Term
| Antipsychotics (Haloperidol), reserpine at high doses, and MPTP (by-product of illicit meperidine analog) and is irreversible |
|
Definition
| Drug induced Parkinsonism |
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Term
| Agent used in drug therapy of Parkinson's instead of Dopamine which has low bioavailability and does not cross BBB |
|
Definition
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Term
| This is combined with L-dopa, inhibits DOPA decarboxylase (active only peripherally) which allows lower effective doses of L-dopa and allows for fewer SE's (GI distress, postural hypotension, and dyskinesias) |
|
Definition
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Term
| Clinical response that may fluctuate in tx of Parkinson's dx |
|
Definition
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|
Term
| Anti-Parkinson's drug which increases intraocular pressure and is contraindicated in closed angle glaucoma |
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Definition
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|
Term
| Ergot alkaloid that is a partial agonist at D2 receptors in the brain, used for patients who are refractory or cannot tolerate levodopa, causes erythromelalgia |
|
Definition
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|
Term
| Non ergot agents used as first-line therapy in the initial management of Parkinson's |
|
Definition
| Pramipexole and ropinirole |
|
|
Term
| Enhances dopaminergic neurotransmission. SE's include CNS excitation, acute toxic psychosis and livedo reticularis |
|
Definition
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Term
| Inhibitor of MAO type B which metabolizes dopamine, used adjunct to levodopa or as sole agent in newly diagnosed pts |
|
Definition
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|
Term
| Inhibitors of catechol-O-methyltransferase (COMT), used as adjuncts in Parkinson's dx and cause acute hepatic failure (monitor LFT's) |
|
Definition
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|
Term
| COMT inhibitor that does not cause liver problems; used with levodopa and carbidopa as part of Stalevo |
|
Definition
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|
Term
| Agent decreases the excitatory actions of cholinergic neurons. May improve tremor and rigidity but have LITTLE effect on bradykinesia. Atropine-like SEs |
|
Definition
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|
Term
| Agent effective in physiologic and essential tremor |
|
Definition
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|
Term
| Agents used in Huntington's Disease |
|
Definition
| Tetrabenazine (amine depleting drug), Haloperidol (antipsychotic) |
|
|
Term
| Agents used in Tourette's dx |
|
Definition
|
|
Term
| Chelating agent used in Wilson's disease |
|
Definition
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|
Term
| Dopamine agonist used for 'off' periods of akinesia |
|
Definition
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