Term
T/F
a)frequent heart burn is episodes occuring more than 2 days a week
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Definition
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Term
| What are some risk factors for heart burn? |
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Definition
| Diet, lifestyle, medications, certain diseases, obesity and pregnancy |
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Term
| What are common risk factors for dyspepsia? |
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Definition
| caffeine, stress, smoking, medications |
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Term
| What are some nonpharmacologic therapies for tx HB/dyspepsia? |
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Definition
Avoid triggers, eat smaller meals, reduce dietary fat
refrain from eating 3 hrs before bed
foam wedge under torso or bed |
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Term
| What effect do pharmacologic therapies for HB have on other medications? |
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Definition
| may reduce the absorption and activity of medications requiring an acid environment (ketaconazole) |
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Term
Antacids
Onset of action?
Duration of action?
Interactions?
Systemic absorption? |
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Definition
Onset-fast
Duration-short
May chelate with tetracyclines and fluoroquinolones
minimal absorption except for Sodium Bicarb |
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Term
How does Ca Carbonate compare to mag hydroxide as far as onest and duration?
What is the risk with also taking Ca supplements?
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Definition
slower onset but longer duration
may increase risk of kidney stones in ppl with impaired renal function |
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Term
Sodium Bicarbonate
a) what results from systemic absorption
b) Na content?
c) who should avoid?
d) how often administered? |
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Definition
a) may cause alkinization of urine that may alter the activity of other medications eliminated via the kidneys
b) high sodium content, may cause problem in ppl with renal and CVD
c) ppl taking calcium supplements because of possibility of milk-alkali syndrome
d) every 4 hours |
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Term
How does alginic acid work?
Does it neutralize acid? |
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Definition
It doesn't neutralize the acid itself
It reacts with sodium bicarb in saliva and forma viscous layer that floats on the surface of gastric contents and provide a protective barrier |
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Term
What is simethicone used for?
How does it work?
Absorption? |
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Definition
antiflatulent (relieve gas)
reduces surface tension of gas bubbles
not systemically absorbed |
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Term
How do H2RA work?
Onset and Duration of action?
How can it be used to PREVENT heartburn? |
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Definition
inhibit histmaines at the H2 receptor in the parietal cells
Slower onset but longer duration of action(4-10hrs)
Take 30min to 1 hr before a meal |
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Term
a)What is the shortest acting H2RA?
b)Which H2RA has the relatively no interactions?
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Definition
a) Cimetidine
b) Ranitidine |
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Term
Cimetidine
a) has a weak____effect and may cause ______
b) drug interactions?
c) Dosage? |
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Definition
a) anti-androgenic, dec libido, impotence or gynecomastia
b) inhibits many CYP enzymes and may increase the action of certain drugs (warfarin, phenytoin, theophilline, and tricyclic antidepressants) also may inhibit renal tubular secretion of drugs (procainamide)
c) 200 mg 1-2x/day |
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Term
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Definition
| Cimetidine, ranitidine, famotidine, Nizatidine |
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Term
What is the MOA for PPI?
Onest and duration?
Indications? |
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Definition
a) inhibit secretion of H+ into the stomach regardless of the stimuli
b) slow onset(2-3 hrs) long duration of actio
c) treatment of heartburn in pts with 2 or more days /week |
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Term
PPI
a) administration
b) coating?
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Definition
a) once/day 30 mins before the morning meal for 14 day not more than every 4 months
b) coated to protect against gastric acid |
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Term
Omeprazole
a) drug interactions?
b) What is different about Zegerid?
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Definition
a) inhibits CYP2C19, reduces the action of clopidogrel, may increase action of diazepam,phenytoin and warfarin
b) Contains 20mg of omeprazole and 1100mg of Sodium Bicarb for fast onset of action |
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Term
a)How does bismuth subsalicylate work?
b) side effects?
c) interactions?
d) doasge? |
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Definition
a) local action on the stomach mucosa
b) black coloration of stool and tongue
c) reduce absorption of tetracyclines and fluoroquinolones
d) 525-1050mg every hr as needed MAX of 4 or 8 doses/24hrs |
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