Term
|
Definition
|
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Term
|
Definition
| the conversion of Pk to P |
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Term
| The only antigen in the P1 system |
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Definition
|
|
Term
| P antigen is associated with what blood group system |
|
Definition
| Globoside (GLOB) collection |
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Term
| Pk antigen is associated with which blood group system? |
|
Definition
| Globoside (GLOB) collection |
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|
Term
| Luke (LKE) is the antigen of what blood group system? |
|
Definition
| Globoside (GLOB) collection |
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Term
| Patients with this organism may produce anti-I antibodies and experience transient hemolytic episodes: |
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Definition
|
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Term
| Name the antibody associated with Cold Agglutinin Syndrome |
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Definition
|
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Term
| What are the four diseases auto-antibody I is associated with? |
|
Definition
1) Causative autoantibody of secondary cold hemagglutinin disease following infectious mononucleosis
2) Disease of the RE system
3) Myeloid leukemias
4) Alcoholic cirrhosis |
|
|
Term
| What are the antigens of the Diego Blood Group System? |
|
Definition
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|
Term
| Wright antigens belong to what blood group system? |
|
Definition
|
|
Term
| Dia belongs to what group system? |
|
Definition
|
|
Term
| Dib belongs to what group system? |
|
Definition
|
|
Term
| Wra belongs to what group system? |
|
Definition
|
|
Term
| Wrb belongs to what group system? |
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Definition
|
|
Term
| Name the antigens of the Cartwright Blood Group System |
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Definition
|
|
Term
| Yta is an antigen of what blood group system? |
|
Definition
|
|
Term
| Ytb is an antigen of what blood group system? |
|
Definition
|
|
Term
| The antigen of the Sex-linked Blood Group System is: |
|
Definition
|
|
Term
| What are the antigens associated with the Scianna Blood Group System? |
|
Definition
|
|
Term
| What are the antigens of the Dombrock Blood Group System? |
|
Definition
| Doa, Dob, Gya, Hy, and Joa |
|
|
Term
| Sc3 is an antigen of what blood group system? |
|
Definition
|
|
Term
| Gya is an antigen found in what blood group system? |
|
Definition
|
|
Term
| Sc2 is an antigen found in what blood group system? |
|
Definition
|
|
Term
| Joa is an antigen found in what blood group system? |
|
Definition
|
|
Term
| Sc1 is an antigen found in what blood group system? |
|
Definition
|
|
Term
| Hy is an antigen found in what blood group system? |
|
Definition
|
|
Term
| Doa is an antigen found in what blood group system? |
|
Definition
|
|
Term
| Dob is an antigen found in what blood group system? |
|
Definition
|
|
Term
| What are the antigens of the Colton Blood Group System? |
|
Definition
|
|
Term
| What are the antigens present in the Gerbich blood group system? |
|
Definition
| Ge2, Ge3, Ge4, Webb, Lsa, Ana, and Dha |
|
|
Term
| Name all the antigens that belong to the Cromer blood group system. |
|
Definition
| Cra, Tca, Dr2, Esa, IFC, WESb, UMC, Tcb, Tcc, WESa |
|
|
Term
| Name all of the antigens of the Knops blood group system. |
|
Definition
| Kna, Knb, McCa (McCoy), Sla, Yka (York), and McCb |
|
|
Term
| Sda belong to what blood group system? |
|
Definition
|
|
Term
| Co3 belong to what blood group system? |
|
Definition
|
|
Term
| Webb belongs to what blood group system? |
|
Definition
|
|
Term
| Cra belongs to what blood group system? |
|
Definition
|
|
Term
| Tca belongs to what blood group system? |
|
Definition
|
|
Term
| Dr2 belongs to what blood group system? |
|
Definition
|
|
Term
| Esa belongs to what blood group system? |
|
Definition
|
|
Term
| IFC belongs to what blood group system? |
|
Definition
|
|
Term
| WESb belongs to what blood group system? |
|
Definition
|
|
Term
| UMC belongs to what blood group system? |
|
Definition
|
|
Term
| Tcb belongs to what blood group system? |
|
Definition
|
|
Term
| Tcc belongs to what blood group system? |
|
Definition
|
|
Term
| WESa belongs to what blood group system? |
|
Definition
|
|
Term
| Ge2 belongs to what blood group system? |
|
Definition
|
|
Term
| Ge3 belongs to what blood group system? |
|
Definition
|
|
Term
| Ge4 belongs to what blood group system? |
|
Definition
|
|
Term
| Lsa belongs to what blood group system? |
|
Definition
|
|
Term
| Ana belongs to what blood group system? |
|
Definition
|
|
Term
| Dha belongs to what blood group system? |
|
Definition
|
|
Term
| Coa belongs to what blood group system? |
|
Definition
|
|
Term
| Cob belongs to what blood group system? |
|
Definition
|
|
Term
| McCb belongs to what blood group system? |
|
Definition
|
|
Term
| McCa belongs to what blood group system? |
|
Definition
|
|
Term
| Yka belongs to what blood group system? |
|
Definition
|
|
Term
| Sla belongs to what blood group system? |
|
Definition
|
|
Term
| Kna and Knb belong to what blood group system? |
|
Definition
|
|
Term
| HLA Complex is located on what chromosome? |
|
Definition
|
|
Term
| Class I HLA Complex Genes are |
|
Definition
|
|
Term
| Class II HLA Complex genes include |
|
Definition
| HLA-DR, HLA-DQ, and HLA-DP |
|
|
Term
|
Definition
| certain alleles occur together in the same haplotype more often than would be expected by chance |
|
|
Term
| Class I HLA Molecules are found where? |
|
Definition
| all nucleated cells with few exceptions and platelets |
|
|
Term
| Name the cells one can find Class II HLA molecules |
|
Definition
| B cells, macrophages, monocytes, endothelial cells, and activated T cells |
|
|
Term
| Blood groups associated with Class III HLA molecules |
|
Definition
|
|
Term
|
Definition
| one epitope on a single gene product |
|
|
Term
|
Definition
| Antigens originally classified as a single entity that have been "split" into individual specificities that are serologically distinct |
|
|
Term
|
Definition
| epitopes common to more than one gene product |
|
|
Term
|
Definition
| detect a single HLA gene product |
|
|
Term
|
Definition
| bind to epitopes shared by more than one HLA Ag |
|
|
Term
| The Lewis gene codes for: |
|
Definition
| L-fucosyltransferase, which adds L-fucose to the type 1 precursor structure at the subterminal N-acetylglucosamine (forming the Lea soluble antigen) |
|
|
Term
| What is the RBC Phenotype interpretation of an individual with the following genotype: LeLe, sese, H? |
|
Definition
|
|
Term
| What is the most likely RBC Phenotype interpretation of an individual with the following genotype: LeLe, SeSe, H? |
|
Definition
|
|
Term
| Name the complement component that carries the blood group antigens Chido and Rodgers |
|
Definition
|
|
Term
| What three things can cause a rise in the levels of soluble HLA Class I and Class II antigens? |
|
Definition
1) Infection
2) Inflammatory disease
3) Tranplant rejection |
|
|
Term
|
Definition
| One antibody reacts with different antigens that share epitopes |
|
|
Term
| Crossreactive groups (CREGS) |
|
Definition
| collective term for group of antigens that exhibit crossreactivity in common |
|
|
Term
| HLA System Primary Function |
|
Definition
Primary function is immune response by: 1) contributing to recognition of non-self and 2) coordination of cellular and humoral immunity
|
|
|
Term
| Cross-reactive antibodies |
|
Definition
| antibodies that bind to structurally similar HLA epitopes |
|
|
Term
| What are the HLA Disease Associations with B8 and DR3 |
|
Definition
Juvenile diabetes mellitus
Celiac disease
SLE
Dermatitis herpetiformis |
|
|
Term
| What is the HLA Disease Associations with B8, DR3, B35? |
|
Definition
|
|
Term
| What are the HLA Disease Associations with B27? |
|
Definition
Ankylosing spondylitis
Reiter's disease |
|
|
Term
| What are the HLA Disease Associations with B27 and DR4? |
|
Definition
|
|
Term
| What are the HLA Disease Associations with B27 and DR5? |
|
Definition
| Juvenile rheumatoid arthritis |
|
|
Term
|
Definition
| platelets fail to increase recipient's platelet count |
|
|
Term
| possible causes of platelet refractoriness |
|
Definition
| sepsis, high fever, disseminated intravascular coagulopathy, medications, hyperplenism, and HLA alloimmunization |
|
|
Term
| Explain the cause of TRALI |
|
Definition
Presence of HLA Ab in donor blood react and fix complement on recipient granulocytes.
This causes capillary leakage and pulmonary edema |
|
|
Term
| Transfusion Associated Graft-vs-Host Disease depends on what three factors? |
|
Definition
1) Immune status of recipient
2) Number and viability of lymphocytes in the transfused component
3) Degree of HLA similarity between donor and recipient |
|
|
Term
| When evaluating the quality control of reagents used in blood banking, what four things do you look for? |
|
Definition
1) Reagent Expiration Date
2) Hemolysis in Reagent Cells
3) Turbidity in the Reagents
4) Actual Test Reactions |
|
|
Term
| What type of individuals produce the Anti-PP1Pk? |
|
Definition
|
|
Term
| Auto anti-P is also known as: |
|
Definition
| Donath-Landsteiner antibdoy |
|
|
Term
| Auto anti-P is associated with what disease |
|
Definition
| paroxysmal cold hemoglobinuria |
|
|
Term
| What soluble substances can be found in the gydatid cyst fluid of Echinococcus granulosus tapeworms and turtledove egg ovomucoid? |
|
Definition
|
|
Term
| What antigen is a receptor for parvovirus B19? |
|
Definition
P antigen
This would be associated with erythema infectiosum (Fifth disease) |
|
|
Term
| MNS system is coded for on what chromosome? |
|
Definition
|
|
Term
| What are the MNS system chromosome genes? |
|
Definition
|
|
Term
| The silent gene, Ena fails to produce: |
|
Definition
|
|
Term
| The silent gene Su fails to produce: |
|
Definition
|
|
Term
| The silent gene, Mk fails to produce: |
|
Definition
| Neither Glycophorin A or Glycophorin B |
|
|
Term
| Name the high frequency antigen present when S or s is inherited |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| The clinical conditions that can result in in vivo coating of RBCs with antibody or complement and can be detected by DAT are: |
|
Definition
Hemolytic disease of the fetus and newborn
Hemolytic transfusion reaction
Autoimmune hemolytic anemia
Drug-induced hemolytic anemia |
|
|
Term
| The purpose of check cells is: |
|
Definition
| By adding Ab-coated RBCs to negative reactions, you check for neutralization of antisera by free globulin molecules |
|
|
Term
| The purpose of the minimum of three or four saline washes is: |
|
Definition
| to remove free globulin molecules |
|
|
Term
| What are the four applications and their corresponding tests for the Indirect Antiglobulin Test? |
|
Definition
1) Ab detection: Compatibility testing and Ab screen
2) Ab identification: Ab panel
3) Ab titration: Rh Ab titer
4) RBC phenotype: RBC Ag detection (e.g. weak D, etc.) |
|
|
Term
| Four blood groups that demonstrate dosage effect |
|
Definition
| Rh, Duffy, Kidd, and MNSs |
|
|
Term
| True or False Individuals that are Le(a-B+) do not make anti-Lea Ab |
|
Definition
True
Unconverted Lea is present in saliva and plasma |
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|
