver 6. barnum maneuver |
|
Definition
|
|
Term
fetal compromise 1. definition
2. what to do? |
|
Definition
1. decreased fhr or decrease in variability
2.
a. vaginal exam
b. mom to lateral position for intrauterine resuscitation
c. correct maternal hypotension
d. stop oxytocin
e. deliver |
|
|
Term
hallmark: painless vag bleeding during 2nd or 3rd trimester
tx? |
|
Definition
placenta previa
DO NOT DO CERVICAL EXAM
needs c/s
|
|
|
Term
vaginal bleeding + FHR abnormalities |
|
Definition
placental abruption --> deliver immediately |
|
|
Term
normal fetoplacental vascular volume
signs that fetus has lost blood
test to determine fetal hgb? |
|
Definition
250-500 ml
fetal tachy, recurrent decels, prolonged brady, sinusoid pattern
kleihauer-betke test |
|
|
Term
when umbilical vessels cross internal os in advance of fetal persenting part - likely to be disrupted during labor, causing fetal bleeding
dx: fetal tachy after rupture of membranes
tx? |
|
Definition
vasa previa
tx: emergency c/s |
|
|
Term
DM in pregnancy increases risk of.... |
|
Definition
spontaneous abortion
congenital anomalies
macrosomia
shoulder dystocia
operative delivery
birth trauma
neonatal hypoglycemia
resp distress syndrome
hypocalcemia
hyperbilirubinemia
fetal malformations due to hyperglycemia occur in first 8 weeks of pregnancy, so all DM pts should recieve periconceptional care |
|
|
Term
maternal glucose levels in 1st trimestr vs. 2nd and 3rd |
|
Definition
1st trimester: estrogen and progesterone cause decreased fasting glucose
2nd/3rd: decreased insulin sensitivity
|
|
|
Term
managing breech presentaiton |
|
Definition
>36 weeks - external cephalic version
c/s if not corrected |
|
|
Term
role of glucocorticoids during pregnancy |
|
Definition
given over 48 hrs to accelerate fetal lung maturation |
|
|
Term
|
Definition
uterine, adnexal, or cervical motion tenderness and absence of competing dx
PLUS one of these:
>38.3C or 101F
increased ESR
increased WBC
inflammatory mass
gram neg intracellular diplococci |
|
|
Term
PID 1. most common agents 2. always r/o what two things? 3. workup? 4. risk factors 5. tx |
|
Definition
1. gonorrhea or chlamydia
2. r/o ectopic and appy
3. pelvic US, UPT, CBC, ESR, genital cultures, UA
4. risk factors: multiple partners, young, nulliparous, non-white, douching, smoking, IUD
5. cefoxitin IM + probenecid PO + ceftriaxone IM |
|
|
Term
Gardnerella vaginalis: 1. results from loss of natural ___ bacteria 2. clinical criteria? 3. tx |
|
Definition
1. lactobacilli
2. homogeneous white d/c, microscopic presence of >20% clue cells, vaginal d/c with pH > 4.5, fish odor
3. Flagyl PO, clinda cream, or flagyl cream |
|
|
Term
Ovarian Cysts 1. characteristics of benign cysts 2. characteristics of malignant cysts 3. workup |
|
Definition
1. benign: smooth, mobile, <10 cm, calcium, painless
2. malignant: fixed, solid, septation >3mm, ascites, abd pain, bloating, nausea, early satiety, munstraul abnormalities
3. workup: US, CBC, CMP, hCG, CA-125, AFP, LDH |
|
|
Term
cyst that is part of the normal menstrual cycle. should not be painful. rupture wtih ovulation.
cysts >6cm should be followed with US to make sure they disappear |
|
Definition
|
|
Term
Side effects of oral contraceptives |
|
Definition
increased risk of MI, DVT, CVD, cervical dysplasia, HTN, HA, decreased quality/quantity of breast milk, depression, nausea/dizziness, weight gain 2-5 lbs, fatigue, decreased libido |
|
|
Term
contraindications to steroid contraceptives |
|
Definition
absolute: pregnancy, dvt, CAD, breast ca, undiagnosed abn vag bleeding, estrogen-dependent ca, liver tumor, uncontrolled htn, DM, >35 y/o and smoking >15 cig/day, thombophillia, migraine w/ aura, acitive hepatitis, surgery requiring prolonged imobilization |
|
|
Term
1. ~__% of pts with BRCA1 will develop breast cancer 2. ~__% of pts wtih BRCA2 will develop breast cancer 3. when is BRCA screening indicated? |
|
Definition
1. 85%
2. 40%
3. screening: dx with breast ca <40 y/o, 1st deg relative with breast ca <50, women w/ family hx of male or multiple breast cancers, sngnificant neoplasms (ovarian, colon, pancreatic) |
|
|
Term
Characterized by chronic anovulation, polycystic ovaries, hyperandrogenism associated wtih hirsutism, obesity, insulin resistance increased risk of DM, CVD, metabolic syndrome
workup? tx? |
|
Definition
PCOS
workup: FSH, LH, prolactin, TSH - to r/o other causes
testosterone, 17-hydroxyprogesterone
tx:
exercise, weight loss, metformin
clomiphene: infertility
OCPs: hirsutism |
|
|
Term
basis of female infertility with aging |
|
Definition
less frequent ovulation + lower quality eggs
|
|
|
Term
hormones involved in breast feeding |
|
Definition
estrogen, progesterone, prolactin, GH, insulin, cortisol, epithelial growth factor
prolactin is stimulated by suckling, nipple stimulation, crying infant, positive attitude |
|
|
Term
germ cell tumor that is rubbery, smooth, round, and encapsulated wtih brown/gray color
AFP is borderline high hCG may be pos or neg |
|
Definition
|
|
Term
germ cell tumor composed of any of the 3 germ cell layers may have hair and teeth account for 40-50% of benign ovarian neoplasms in reproductive age women and are usually asymptomatic unless complications such as torsion/rupture occur
usually found in women <20 AFP +/- hCG negative
AKA dermoid cysts
dx via US removed laparoscopically
which are malignant? |
|
Definition
ovarian teratoma
immature teratomas are malignant, mature are benign
|
|
|
Term
potential causes of elevated hCG w/ empty uterus |
|
Definition
ectopic
ovarian tumors: dysgerminoma, mixed germ cell tumor, choriocarcinoma, embryonal carcinoma |
|
|
Term
Mastitis: 1. cause 2. sx 3. tx 4. what does recurrent mastitis suggest? |
|
Definition
1. staph
2. fissured, red, warm, sore nipple
3. tx: dicloxacillin or cephalosporin, keep nursing, stop if abscess
4. recurrent = neonatal strep infx |
|
|
Term
PMS: 1. definition 2. management 3. ___: if sx disrupt daily fxn |
|
Definition
1. 7-14 d before menstruation - should quit w/ menstruation
2. pt chart sx, diet and avoid triggers, Ca/Mg/B6/Vit E/NSAIDS, SSRI, OCP
3. PMDD |
|
|
Term
Breast cancer: 1. __ leading cause of cancer death in women 2. 1/_ lifetime risk 3. risk factors? 4. early findings 5. late findings 6. breast exam recs 7. mammogram recs 8. what to do if you find a lump? 9. most malignant form? 10. tx? |
|
Definition
1. 2nd
2. 1/8
3. risk: delayed childbearing (>35), fm hx, BRCA 1 or 2, personal hx of breast cancer, mecarch <12, menopause >50
4. early: single, nontender, firm mass with ill defined margins; mammogram abn w/ no palpable mass
5. late: skin/nipple retraction, axillary adenopathy, breast enlargment, erythema, edema, pain, fixation of mass to skin or chest wall
6. breast exam: 20-40 y/o every 2-3 years, >40 yearly
7. mammogram: >40 1-2 years, >50 yearly
8. lump - diagnostic mammogram
9. most malignant: inflammatory
10. tx: surgery + adjunctive therapy. just palliative if stage IV, mammogram q 6 mos for 2 yr |
|
|
Term
LOOK UP BREAST CANCER BY QUADRANT |
|
Definition
|
|
Term
most common cause of post-menopausal bleeding |
|
Definition
|
|
Term
1. inability of a couple to conceive w/in 1 year 2. those who have never conceived 3. probability of achieving live birth w/in 1 menstrual cycle 4. likelihood of conception per month of exposure
__% of couples having unprotected sex will conceive w/in 1 yr |
|
Definition
1. infertility/subfertility: inability of a couple to conceive w/in 1 year 2. sterility: those who have never conceived 3. fecundity: probability of achieving live birth w/in 1 menstrual cycle 4. fecundibility: likelihood of conception per month of exposure
90% |
|
|
Term
4 key things to test for infertility |
|
Definition
male sperm analysis
oocytes
egg stransport
implantation of ova
|
|
|
Term
Male infertility: 1. majority are due to ? 2. normal semen analysis: count, motility, volume, morphology |
|
Definition
1. testicular pathology - varicocele
2. count: >20M/ml
motility: >50%
volume: >2 ml
Morphology: >30% normal |
|
|
Term
Female infertility: 1. workup 2. check FSH and estradiol on cycle day __, check progesterone on day __ 3. sx of cervical cause of infertility 4. tx plan |
|
Definition
1. pelvic US, urinary LH, basal body temp, endometrial bx, cervical mucus, hysterosalpingogram, sonohysterogram, laparoscopy w/ chromointubation (gold standard for assessing tubes)
2. FSH/estradiol: day 3, progesterone day 21
3. hx abnormal pap, post-coital bleeding, cryotherapy, conization, DES exposure
4. clomid (starting day 3-5 of cycle for 5 days) --> hCG + IUI --> IVF |
|
|
Term
Drug Classes in Pregnancy:
1. animal studies have shown adverse effect on fetus but no adequate studies in humans; benefits may outweigh risks 2. aequate studies in pregnant women fail to show risk to fetus 3. animal/human studies shown fetal abnormalities or toxicity, risks outweigh benefits 4. pos evidence of human fetal risk, benefits may outweigh risks 5. animal studies failed to show risk but no adequate human studies - or animal studies show risk but human studies don't |
|
Definition
|
|
Term
measuring uterine size during pregnancy: 1. size of your fist 2. smaller than fist 3. palpable at pubic symphysis 4. palpable at umbilicus 5. palpable at xiphoid |
|
Definition
1. not pregnant
2. nulliparous
3. 12 weeks
4. 20 weeks
36 weeks |
|
|
Term
mucopurulent d/c + bleeding |
|
Definition
|
|
Term
abortions: 1. most common complication of pregnancy 2. in 20-30% of pts in first trimester 3.abdominal/back pain + bleeding with open cervix 4. severe/persistent bleeding + cramps |
|
Definition
1. spontaneous abortion
2. implantation bleed
3. inevitable abortion
4. incomplete abortion
|
|
|
Term
potential causes of 3rd trimester bleeding (7) |
|
Definition
bloody show
placenta previa
vasa previa
placental abruption
DIC
uterine rupture
non-OB (cervical pathology, vaginal pathology) |
|
|
Term
most common cause of non-OB maternal death in pregnancy? most common cause of fetal death? |
|
Definition
MVA
death of mother, placental abruption |
|
|
Term
Pre-eclampsia: 1. classic diagnostic triad, PE 2. bimodal peak 3. kidney damage 4. tx for mild 5. tx for severe |
|
Definition
1. htn, edema, proteinuria, PE: brisk patellar reflexes, clonus
2. young nulliparous and >35 multiparous
3. kidneys: glomeruloendotheliosis
4. mild: <37 weeks: corticosteroids + bed rest
>37 weeks - induction
5. severe: <24-34 weeks: corticosteroids + mag sulfate
>34 weeks: delivery |
|
|
Term
|
Definition
risks: tonic clonic seizure
tx: ABCs, diazepam/lorazepam, deliver baby! |
|
|
Term
HELLP syndrome: 1. definition 2. sx 3. tx |
|
Definition
1. variant of pre-eclampsia characterized by: Hemolysis, Elevated Liver enzymes, and Low Platelets
2. sx: RUQ pain, malaise, n/v
3. tx: delivery then dexamethasone |
|
|
Term
nutrition during pregnancy: 1. Protein 2. calcium iron folic acid |
|
Definition
protein: 1 g/kg/d + 20 g/d --> appx 80 g/day
calcium: 1.5 g/day
iron: 30 mg/day
folic acid: 4 mg/d if prior NTD, 0.4 mg/d if not |
|
|
Term
Condyloma acuminate: 1. cause 2. incubation 3. lesions 4. sx 5. bx 6. tx |
|
Definition
cause: HPV
incubation: >3 mos
lesions: papillary growths that coalsece into cauliflower masses, tend to proliferate during pregnancy
sx: pruritis, vaginal d/c, post-coital bleeding
bx: koliocytes
tx: trichloracetic or bichloracetic acid (TCA or BCA), podophyllin gel, cryosurgery/electrocoagulation |
|
|
Term
Androgen insensitivity syndrome:
1. definition 2. presents as ____ 3. What organs does the pt have and not have? 4. tx? |
|
Definition
1. testicular feminization with 46.XY genotype due to deficeincy in androgen-binding protein --> creates male hermaphroditisim
2. presents as amenorrhea
3. has vulva and breasts secondary to unopposed estrogen but no uterus or vagina or body hair bc body is not responseive to testosterone. testes made by mullerian inhibiting factor = mullerian agenesiis
4. tx: address gender identification and remove undescended testes |
|
|
Term
When germ cells fail to migrate from yolk sac to genital ridge in embryonic development, ___ occurs and the pt will have a female phenotype and male genotype. the result is a non-fxnal "____ ____"
what genitalia will they have? |
|
Definition
female genitalia including vagina and uterus + streak gonads |
|
|
Term
What does aromatase do? what are aromatse inhibitors? |
|
Definition
converts testosterone to estrogen
aromatase inhibitors (anastrozole, etrozole) and inactivators (exemestane) block conversion of androgens to estrogens --> good for breast cancer |
|
|
Term
Cervical cancer risk factors |
|
Definition
multiple partners, early onset of sexual activity, high risk sexual partners, HPV infection, hx STDs, smoking, HIV, AIDS, multiparity, long term OCP use
condoms do not entirely protect against HPV - can be transmitted from scrotal-labial contact
|
|
|
Term
Gestational DM
1. definition 2. complications 3. tx
glucose goals: 1. fasting 2. 1 hr post-prandial 3. 2 hr post-prandial |
|
Definition
1. any degree of glucose intolerance w/ onset during pregnancy
2. complications: macrosomia, polyhydramnia, miscarriage, fetal malformation, hypoglycemia in baby, preterm birth, pyelo, preeclampsia, in utero meconium, fetal hr abn, c/s, still birth
3. tx: BG control, non-weight bearing/low-impact exercise, diet 1800-2400 cal/day, insulin, birth 38-39 weeks
1. 70-95 fasting
2, <140 1 hr pp
3. <120 2 hr pp |
|
|
Term
most common cause of asymptomatic bacteruria? |
|
Definition
|
|
Term
urinary frequency, dysuria, urgency, suprapubic discomfort, cloudy/malodorous urine |
|
Definition
|
|
Term
fever, shaking chills, flank pain, n/v, ha frequency, dysuria, bacteria endotoxiemia, endotoxic shock, renal insuff, anemia, leukocytosis, thrombocytopenia, elevated fibrin split products, preterm labor, fetal death, pulmonary dysfunction, ARDS |
|
Definition
|
|
Term
anovulation: 1. which hormone isn't working? 2. usually a dysfunction of ___ 3. organic causes? 4. sx? |
|
Definition
1. progesterone
2. hypothalamic pituitary axis
3. thyroid/adrenal dysfunction
4. irregular bleeding, absence of ovulatory temp changes, low serum progesterone |
|
|
Term
what happens to AFP levels in NTD and Down's? |
|
Definition
NTD: high maternal serum levels
Down's: decreased levels + increased hCG |
|
|
Term
Amenorrhea 1. three things that must be intact for normal menstruation 2. primary amenorrhea 3. secondary amenorrhea 4. most common cause of secondary amenorrhea 5. workup? |
|
Definition
1. hypothalamic-pitutiary axis, endometrium responsive to horomes, outflow tract from internal to external genitalia
2. absence of menses by age 15
3. absence of menses for 3 cycles or 6 mos
4. pregnancy
5. PREGNANCY TEST, TSH, prolactin, pelvic exam (establish presence of organs), US, serum testosterone |
|
|
Term
causes of menorrhagia (hypermenorrhea) |
|
Definition
tumor
myoma
pregnancy complication
IUD
hyperplasia
dysfunctional bleeding
|
|
|
Term
Galactorrhea: 1. most common causes in non-lactating women?
DDX: a. unilateral serous or serous-sanguineous d/c b. premenopausal, spontaneous, multiple ducts, green/brown, unilateral/bl, increased before menses c. milky d. purulent |
|
Definition
1. carcinoma, intraductal papilloma, fibrocystic changes
a. intraductal papilloma or malignancy
b. fibrocystic changes
c. prolactinemia or OCP
d. subareolar abscess |
|
|
Term
most common reportable disease sx: may be asymptomatic, may have mucopurulent d/c, hypertrophic cervical inflammation, salpingitis
dx: cell culture, geimsa stain
tx? |
|
Definition
chlamydia
tx: doxy or azithromycin
pregnancy: erythromycin or amoxicillin |
|
|
Term
gram neg diplococci 20-40% co-infection w/ chlamydia
discharge, urinary frequency, dysuria, rectal pain, vaginal itching/burning bartholinitis pharyngitis conjunctivitis
dissemination: polyarthralgia, tenosynovitis, dermatitis
labs: thayer-martin stain |
|
Definition
gonorrhea
reportable
tx: ceftriazone/cefixime + doxy or azithromycin |
|
|
Term
Candida:
1. conditions associated 2. sx 3. dx 4. tx |
|
Definition
DM, HIV, obesity, pregnancy, abx, steroids, OCP, debilitation
pruritus, white/cheesy d/c, vulvuar erythema, burning w/ urination
KOH prep
culture is gold standard
tx: nystatin PO or cream, clotrimazole/ketoconazole/fluconazole |
|
|
Term
unicellular flagellate protozoan that infections lower urinary tract in men and women sx: persistent frothy green vaginal discharge +/- pruritus, strawberry spots on vag epithelium
tx? |
|
Definition
trichomonas
tx: metronidazole x 1 |
|
|
Term
painless sore/chancre on labia/vag/cervix/anus + painless lymphadenopathy
tx? |
|
Definition
primary syphilis
tx: benzathine pcn G IM x 1, tetracycline or doxy for 14d for PCN allergy |
|
|
Term
systemic infx w/ diffuse adenopathy, papulosquamous rash on palms, soles, trunk; alopecia, hepatitis, nephritis, condyloma lata
tx? |
|
Definition
secondary syphilis
tx: benzathine PCN G |
|
|
Term
syphilis of <1 yr duration with primary and secondary lues still contagious tx? |
|
Definition
latent syphilis
tx: benzathine PCN G |
|
|
Term
indeterminate or >1 yr syphilis |
|
Definition
late latent syphilis
get CSF study to r/o neurosyphilis
|
|
|
Term
Congenital syphilis sx?
will baby's test be reactive |
|
Definition
always systemic disease - organomegaly, osteochondritis, anemia, jaundice, skin lesions, rhinitis, adenopathy, CNS disease
baby's test is reactive
tx: put baby in isolation, treat if rising titer
treat mom before 18 weeks to prevent transmission |
|
|
Term
caused by chlamydia species
vesiculopustular eruption vaginal ulceration, lymphedema excrutiating pain red-purple induration rectal stricture makes defecation difficult vaginal distortion = dyspareunia late phase: fever, chills, HA, arthralgia |
|
Definition
lymphogranuloma venereum
tx: REPORT
- doxy or erythrombycin for 21 days |
|
|
Term
cause: calymmatobacterium granulomatis
malodorous d/c, inguinal swelling, abscess (bubo)
large macrophages w/ rod-shaped inclusions (MIKULICZ CELLS and DONOVAN BODIES)
tx? |
|
Definition
granuloma inguinale (donovanosis)
tx: bactrim or doxy x 3 weeks --> NOT PCN |
|
|
Term
organism: H. ducreyi (gram neg rod)
sx: inguinal adenitis w/ erythema and fluctuance, vesiculopustular lesions becoming saucer-shaped ragged ulcer w/ inflammatory wheal. very tender, foul d/c, adenitis, buboes
tx? |
|
Definition
chancroid
tx: report
r/o syphilis
sitz baths, azithromycin + ceftriaxone + erythromycin + cipro |
|
|
Term
Herpes Simplex
1. incubation 2. how long do lesions last? 3. testing? |
|
Definition
incubation: 2-7 d
lasts 2-6 weeks
tzanck smear
|
|
|
Term
congenital herpes:
1. __% transmission rate 2. infx in newborn has __% mortality rate 3. __% of survivers have neurologic/ocular sequelae 4. initiate antiviral therapy at __ weeks gestation |
|
Definition
1. 40-50%
2. 60%
2. 50%
4. 36 weeks |
|
|
Term
cause: HPV incubation: >3 mos sx: papillary growths coalescing into cauliflower masses pruritus, vaginal d/c, post-coital bleeding
bx: koliocytes
tx? |
|
Definition
condyloma acuminate
tx: trichloaracetic or bichloracetic acid (TCA or BCA), podophyllin gel, cryosurgery/electrocautery |
|
|
Term
physiologic changes during pregnancy
1. thick vaginal d/c 2. heart 3. resp 4. heme 5. renal 6. gi 7. msk, pubic symphysis separates at __ weeks 8. colostrum at __ weeks |
|
Definition
1. leukorrhea of pregnancy
2. CO increase by 30-50%, SEM
3. 20% increased need for O2
4. 35% increase in blood volume
5. decreased bladder tone and capacity, NOT proteinuria
6. n/v/pica/gerd/constipation
7. progesterone = laxity of ligaments, pubic symphysis at 28-30 weeks
8. 16 weeks
|
|
|
Term
|
Definition
repeat
cephalopelvic disproportion/dystocia
malposition/malpresentation
fetal distress
placenta previa/multiple gestation/fetal abnormalities, cervical cancer, active herpes |
|
|
Term
Indications for hysterectomy |
|
Definition
treatment of cancer
benign GYN conditions (endometriosis, dysmenorrhea, menorrhagia)
obstetric complications |
|
|
Term
Endometriosis ** 1. early vs. advanced lesions 2. most common place for lesions 3. three most common presenting sx 4. tx |
|
Definition
1. early: red petechial lesions. later: dark brown/blue endometriomas or "chocolate cysts"
2. ovary
3. infertility, dysmenorrhea, dyspareunia
4. expectant management, nsaids, OCP, progestins, danazol, GnRH agnoists (leuprolide), hysterectomy |
|
|
Term
what tumor?**
malignant tumor of ovary histologically: budding tufts, PSAMMOMA BODIES
sx: insidious onset, long-standing hx of non-specific abd pain, GI complants, dyspepsia, altered bowel habits
tx? |
|
Definition
serous cystadenocarcinoma
tx: surgery |
|
|
Term
Cervical dysplasia of CIN 2 or 3. tx with LEEP do colposcopy first |
|
Definition
high-grade squamous intraepithelial lesion (HSIL) |
|
|
Term
what hormone spikes before egg is released? ** |
|
Definition
|
|
Term
spontaneous cesseation of menses <40 y/o climacteric sx: hot flushes, secondary amenorrhea HIGH FSH |
|
Definition
premature ovarian failure/premature menopause |
|
|
Term
clinical presentaiton of ____: - ambiguous genitalia micropenis clitoromegaly partial labial fusion undescended testes labial/inguinal masses in girls hypospadias delayed/absent puberty electrolyte abn |
|
Definition
|
|
Term
what hormone? **
released in pulsatile fashion from hypothalamus - modulates secretion of gonadotropin is measured by measuring LH
agonists of this hormone (Leuprolide) are used for tx of endometriosis |
|
Definition
|
|
Term
normal pregnant woman who is not anemic requires supplementation of ___ mg/d iron |
|
Definition
|
|
Term
severe NVP in pregnancy, which can result in weight loss, ketonuria, and electrolyte imbalance
due to hCG increase |
|
Definition
|
|
Term
hormone responsible for maturation of ovarian follicles *** |
|
Definition
|
|
Term
hormone that triggers ovulation and the initial formation fo the corpus luteum as well as secretion of estrogen and progesterone |
|
Definition
|
|
Term
Stages of labor **
1. begins with contractions - to achieve dilation and effeacement - ends with full dilation
2. irregular to regular contractions with little/no progress
3. regular progress expected, failure to progres is potential problem
4. from full dilation to delivery of baby
5. placental delivery |
|
Definition
1. first stage
2. latent phase
3. active phase
4. second stage
5. third stage |
|
|
Term
third trimester bleeding *** 1. painless bleeding 2. painful bleeding |
|
Definition
1. placenta previa -- do not do cervical exam
2. abruptio placentae |
|
|
Term
what imaging is used for the most accurate dx of osteoporosis? ** |
|
Definition
|
|
Term
Vaginal Discharge: ** 1. Muco-purulent (mucous + pus) cervicitis with hypertrophic cervical inflammation= Chlamydia 2. Purulent (pus) vaginal d/c and dysuria = gonorrhea (but most are asymptomatic) 3. Frothy greenish discharge sometimes foul smelling; “strawberry cervix” = trichomonas 4. “Cottage cheese” looking d/c with severe itching = yeast 5. White/gray thin or watery d/c that is “fishy” smelling = bacterial vaginosis |
|
Definition
1. chlamydia
2. gonorrhea
3. trichomonas
4. yeast
5. bacterial vaginosis |
|
|
Term
Most common cause of infertility? ** |
|
Definition
sperm
Tubal and pelvic pathology make up 35% |
|
|
Term
essential workup for infertility ** |
|
Definition
HEST: health, eggs, sperm, tubes |
|
|
Term
hormone replacement therapy increases risk of cancers only if .... ** |
|
Definition
|
|
Term
what is "ferning" in regard to cervical fluid analysis during pregnancy? |
|
Definition
if cervical fluid is collected and a nitrazine test is done and ferning is demonstrated, the fluid is amniotic = PROM |
|
|
Term
|
Definition
a tocolytic
started if hx of preterm birth, positive fibronectin, short cervix, changing dilation
allows for corticosteroid administration for 48 hrs |
|
|
Term
BP drugs to discontinue during pregnancy |
|
Definition
|
|
Term
BP > 140/90 on 2 or more occasions with no proteinuria |
|
Definition
|
|
Term
Gestational trophoblastic disease:
1. non-viable pregnancy due to trophoblastic neoplasia, in very old and very young. paternal genoma 46 YY. very high hCG, hyperemesis gravidarum, uterus large for date, early pre-eclampsia. tx?
2. trophoblastic malignancy |
|
Definition
1. hydatidiform more. tx: suction curettage, monitor hCG for 1 year
2. choriocarcinoma |
|
|
Term
first trimester bleeding + cramping/knife-like one sided pelvic pain + normal/low hCG
tx |
|
Definition
ectopic
get US
tx: methotrexate IM, laparotomy for rupture |
|
|
Term
risk factors for placenta abruption |
|
Definition
high parity
hypertension
hx previous abruption |
|
|
Term
What level are these amenorrhea problems coming from?
Loss of GnRH Psychological stress Low body fat: anorexia, exercise Congenital GnRH problems
Hyperprolactinemia Pituitary adenoma Hypothyroidism Drug induced Idiopathic |
|
Definition
hypothalamic/pituitary level
|
|
|
Term
at what level is there a problem causing amenorrhea?
Congenital Abnormality Primary amenorrhea due to ovarian dysgenesis, Turner’s syndrome
early menopause Idiopathic Secondary |
|
Definition
|
|
Term
intrauterine synechiae caused by infection caused by instrumentation |
|
Definition
|
|
Term
4 general causes of amenorrhea |
|
Definition
hypthalamic/pituitary axis
ovarian
uterine
metabolic |
|
|
Term
|
Definition
fibroids (leiomyoma)
PCOS
coagulopathy |
|
|
Term
bilateral inflammation of fallopian tubes caused by STDs. can progress to tubo-ovarian abscess
presents as bilateral abd cramping, fever, leukocytosis, mucopurulent cervical d/c
cervical motion tenderness is classical finding |
|
Definition
salpingitis - a form of PID |
|
|
Term
sudden, severe, unilateral abdominal pain, maybe nausea pt can't find comfortable position |
|
Definition
ovarian torsion
tx: knee-chest position
laparoscopy |
|
|
Term
causes of secondary dysmenorrhea |
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Definition
endometriosis
adenomyosis
leiomyoma
outflow obstruction |
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Term
endometrial galnds and stroma with the myometrium
sx: dysmenorrhea, menorrhagia - frequent, irregular, heavy periods
large, boggy, tender uterus
tx? |
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Definition
adenomyosis
tx: nsaids, ovarian suppression, surgery |
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Term
Big 3 causes of vaginitis |
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Definition
monilia (Candida)
trichomonas
Bacterial vaginosis (gardnerella) |
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Term
methods for preventing ovulation |
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Definition
supress gonadotropin
oral contraceptives
steroids (depo)
GnRH analogs (Lupron) |
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Term
ovulation testing:
1. day 3 2. day 21 |
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Definition
day 3: estradiol (should be <80) and FSH (Should be <10)
day 21: progesterone should be >9 |
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Term
Most common bone disorder in the U.S. Implicated in 1.4 million fractures per year Much more common in women More common in white women than blacks Thin more common than heavy Bone density falls over time from peak at age 35 Men start with higher bone density Risk factors: Genetics Smoking Poor calcium intake 700 mg of Ca a day + normal diet is sufficient Early menopause due to longer absence of estrogen Young woman who undergoes early menopause definitely needs to be on HRT |
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Definition
involutional osteoporosis |
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Term
Alendronate (Fosamax) Risedronate (Actonel) Etidronate (Didronel) Pamidronate (Aredia) Tiludronate (Skelid) Zoledronate (Zometa) |
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Definition
bisposphonates - used for osteoporosis |
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Term
20 y/o with ovarian cancer... what kind? |
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Definition
most likely germ cell - dysgerminoma or choriocarcinoma |
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Term
postmenopausal woman that presents with bleeding has ___ until proven otherwise |
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Definition
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