Term
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Definition
| G protein coupled metabotropic receptors that inhibit adenylate cyclase; increased potassium efflux or reduced calcium influx and inhibition of neuronal firing |
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Term
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Definition
| Morphine, meperidine, methadone, fentanyl, heroin, oxycodone |
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Term
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Definition
| Codeine, hydrocodone, propoxyphene |
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Term
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Definition
| Mu receptors and variable affinity for other subtypes; analgesic/euphoric effect; Respiratory depression due to decreased sensitivity to CO2 but medullary respiratory neurons; Cough reflex dampened; Miosis due to effects at EW nucleus leading to increased parasympathetic tone |
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Term
| Pharmacokinetics of morphine |
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Definition
| IV/IM; little BBB crossing but does cross placenta |
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Term
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Definition
| Long half life, used on detox protocols for heroin, can be analgesic |
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Term
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Definition
| Mu receptors primarily but also kappa, don't give to those on MAOI |
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Term
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Definition
| Acts like morphine in opiod naive patients and precipitates withdrawal - outpatient treatment of opiod dependence |
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Term
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Definition
| Partial agonist, most commonly abused |
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Term
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Definition
| Include theophylline, theobromine and caffeine |
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Term
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Definition
| Nicotinic cholinergic receptors in the brain - autonomic effects and stimulant effects mediated within the brain; lower doses --> euphoria/alertness; high doses --> respiratory paralysis |
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