Term
|
Definition
gain of function
CML
Tyrosine Kinase |
|
|
Term
|
Definition
Gain of function
Burkitt's Lymphoma
Transcription factor |
|
|
Term
|
Definition
gain of function
Follicular and undifferentiated lymphomas
Anti-apoptotic molecule |
|
|
Term
|
Definition
gain of function
Breast, ovarian, and gastric carcinomas
Tyrosine Kinase
Tx: Transtuzumab |
|
|
Term
|
Definition
gain of function
colon carcinoma
GTPase, part of MAP-kinase system. Promotes mitogenesis
|
|
|
Term
|
Definition
gain of function
Lung tumor(small cell)
Transcription factor
|
|
|
Term
|
Definition
gain of function
Neuroblastoma (adrenal)
Transcription factor
|
|
|
Term
|
Definition
gain of function
MEN types IIA and IIB, medullary carcinoma of thyroid and papillary
Tyrosine kinase (causes growth)
|
|
|
Term
|
Definition
gain of function
Gastrointestinal stromal tumor (GIST)
Cytokine receptor
|
|
|
Term
|
Definition
loss of function
retinoblastoma, osteosarcoma
chrom 13
Blocks G1 --> S phase of cell cycle |
|
|
Term
|
Definition
loss of function
most human cancers, Li-Fraumeni sydrome
chrom 17
blocks G1 --> S phase of cell cycle
|
|
|
Term
|
Definition
loss of function
Breast and Ovarian Cancer
chrom 17
DNA repair protein
|
|
|
Term
|
Definition
loss of function
breast cancer in both sexes
chrom 13
DNA repair protein
|
|
|
Term
|
Definition
loss of function
Melanoma
|
|
|
Term
|
Definition
loss of function
colorectal cancer (a/w FAP)
chrom 5
|
|
|
Term
|
Definition
loss of function
Wilms' tumor
chrom 11
PAX 6 develops iris -> aniridia becaues right nect to Wilms' tumor gene
|
|
|
Term
|
Definition
|
|
Term
|
Definition
loss of function
Colon cancer
|
|
|
Term
|
Definition
loss of function
renal cell carcinoma, hemangioblastoma
|
|
|
