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Details

oncogenes & tumor supressor genes
name function (general) & what tumor they are associated w/
21
Agriculture
10th Grade
03/03/2012

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Cards

Term
abl
Definition
ONCOGENE
Associated tumor: CML (BCR-abl)

Gene product: Tyrosine kinase
Term
c-myc
Definition
ONCOGENE
Associated tumor: Burkitt's lymphoma

Gene product: Transcription factor
Term
bcl-2
Definition
ONCOGENE
Associated tumor: Follicular & undifferentiated lymphomas (inhibits apoptosis)

Gene product: anti-apoptotic molecule
Term
erb-B2
Definition
ONCOGENE
Associated tumor: Breast, ovarian, and gastric carcinomas

Gene product: tyrosine kinase
Term
ras
Definition
ONCOGENE
Associated tumor: colon carcinoma

Gene product: GTPase
Term
L-myc
Definition
ONCOGENE
Associated tumor: Lung tumor

Gene product: Transcription factor
Term
N-myc
Definition
ONCOGENE
Associated tumor: neuroblastoma

Gene product: Transcription factor
Term
ret
Definition
ONCOGENE
Associated tumor: MEN IIA & IIB

Gene product: tyrosine kinase
Term
c-kit
Definition
ONCOGENE
Associated tumor: GIST

Gene product: Cytokine receptor
Term
Rb
Definition
TUMOR SUPPRESSOR GENE
Location: 13q

Associated tumor: Retinoblastoma; osteosarcoma

Gene product: Rb gene product blocks G1 --> S phase of the cell cycle
Term
p53
Definition
TUMOR SUPPRESSOR GENE
Location: 17p

Associated tumor: most cancers; Li-Fraumeni syndome

Gene product: blocks G1 --> S phase of cell cycle
Term
BRCA1 (17q)
Definition
TUMOR SUPPRESSOR GENE
Location: 17q

Associated tumor: Breast & ovarian

Gene product: DNA repair
Term
BRCA2
Definition
TUMOR SUPPRESSOR GENE
Location: 13q

Associated tumor: Breast cancer

Gene product: DNA repair
Term
p16
Definition
TUMOR SUPPRESSOR GENE
Location: 9p

Associated tumor: Melanoma

Gene product: inhibits cell cycle progression (CDK inhibitor)
Term
APC
Definition
TUMOR SUPPRESSOR GENE
Location: 5q

Associated tumor: colorectal cancer (FAP)

Gene product: inhibits beta-catenin signaling
Term
WT1
Definition
TUMOR SUPPRESSOR GENE
Location: 11p

Associated tumor: Wilm's tumor

Gene product: transcription factor & may be involved w/ p53 signaling
Term
WT1
Definition
TUMOR SUPPRESSOR GENE
Location: 11p

Associated tumor: Wilm's tumor

Gene product: transcription factor & may be involved w/ p53 signaling
Term
NF1
Definition
TUMOR SUPPRESSOR GENE
Location: 17q

Associated tumor: Neurofibromatosis 1

Gene product:
Term
NF2
Definition
TUMOR SUPPRESSOR GENE
Location: 22q

Associated tumor: neurofibromatosis 2

Gene product:
Term
SMAD4
Definition
TUMOR SUPPRESSOR GENE
Location: 18q

Associated tumor: Pancreatic cancer

Gene product: AKA DPC ("deleted in pancreatic cancer")
Term
DCC
Definition
TUMOR SUPPRESSOR GENE
Location: 18q

Associated tumor: Colon cancer

Gene product: DCC= "Deleted in colon cancer"
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