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overdose treatment and drug reactions
usmle review
67
Medical
Graduate
06/01/2009

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Term
acetominophen
Definition
n-acetylcystine
Term
salicylates
Definition
alkalize urne with naHCO3
Term
amphetamines
Definition
acidify urine with nh4cl (ammonium chloride)
Term
anticholinesterase
Definition
atropine, parlidoxime (regenerates ache)
Term
antimuscarinic, anticholinergic agents
Definition
physostigmine salicylate (inhibits ache)
Term
Beta blockers
Definition
glucagon
Term
digitalis
Definition
stop dig. normalize k, lidocaine, anti-dig fragments and mg2
Term
iron poisoing symptoms and treatment
Definition
one of the leading causes of toxicologic fatalities in children. mechanism: cell death from peroxidation of membrane lipids. acute: gastric bleeding. chronic: metabolic acidisois. scarring and gi obstruction. treatment: deferoxamine (chelator)
Term
lead, poisoning symptoms and treatment
Definition
led lines on gingvae (brutons lines) and on ephyses on long bones on x ray. encephalopathy and erythrocyte basophilic stippling. abdominal colic and sideroblastic amenmia. drops: wrist and foot drop. dimercaparol and edta 1st lines of treatment. succmer for kids. caEDTA, dimercaprol, succimer, penicillamine
Term
succimer
Definition
lead poisoning for kids!
Term
mercury arsenic gold
Definition
dimercaprol (BAL), succimer
Term
penicillimine
Definition
copper arsenic gold
Term
cyanide
Definition
step 1 nitrate or hydroxyocoablamin. this converts fe2 to fe3 which has greater affinity for cn, then give thiosulfate to get it out of hte system
Term
methmoglobin
Definition
convert with methyline blue or vit c
Term
carbon monoxide poisoning
Definition
100% o2 and hyperbaric oxygen tank
Term
methanol/ethylene glycol (antifreeze) 3 things
Definition
ethanol, dyalsis, fomepizole
Term
opiods
Definition
naloxone, naltrexone (antagonize opoiod receptors)
Term
benzodiazapines
Definition
flumazenil
Term
TCA
Definition
naHCo3 (acids)
Term
heparin
Definition
protamine
Term
warfarin
Definition
vitamin K + fresh frozen plasma for more immediate relief.
Term
tPA, streptokinase
Definition
aminocaproic acid
Term
atropine like side effects
Definition
tri-cyclics
Term
coronary vasospasm
Definition
cocaine
Term
cutaneous flushing (4)
Definition
niacin, calcium channel blockers, adenosine, vancomycin
Term
dilated cardiomyopathy (2)
Definition
doxorubicin, daunorubicin
Term
torsades de pointes
Definition
class III anti arthymics class a (quinidine) cisapride
Term
colazapine side effect
Definition
atypical antipsychotic causes agranulocytosis
Term
carbamazepine side effect
Definition
agranulocytosis anti convulsant mood stabilizer/ trigeminal neuralgia
Term
colchine side effect
Definition
agranulocytosis
Term
propylthiouracil side effect(s)
Definition
agranulcoytosis, aplastic anemia
Term
methimazole side effct(s)
Definition
aplastic aemia and agranulocytosis
Term
chloroamphenicol
Definition
aplastic anemia
Term
benzene
Definition
aplastic anemia
Term
nsaids
Definition
gastritis/ulcers/aplastic anemia
Term
direct coombs positive hemolytic anemia
Definition
methyldopa
Term
gray baby syndrome
Definition
chloramphenicol
Term
hemolosys in g6pd
Definition
is pain isonialzid, sulfonamides, primaquine, asprin, ibuprofen, nitrofuraoin
Term
megaloblastic enemia
Definition
phenytoin, methotrexate, sulfa drugs
Term
thrombotic complications
Definition
oral contraceptives
Term
cough
Definition
ace inhibiters not ARBS (losartan) due to persistance of bradykinin ace digests it
Term
pulmonary fibrosis
Definition
amidarone, bleomycin buslfarin
Term
acute cholestatic hepatitis
Definition
macrolides yikes
Term
focal to massive hepatic necrosis (5)
Definition
halothane, valproic acid, acetopmenaphen, amanita phalloides
Term
hepatitis
Definition
inh, smallare amount is rifampin
Term
pseudomembranous colitis
Definition
clindamycin/ ampicillin
Term
adrenocortico insuiciency
Definition
glucocoroticoid withdrawl/ ketokonazole
Term
gynecomastea (4)
Definition
some drugs create awesome knockers. spirolactone. digitalis, cimetidine alcohol abuse, ketoconazole
Term
hot flashes (2)
Definition
tomoxifen, clomiphene
Term
gingival hyperplasia
Definition
phenytoin
Term
gout (2)
Definition
furosemide thiazides
Term
osteoporosis (2)
Definition
corticosteroids and heparin
Term
photosenstivity
Definition
Sulfonamides, amidoarone, tetracycline (metronidazole)
Term
stevens johnson sndrome 8 (focus on classes)
Definition
ethosuximide, lamotrigine, carbamazpine, phenobarbital, phenytoin, sulfa drugs, peniccilin, allopurinol
Term
SLE like syndrome (4)
Definition
hydralazine, INH, procainamide, phenytoin HIPP
Term
tendonitis/ caritlage dmage
Definition
flouroquinolones e.g. cipiro
Term
fanconi's syndrome
Definition
expired tetracycline. less proximal tube reabsortion of amino acids, glucose, phosphate, uric acid, protein and electorlytes. causes include wilsons diesease and glycogen storage diseases e.g. cisplatin and expired tetracycline. less phosphate (rickets/osteomalacia) less hco3 reabsortion acidosis. less na resbsortion- more distal reabsoritona nd hypokalemia
Term
interstitial nephritis (3)
Definition
methicillin, nsaids, furosemide
Term
hemorrhagic cystitis
Definition
cyclophsophamide, isoamide
Term
chinchonism
Definition
blurred vision, ringing ears, quinidne quinine
Term
di
Definition
lithium democlocyline
Term
parkinsons like syndrome
Definition
mostly antipsychotics that block dopamine makes sense. haloperidol, chlorpromazine, reserpine, metclpramide
Term
seizures
Definition
buprion, imipenem cisltain, isoniazid
Term
tarditive dyskinesia
Definition
mostly typical antipsychotics but maybe a bit in atypical
Term
disulfiram like reaction
Definition
metronidazole, certain cephalosproines, procabazine, 1st generation sulfonlurea
Term
nephrotoxicity/neuro
Definition
polymixins
Term
nephrotoxicity/ototoxixity
Definition
aminoglycosides, vancomycin, loop diruetics, cisplatin
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