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Pathological Diseases
Stuff you need to know
60
Pathology
Professional
01/08/2013

Additional Pathology Flashcards

 


 

Cards

Term
Behcet Syndrome
Definition
HLAB-51/B27, immune complex vasculitis, recurrent apthous ulcers, uveitis, and genital ulcers

TX: NSAIDS, Steriods, Colchicine, Thalidomide
Term
Peutz-Jegher Syndrome
Definition
Melanin pigmentation of buccal membrane with colonic polyps btw 5-10 y/o
Term
Addison's Disease
Definition
Increased ACTH leads to hyperpigmentation in buccal mucosa
Term
Lead poisoning
Definition
Lines along gingiva in adults with gingivitis
Term
Congenitall erythropoietic porphyria
Definition
deposits in teeth that impart a reddish brown color
Term
Pellagra
Definition
Niacin deficiency
Term
Leukoplakia/Erythroplakia
Definition
lesions in oral mucosa that fail to wipe off
Term
Ameloblastoma
Definition
radiolucent bone with soap bubble appearance but does not metastasize comes from dentigerous cyst or enamal organ epithelium
Term
Squamous cell carcinoma
Definition
most common site is lower lip
most common malignancy in oral mucosa
metastasizes to superior jugular node
Term
Basal cell carcinoma
Definition
most common site is upper lip, association with UV exposure
Term
Pleomorphic adenoma
Definition
found in parotid gland (usually benign) painless moveable mass, involvement of the facial nerve is a sign of malignancy
Term
Warthin Tumor
Definition
salivary gland tissue located in lymph node
Term
Warthin Tumor
Definition
salivary gland tissue located in lymph node
Term
Mucoepidermoid carcinoma
Definition
most common malignant salivary gland tumor of parotid
Term
Tracheoesophageal fistula
Definition
lower esophagus connects with trachea, polyhydramnios, abdominal distention, food regurgitates
Term
VATER disease
Definition
vertebral abnormalities, anal atresia, TE fistula, renal disease and absent radius
Term
Plummer Vinson Syndrome
Definition
iron deficiency, esophageal webs, glossitis, leukoplakia
Term
Zenkers diverticulum
Definition
outpouching in proximal esophagus due to weakness in cricopharyngeus muscle
Term
Boerhaave Syndrome
Definition
rupture of distal esophagus due to endoscopy (75%) or vomiting, leads to air in mediastinum with crunching sound on auscultation
Term
Achalasisa
Definition
bird beak sign on barium swallow, lack of LES relaxation, loss of smooth muscle contraction , loss of NO causes lack or relaxation
Term
Leiomyoma
Definition
most common esophageal benign tumor
Term
Congenital pyloric stenosis
Definition
projectile vomiting lacking bile, olive on palpation, visibile hyperperistalsis


not present at birth but is aquired over 3 weeks is hypertrophy of circular muscles in pyloric sphincter with NO deficency
Term
Gastroparesis
Definition
vomiting of undigested food hours after eating, can signify a diabetic neuropathy of autonomic (vagus origin)
Term
Curling syndrome
Definition
hemorrhagic gastritis due to burns
Term
Cushing syndrome
Definition
hemmorhagic gastritis due to head injury
Term
Melana
Definition
dark tar colored stool due to blood loss into lumen above the duodenal jejunal junction
Term
Type A chronic gastritis
Definition
due to pernicious anemia, involves fundus and body with increased risk for adenocarcinooma
Term
Type B chronic gastrisits
Definition
Due to helicobacter pyylori (gram -, curved rod) noninvasive and urease +
Term
Menetrier disease
Definition
enlarged rugae folds producing protein losing enteropathy with edema atrophy of parietal cells
Term
Duodenal Ulcer
Definition
releaved by eating, increased basal acid and maximum acid production, bleeding from gastroduodenal artery) risk increased in MEN I syndrome
Term
gastric ulcer
Definition
pain worsens after eating, bleeding from left gastric artery, located on lesser curve of stomach, must be biopsied because of chance of malignancy
Term
ZE syndrome
Definition
Pancreatic islet cell tumor that secretes excess gastrin, association with MEN I, multiple ulcers, resistant to therapy, distal to duodenum,
Term
Diffuse gastric cancer
Definition
Signlet ring cells, linitis plastica, krukenberg tumor of ovaries with singlet ring cell metastasis
Term
Norwalk virus
Definition
#1 adult gastroenteritis, fecal oral spread
Term
CMV
Definition
diarrhea in aids with CD4 between 50-100
Term
Rotavirus
Definition
#1 diarrhea in children , secretory diarrhea, tx: hydration and nitazoxamide
Term
Bacillus Cereus
Definition
gram + rod, food poising, rice or tacos
Term
Campylobacter jejuni
Definition
Curved gram - rod, water, chicken, milk, Bloody diarrhea with crypt abcesses fever, abd pain,

Guillain Barre syndrome and HUS, HLA-B27 spondyloarthropathy

TX: erythromycin
Term
C. botulinum
Definition
Gram + rod block ACH release from presynapse, pupuliary dilation

Floppy baby with honey injestion, constipation
Term
C. Diff
Definition
Gram + rod, Pseudomembranous colitis due to clindamycin and 3rd gen cephalosporins ,A/B Toxin,
TX: metronidazole
Term
Celiac's
Definition
HLA DRQ2/8, dermatitis herpetiformis, anti-tTG IgA, Anti-endomysial, Antiglaiadin IgA/IIgG, AI against gluten
Term
Small bowel adhesion
Definition
most common cause of small bowel obstruction
Term
Dudodenal atresia
Definition
double bubble sign on xray
Term
angiodysplasia
Definition
dilation of mucosal and submucosal veins in cecum and right colon leading to complete blood loss and is associated with VwF disease and calcific aortic stenois
Term
Sigmoid diverticulosis
Definition
most common cause of hematochezia
Term
Primary Adenocarcinoma
Definition
duodenum most likey place
Term
vermiform appendix
Definition
most common sight for carcinoid tumor
Term
Carcinoid Syndrome
Definition
tumor secretes serotonin into systemic circulation leading you facial telangiectasis, bronchospasm induced dyspnia, flushing of skin, diarrhea, and TRICUSPID REGURG and PULM STENOIS due to serotonin increasing the collagen production in these valves
Term
Turcot syndrome
Definition
AR polyposis plus brain cancer (astrocytoma and medullablastoma)
Term
FAP
Definition
AD APC mutation leading to 100's polyps all leading to cancer of the colon, hyperplastic retinal pigmentation,
Term
Gardner Syndrome
Definition
AD colong cancer plus benign osteomas of the jaw and desmoid tumors
Term
Adenoma Carcinoma sequence
Definition
mutation of APC-->RAS-->TP53
Term
HNPCC
Definition
MSH1/MSH2 AD mutation leading to DNA mismatch gene mutation
Term
Left colon cancer
Definition
tends to be obstructive (apple core lesions) with napkin ring apperance
Strep bovis endocarditis
Term
Right side colon cancer
Definition
tends to bleed , more likely for iron deficency
Term
Serum carcinoembryonic antigen
Definition
used to screen for colon cancer recurrences
Term
C fibers in appendicitis
Definition
refer pain to the midline due to visceral peritoneal irritation which are unmyelnatied
Term
Ao' fibers in appendicitis
Definition
irritation of parietal peritoneum will localize to McBurney's point (unless malrotated)
Term
Subphrenic abcesses
Definition
Postoperative persistant fever, fixed right diaphram with right side peural effusion, tenderness over left 7/8 ribs
Term
Pyelophlebitis
Definition
inflammation of portal vein
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