Term
| How do the statin drugs work? |
|
Definition
1. Inhibition of the rate limiting step of of cholesterol synthesis by inhibiting HMG CoA reductase
2. Depletion of intracellular cholesterol increases cholesterol catabolism by increasing the number of surface receptors on the cell |
|
|
Term
| While the statin drugs are effective at lowering cholesterol in almost all types of hyperlipidemia, they're not as effective at lowering Type IIa hypercholesterolemia for what reason? |
|
Definition
| Patients with Type IIa hypercholesterolemia lack the receptor for LDL receptors |
|
|
Term
|
Definition
| It inhibits lipolysis in adipose tissue thus depriving of the liver of necessary ingredients for triacylglycerol synthesis and thus inhibiting VLDL production which depends on LDL (triacylglycerols) |
|
|
Term
| How do fibrate, clofibrate, and gemfibrozil work? |
|
Definition
| they stimulate lipoprotein lipase thereby decreasing triacylglycerol levels |
|
|
Term
| What types of hyperlipidemia are fenofibrate and gemfibrozil effective in treating? |
|
Definition
Type III-dysbetalipoproteinemia in which ILDLs accummulate
Type IV-hypertriglyceridemia (elevated VLDL)
Type V- Familial mixed hyperctrilyceridemia (elevated VLDL and chylomicron) |
|
|
