Term
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Definition
| found in the secretory granules of mast cells- extracted for porcine intestina mucosa |
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Term
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Definition
| enhances activity of antithrombin, no intrinsic activity, binds antithrombin III and catalyzes inactivation of thrombin and factor Xa in a 1:1 ratio |
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Term
| neutralizes heparin by forming an inactive protamine-heparin complex |
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Definition
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Term
| Used when low clinical probability of DVT or PE assessed; high negative predictive value |
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Definition
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Term
| used with large doses of heparin exceeding plasma concentrations of > 1 unit/ml |
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Definition
| activated clotting time (ACT) |
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Term
| used to establish therapeutic aPTT's in institutions or in patients with unreliable aPTTs |
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Definition
| Plasma heparin concentrations |
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Term
| unfractionated heparin AEs |
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Definition
| hemorrhage, osteoporosis, hyperkalemia, hypersensitivity reactions, thrombocytopenia |
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Term
| occurs 5-14 days after initiation of heparin; decrease from baseline by at least 50%, very low platelet counts (<15,000) rare |
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Definition
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Term
| differs from other hirudins: small synthetic molecule derived from arginine |
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Definition
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Term
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Definition
| binds only to activate catalytic siste of thrombin; ability to inhibit clot boundd thrombin, eliminated by hydroxylated and aromatization in liver to inactive metabolites |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| DVT prophylaxis in pts undergoing surgery for hip replacement; does not have an indication for the txt of HIT |
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Definition
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Term
| synthetic active pentasaccharide |
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Definition
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Term
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Definition
| specific pentasaccharide units bind specifically but reversibly to ATIII and selectively inactivates factor Xa |
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Term
| surface receptor for von Willebrand factor and fibrinogen |
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Definition
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Term
| thrombin and collagen are platelet agonists |
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Definition
| activate GPIIb/IIIa receptors |
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Term
| allows bridging to adjacent platelets |
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Definition
| receptor/fibrinogen complex |
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Term
| chimeric monoclonal antibody (Fab); Irreversibly binds to GPIIb/IIIa receptor |
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Definition
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Term
| cyclic peptide inhibitor of fibrinogen binding sites of GPIIb/IIIa |
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Definition
| Eptifibatide (Integrillin) |
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Term
| Tyrosine derivative (non-peptide) inhibitor of GPIIb/IIIa |
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Definition
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