Term
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Definition
100% synthetic phenylpiperidine
DOC OUTPATIENT USE
80X potency morphine;Short duration
Rapid recovery w/o accumulation metabolites
LIPOPHYILIC LOLLIPOP
Used in cardiac surgery due to cardiac stability in combo with neuromuscle blockers |
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Term
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Definition
Chemically modified to reduce first pass effect. prodrug, analgesic = Morphine
CYP2D6 POLYMORPHISM ~1/10 means 10% wont relieve pain!! |
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Term
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Definition
100% synthetic phenylpiperidine
80X potency morphine;Short duration
Rapid recovery w/o accumulation metabolites
LIPOPHYILIC LOLLIPOP
Used in cardiac surgery due to cardiac stability in combo with neuromuscle blockers |
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Term
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Definition
Vicodin - semisynthetic from poppy plant with modified first pass effect
Potency ~ hydrocodone >> morphine/codeine |
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Term
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Definition
100% synthetic compound with 1/10 the potency of morphine. Used in LABOR
NO BILIARY SPASM OR MIOSIS
ALSO CAUSES SEIZURES;TREMORS;CONVULSIONS
Avoid MAO inhibitors |
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Term
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Definition
100% synthetic oral agonist that is equipotent to morphine
complex pharmacokinetics means metabolites build up in body
HIGHEST RISK OPIOD |
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Term
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Definition
CNS: analgesic, respiratory depression, anti-tussive, miosis, tolerance, depencance
Periphral: CONSTIPATION, MUSCLE SPASM, analgesic.
Need to titrate (2/3).
Better against continuous dull over sharp stabbing!
Can cause truncal rigidity so combine with neuromuscular blocker surgery.
Depress medullary and pontine centers for breathing frequency as well as CO center
Trigger acute vomiting at low concentration!
CANNOT DEVELOPE TOLERANCE TO CONSTIPATION
Increases smooth muscle tone causing asthma, urinary retention, increased birthing time
INCREASES CNS PRESSURE, decreases bp for pulmonary edema |
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Term
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Definition
Percocet - semisynthetic from poppy plant with modified first pass effect
Potency ~ hydrocodone >> morphine/codeine |
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Term
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Definition
100% synthetic phenylpiperidine
80X potency morphine;Short duration
Rapid recovery w/o accumulation metabolites
LIPOPHYILIC LOLLIPOP
Used in cardiac surgery due to cardiac stability in combo with neuromuscle blockers |
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Term
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Definition
100% synthetic phenylpiperidine
80X potency morphine;Short duration
Rapid recovery w/o accumulation metabolites
LIPOPHYILIC LOLLIPOP
Used in cardiac surgery due to cardiac stability in combo with neuromuscle blockers |
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Term
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Definition
MIXED Moderate mu receptor agonist and NE reuptake inhibitor
stable congener of O-desmethyltramadol |
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Term
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Definition
MIXED 5HT releaser, NE uptake inhibitor, weak mu agonist
MOA for analgesia mu independant
Same CYP2D6 as Codience
TOXICITY = SEIZURES |
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Term
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Definition
IV Opioid Antagonists
SHORTEST 1-4HR |
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Term
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Definition
Oral Opioid Antagonists
-only one administered orally-
LONGEST 24-48HR |
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Term
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Definition
IV Opioid Antagonists
MID~ 10HR |
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Term
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Definition
Morphine, codiene, hydrocodone,oxycodone, dihydrocodiene
MOre phalanthrene arrive COD |
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Term
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Definition
Mepiridine
fentanyl
alfentanyl
sufentanyl
remifentanyl
Me FEAL SURE phenylpiperidines |
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Term
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Definition
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Term
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Definition
Opioid receptor upregulation at nociceptors stimulated by local
inflammation/ injury
Not same degree as stimulatory effect
can shift lethal dose |
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Term
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Definition
Head injury
Hepatic/renal dysfunction
hypothyroid
pregnancy |
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Term
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Definition
So Far: Morphine as a prototype
Central actions (analgesia, respiratory depression,
antitussive, miosis, euphoria, dependence liability)
Peripheral actions (constipation, increased smooth muscle
tone, analgesia)
Acute toxicity (respiratory depression can be life
threatening)
Tolerance and |
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Term
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Definition
Pulmonary Edema
Acetominophen toxicity
polypharmacy
Morphine may trigger mast cell degranulation and make patient itchy--> switch classes |
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