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Pathology Board Review
Pathology Tests 1 - 4
217
Medical
Graduate
12/20/2011

Additional Medical Flashcards

 


 

Cards

Term
What is another name for Arthrogryposis
Definition
Arthrogryposis Multiplex Congenita
Term
Name this Medical Condition?


• Congenital (Present at birth)
• Characterized by multiple joint contractures
• Can include muscle weakness
• Non progressive
• Articular rigidity
• Three Types
Definition
Arthrogryposis, also known as Arthrogryposis Multiplex Congenita
Term
What is brittle bone disease known as?
Definition
Osteogenesis imperfecta or OI
Term
Name this Medical Condition?

• X-ray will show wormian bones
• Deficiency of type 1 collagen
• Four types (1 and 4 ) live (2 and 3) Don’t
• Triangular Face
Definition
Osteogenesis imperfecta
Term
Name this Medical Condition?

A neuromuscular disease characterized by degeneration of motor neurons, resulting in progressive muscular atrophy (wasting away) and weakness.
Definition
Spinal Muscular Atrophy (SMA)
Term
Name this Medical Condition?


• Anterior Horn Cell Degeneration
• Progressive Muscle wasting
• Neuromuscular Dz
Definition
Spinal Muscular Atrophy (SMA)
Term
Name this Medical Condition?

paralysis of the arm caused by injury to the upper group of the arm's main nerves, specifically the upper trunk C5-C6 is severed
Definition
Erb's palsy (Erb-Duchenne Palsy)
Term
Name this Medical Condition?

• Trauma at birth or breach delivery
• Stretching or damage of Brachial Plexus
• C5 – C6
• Traction Injury
• Waiters Tip Position
Definition
Erb's palsy (Erb-Duchenne Palsy)
Term
Name this Medical Condition?

a variety of partial palsy of the lower roots of the brachial plexus. Paralysis of small muscles of the wrist
Definition
Klumpke's paralysis
Term
Name this Medical Condition?


• Claw Hand
• Ulna Nerve
• Good Proximal Control but not Distal
• Poor Sensation
Definition
Klumpke's paralysis
Term
Name this Medical Condition?

A stiff neck associated with muscle spasm, classically causing lateral flexion contracture of the cervical spine musculature (a condition in which the head is tilted to one side).
Definition
Torticollis, or wryneck
Term
Name this Medical Condition?

• Congenital (Present at Birth)
• Twisted Neck
• Involves the SCM
• Develops in utero (cramped)
• Firm non tender enlargement nodule on SCM
Definition
Torticollis, or wryneck
Term
Name this Medical Condition?

A severe recessive X-linked form of muscular dystrophy characterized by rapid progression of muscle degeneration, eventually leading to loss of ambulation and death.
Definition
Duchenne muscular dystrophy (DMD)
Term
Name this Medical Condition?


• Genetic
• X Linked (male gender)
• Recessive

• Genetic
• X Linked (male gender)
• Recessive
• Muscle Cells get replaced with fat
Definition
Duchenne muscular dystrophy (DMD)
Term
Name this Medical Condition?

• Gowers Sign – walking of hands up legs to stand up
• Positive trendelaenberg gate then a waddle gate
• Toe walkers
• Contractures of planter flexors
• Progressive weakness starts distally starting with legs
• Pseudo Hypertrophy of calves
• IQ just below the average
• All muscles get weaker
• Death by 3rd decade
Definition
Duchenne muscular dystrophy (DMD)
Term
Name This Group of Disorders?

Refers to a group of hereditary muscle diseases that weaken the muscles that move the human body. Characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.
Definition
Muscular dystrophy
Term
Name This Group of Disorders?


• Inherited
• Progressive (as you age it will get worse)
• Genetic
• Symmetrical muscle wasting
• Six major types
Definition
Muscular dystrophy
Term
Name this Medical Condition?


• More often seen in females
• Three forms
• Can be manually displaced
• Breach Delivery
• Hip Dislocation during birth
• Gravity due to lax ligaments (cultural)
• Longer dislocated in utero more problems develop
• Unilateral problem – Trandelenberg gate
Definition
Hip dysplasia
Term
Name this Medical Condition?

A congenital or acquired deformation or misalignment of the hip joint.
Definition
Hip dysplasia:
Developmental dysplasia of the hip (DDH)[1] or congenital dysplasia of the hip (CDH)
Term
Name this Medical Condition?

Part of some of the vertebrae are not completely closed. The split in the vertebrae is so small that the spinal cord does not protrude. The skin at the site of the lesion may be normal, or it may have some hair growing from it; there may be a dimple in the skin
Definition
Spina bifida occulta
Term
What does occulta mean?
Definition
Hidden
Term
Name this Medical Condition?


• Hidden (but with visible signs)
• Tuft of hair at spot
• Usually no deficits
• Could have mild bladder problem
• Possible Foot weakness
Definition
Spina bifida occulta:
Term
What does Aperta mean?
Definition
Open
Term
Name this Medical Condition?

The vertebrae develop normally, however the meninges are forced into the gaps between the vertebrae. As the nervous system remains undamaged,
Definition
Meningocele: (aperta – Open)
Term
Name this Medical Condition?


• Herniation
• Avoid laying baby on back pre surgery
• Spinal cord remains intact
• Protrusion of the meninges and CSF
• Pouch / Sac
• No neuro damage or very mild defects
• Might have bladder problems as well
• Possible foot weakness
Definition
Meningocele: (aperta – Open)
Term
Name this Medical Condition?

A serious and common form, the unfused portion of the spinal column allows the spinal cord to protrude through an opening. The meningeal membranes that cover the spinal cord form a sac enclosing the spinal elements.
Definition
Myelomeningocele:
Term
Name this Medical Condition?

• Includes Spinal Cord
• 75% occur at L5 – S1
• Will be neuro damage and neuro defect
• Bowl and Bladder incontinence
• Can have scoliosis
• Almost all have hydrocephalus
• Arnold Chairi malformation
• Most have normal intelligence
• Tethered Cord (cord gets bound down as child grows)
Definition
Myelomeningocele:
Term
Name this Medical Condition?

• Lidianna Griffin
• Ventricles enlarge
• Increase CSF in the ventricles
• Brain and blood tissues compressed
• Infants head enlarged
• Shunts used to manage extra fluid
• Defect in brain stem blocking CSF (Arnold Chari)
• Sunset eyes
• Seizers
• Vomiting
• Lethargic
Definition
Hydrocephalus
Term
Name this Medical Condition?

Medical condition in which a person's spine is curved from side to side.
Definition
Scoliosis
Term
How many degrees from normal must a spine be curved to be considered Scoliosis?
Definition
10 degrees
Term
How is Scoliosis defined?
Definition
Defined by the convexity (side of the convex)

R Scoliosis (R is the convex side)
Term
What side the the muscles shorten on a Scoliosis pt?
Definition
• Muscles shorten on the CONCAVE side
Term
Where is the greatest force on the vertebra with a Scoliosis pt?
Definition
At the apex of the Convexity
Term
At what point would you have to have surgery to correct a Scoliosis
Definition
• Surgery greater than 45%
Term
A Scoliosis greater than 60% will cause what?
Definition
• Greater than 60% pulmonary problems
Term
Name this Medical Condition?

• Curve disappears when problem is solved
• Short Term
• Can be fixed
• Caused by pain, poor posture, leg length difference
• Curve disappears when bent forward
• Can become structural
• Resolves as problem is addressed
Definition
Functional Scoliosis (postural)
Term
Name this Medical Condition?


• Fixed curve
• Vertebral rotation
• Congenital
• Idiopathic
• Curve does not disappear when bent over to 90%
• Wedged vertebrae
• Idiopathic
• Gibbus – Rib Hump
• Increase during growth spur
Definition
Structural Scoliosis
Term
Name this Medical Condition?

Also called hunchback, is a common condition of a curvature of the upper back. It can be either the result of degenerative diseases (such as arthritis), developmental problems (the most common example being Scheuermann's disease)
Definition
Kyphosis
Term
Name this Medical Condition?

• Schmorl's nodes (nucleus material protruding from vertebral bodies)
• Sherman’s Disease
• Structural deformity
• Anterior wedging
• Adolescents 12 – 16
• Taller than average children
Definition
Kyphosis
Term
Name this medical condition?

a chromosomal condition caused by the presence of all or part of an extra 21st chromosome.
Definition
Down Syndrome
Term
How many stages are there in tissue healing?
Definition
3 Not including the pre-stage
Term
What stage of tissue healing is this?


• Coagulation
• Blood flow is limited then stops
• Vasoconstriction (Blood Flow Stops)
• Stimulate Homeostasis
• This Stage overlaps acute inflammation
• First 5 mins – 48 hours
Definition
PRE (pre stage) (ACUTE)
Term
What phase of tissue healing is this?


• Vasodilation – increase in blood flow
• Vasodilation – First 5 – 7 days
• White blood cells arrive to clean up debris
• Cytokines – Main type of white blood cell
• Inflammation - Means Reaction
• Pus – pus is the dead white blood cells
Definition
Phase 1 (Reaction Phase)
Term
What are the 4 signs of inflammation?
Definition
• RUBOR – red from vasodilation
• TUMOR – swelling due to increase fluid mobility
• CALOR – Warmth from blood flow
• DALOR - Pain from pressure from the swelling
• Usually only (four) signs of inflammation
• FIFTH – Loss of function (usually only four signs of inflammation)
Term
what is RUBOR?
Definition
• RUBOR – red from vasodilation
Term
What is TUMOR?
Definition
• TUMOR – swelling due to increase fluid mobility
Term
What is CALOR?
Definition
CALOR – Warmth from blood flow
Term
What is DALOR?
Definition
• DALOR - Pain from pressure from the swelling
Term
What phase of tissue healing is this?


• 5 -21 days
• Highly vascular phase
• Key Cell = Fibroblast
• Tissue regenerates from the (bottom up)
• Highly vascular stage
• Granulation – fills would (red like beef… This is not muscle)
• Granulation is mostly capillaries (very vascular)
• Epithelialization 2-3 layer epidermis forms over the granulation bed
• During the repair phase type III immature collagen is produced (not strong)
• Collagen is protein the remodeling occurs during stage 2
• ROM exercise occur in
• Joint function is promoted with Proper Stress
• Stress on Ligament Promotes Injury
• Right amount of stress converts immature collagen to mature collagen with stress
• Pressure promotes healing (on burn patient's pressure prevents scar tissue)
Definition
Phase 2 (Repair)
Term
Phase 2 in tissue healing is also known as the what phase?
Definition
The Repair Phase
Term
What phase of tissue healing is this?

• Starts when repair phase is over
• Between 14 -21 days and continues until healing is complete
• Tissue is gradually changing from mostly cellular to fibrous with more and more organized collagen
• Scar is maturing with only 3% cellular and almost all collagenous
• Type I collagen
• Skin requires 12 – 18 months to form mature fibrous scar
• Keloid Formation = Think bundles of accumulated collagen
Definition
Phase 3 (Remodeling)
Term
Phase 2 in tissue healing is also known as the what phase?
Definition
The Remodeling Phase
Term
What are 4 things that can cause an Ongoing Chronic inflammation
Definition
• Untreatable Bacteria
• Extensive tissue death
• Persistent immune reaction
• Reoccurrence of acute inflammation
Term
What organ system is this?

is the organ system that protects the body from damage, comprising the skin and its appendages (including hair, scales, feathers, and nails). It has a variety of functions; it may serve to waterproof, cushion, and protect the deeper tissues, excrete wastes, and regulate temperature, and is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature. In humans it also provides vitamin D synthesis.
Definition
Integumentary System
Term
What are 7 problems the elderly might have with their skin?
Definition
• Decrease in pain perception
• Decreased Vascularity
• Weakened inflammatory reaction
• Lax skin (lax because its not elastic... will not recoil)
• Decreased thermo regulation
• Fewer and thinner walled blood vessels in dermis (look pale)
• Decreased immune functions
Term
what part of the body is a principle supplier of vitamin D?
Definition
Epidermis
Term
Name this Medical Condition? The skin changes that occur in the leg as a result of blood pooling from insufficient venous return
Definition
Stasis Dermatitis
Term
Name this Medical Condition?


• LE problem from nervous insufficiency (blood can not flow back up to the heart)
• Causes edema, tissue hypoxia, necrosis
• Shallow Ulcers
• Areas of dry skin develop
• Legs Feel Heavy
• Brown Stained Areas (hemosiderin)
• Patient’s with history of DVT or varicose veins are prone
Definition
Stasis Dermatitis
Term
Name this Medical Condition?

a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin.
Definition
Cellulitis
Term
Name this Medical Condition?


• Acute inflammation of the skin and subcutaneous tissue space
• Usually a strep or staff infection (Bacteria)
• Very tender (hurts)
• Low immune system at risk
• Mostly affects extremities
• Swelling and redness
Definition
Cellulitis
Term
Name This Medical Condition?

a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox
Definition
Herpes Zoster – Shingles
Term
Name this Medical Condition?


• Reactivation of chicken pox virus
• Dormant in ganglia of the posterior nerve roots
• Peaks ages 50 – 70
• Patient stress and weakened immune systems bring on HZ
• Unilateral Event (EX: Thoracic Band in very specific area)
• Pain and tingling along dermatome
• Red Papules
• Clear or pus filled vesicles
• Very pain full
• Drugs can control the virus
• Complications = postherpetic neuralgia (chronic pain with HZ)
Definition
Herpes Zoster – Shingles
Term
Name this Medical Condition?

• HAART is treatment
• Looks like a skin disorder
• Cancer of Vascular tissue
• Now prevalent with AIDS or transplant recipients (Epidemic)
• Herpes Virus
• Present in ALL AIDS related patient
• Male Homosexuals
• Commonly on lower extremity (little pink, red, purple, lesions)
• Slowly enlarge and legs become edematous
• Progression with lymph obstruction
• Later can involve entire body
• May be the first indication of AIDS
Definition
Kaposi’s Sarcoma
Term
Name this Medical Condition?

chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas. These lesions develop as a red, inflamed patch with a scaling and crusty appearance. The center areas may appear lighter in color with a rim darker than the normal skin.
Definition
Lupus Erythematous Cutaneous (discoid form)
Term
Name this Medical Condition?

• Chronic skin eruption
• Occurs when skin is exposed to the sun
• Women > Men – Women Late 20’s forward
• Scaring and disfigurement

o Acute
• Classic butterfly rash on face
• Occurs on face
• Raised Red rashes or lesions
• Autoimmune defect
• Linked with genetic factors
• Smoking is a risk factor
• Sun is a risk factor
• Hair Becomes Brittle (Fall Out)
• Skin may change color when lesions go away
• Inflammation of cutaneous blood vessels
Definition
Lupus Erythematous Cutaneous (discoid form)
Term
• Chronic skin eruption
• Occurs when skin is exposed to the sun
• Women > Men – Women Late 20’s forward
• Scaring and disfigurement

o Acute
• Classic butterfly rash on face
• Occurs on face
• Raised Red rashes or lesions
• Autoimmune defect
• Linked with genetic factors
• Smoking is a risk factor
• Sun is a risk factor
• Hair Becomes Brittle (Fall Out)
• Skin may change color when lesions go away
• Inflammation of cutaneous blood vessels
Definition
Lupus Erythematous Cutaneous (discoid form)
Term
• Chronic skin eruption
• Occurs when skin is exposed to the sun
• Women > Men – Women Late 20’s forward
• Scaring and disfigurement

o Acute
• Classic butterfly rash on face
• Occurs on face
• Raised Red rashes or lesions
• Autoimmune defect
• Linked with genetic factors
• Smoking is a risk factor
• Sun is a risk factor
• Hair Becomes Brittle (Fall Out)
• Skin may change color when lesions go away
• Inflammation of cutaneous blood vessels
Definition
Lupus Erythematous Cutaneous (discoid form)
Term
• Chronic skin eruption
• Occurs when skin is exposed to the sun
• Women > Men – Women Late 20’s forward
• Scaring and disfigurement

o Acute
• Classic butterfly rash on face
• Occurs on face
• Raised Red rashes or lesions
• Autoimmune defect
• Linked with genetic factors
• Smoking is a risk factor
• Sun is a risk factor
• Hair Becomes Brittle (Fall Out)
• Skin may change color when lesions go away
• Inflammation of cutaneous blood vessels
Definition
Lupus Erythematous Cutaneous (discoid form)
Term
Name this Medical Condition?

chronic systemic autoimmune disease characterized by fibrosis (or hardening), vascular alterations, and autoantibodies. There are two major forms:
Definition
Scleroderma (systemic sclerosis)
Term
What are the two forms of scleraderma?
Definition
Limited systemic sclerosis/scleroderma:
involves cutaneous manifestations that mainly affect the hands, arms and face. Previously called CREST syndrome in reference to the following complications: Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, and Telangiectasias. Additionally, pulmonary arterial hypertension may occur in up to one third of patients and is the most serious complication for this form of scleroderma

Diffuse systemic sclerosis/scleroderma:
is rapidly progressing and affects a large area of the skin and one or more internal organs, frequently the kidneys, esophagus, heart and lungs. This form of scleroderma can be quite disabling
Term
Name this Medical Condition?

• Edema in fingers and Hands
• Connective tissue disease
• Skin is painful and stiff
• CREST syndrome
• No Cure
• Attack on immune system
• Raynaud’s Phenomenon – White then sudden, blue (cyanosis) and red (erythema) and rewarming fingers and toes – painful
• Triggered by cold or stress
• Women greater than men
Definition
Scleroderma (systemic sclerosis)
Term
Name this medical condition?

Chronic inflammatory myopathy related to dermatomyositis and inclusion body myositis. It means 'many muscle inflammation ad tends to become evident in adulthood, presenting with bilateral proximal muscle weakness often noted in the upper legs due to early fatigue while walking. Sometimes the weakness presents itself as an inability to rise from a seated position without help or an inability to raise one's arms above one's head. The weakness is generally progressive, accompanied by lymphocytic inflammation (mainly cytotoxic T lymphocytes).
Definition
Polymyositis and Dermatomyositis

* Dermatomyositis is polymyositis with a skin rash (DERMA)
Term
Name this Medical Condition?

medical condition where localized damage is caused to skin and other tissues due to extreme cold. It is most likely to happen in body parts farthest from the heart and those with large exposed areas.
Definition
Frost Bite
Term
Name this Medical Condition?


Over exposer to cold and air to local parts
• Systemic Injures – hypothermia
• Ice crystals can form in the tissue
• Interferes with enzyme and metabolic function
• Superficial – skin and subcutaneous tissue
• Deep – beyond subcutaneous tissue
Definition
Frost Bite
Term
What is the rule of 9s?

Fill in the blank:

• head =
• each arm =
• each leg =
• anterior thorax =
• posterior thorax =
Definition
• 9 head
• 9 each arm
• 18 each leg
• 18 anterior thorax
• 18 posterior thorax
Term
What degree burn is this?

• Sunburn
• Epidermis is involved
• Relieved by cold
• Flash burn (quick exposure)
• Desquamation (shedding of skin)
• Will blanch with pressure and release
Definition
1st degree
Term
What degree burn is this?


• Large blister
• Dermis Involved
• Wet weeping broken skin
• Edema with mottled skin
• Partial thickness burn
• Can be superficial or deep
Definition
2nd Degree
Term
What degree burn is this?


• Subcutaneous tissue
• Dry surface with fat exposed
• Tissue disrupted
• No pain until the nerve endings come back
• Pus forms within a few weeks
• Eschar forms and needs to be removed
• Grafting takes place
• <25% of body burned localized response
• Greater > 25% systemic body response (renal, GI, Pulmonary, ext..
Definition
3rd Degree
Term
What stage pressure ulcer is this?

• Skin is intact and does not blanch
Definition
Stage 1 Pressure Ulcer
Term
What stage pressure ulcer is this?

• Skin not intact (breached)
• Partial Thickness (epidermis and Dermis)
• Shallow Abrasions or blister
• Shallow crater
Definition
Stage 2 Pressure Ulcer
Term
What stage pressure ulcer is this?

• Full thickness skin loss
• Damage to subcutaneous tissue
• May be down to but not through underlining fascia
• Deep crater (with or without undermining)
• May see tunneling or undermining
Definition
Stage 3 Pressure Ulcer
Term
What stage pressure ulcer is this?

• Full Thickness
• Extensive damage (bone, muscle, tendon, joints damage)
• Tissue Necrosis
• May see tunneling or undermining
Definition
Stage 4 Pressure Ulcer
Term
What assessment scale is this?

• Predicts the risk of ulcers
• Higher the number the better

• This scale Looks at
o Sensory perception
o Moister
o Activity
o Mobility
o Nutrition
o Friction and sheering
Definition
Braden Scale
Term
What kind of infection is this?


• Acquired at the hospital
• Usually direct contact
• Often resistant to treatment
Definition
Nosocomial Infection

Staff?
Term
What is MRSA?
Definition
MRSA: Mathicillan Resistant Staph Infectionnt enerocci
Term
What are the 4 chains of transmission?
Definition
• Pathogen – Virus, bacteria, etc.….
• Vector Born (insects)
• Vehicle – Contaminated Food
• Portal – Pathogen enters the new host by inhalation ext…
Term
What are the three lines of immune defense?
Definition
• First Line
o Intact skin, mucos membrains, cilla, gag and cough reflexes, saliva
• Second Line Defense: Inflammatory Response
• Third Line Defense: Immune Response
• Only the immune response is specific to the pathogen
Term
Name this Pathogen?

o Major opportunistic infection
o Nosocomial
o Very Distinct Odor / Color greenish yellow
o Associated in the hospital with pneumonia wound infection, UTI’s
o Thrives On moist environment
o Cleaning soulutions, flowers, pools
Definition
Pseudomonas
Term
Name this Pathogen?


o Herpes Virus
o Risk is increased with age
o Asymptomatic or few symptoms
o Sever consequences for the fetus or immune compromised
o Can be transmitted by human contact or placenta
o Can be acquired via transplant
o Course of illness can be mild or very severe from splenomegaly or hepatitis, to MR, blind, hearing loss ext…
Definition
Cytomegalovirus (CMV)
Term
Name this Pathogen?


o Epstein Bar Virus
o Member of the herpes family
o Transmission is through oral secretions (kissing) among others
o Incubation period (4 – 6) weeks
Definition
Mononucleosis (virus)
Term
Name this Medical Condition?


o Can be horrific
o Invasion of the fascia caused by multiple pathogens
o Can occur anywhere – common on LE
Definition
Necrotizing Fasciitis
Term
Name this Medical Condition?

o Vector born infectious disease (tick is the vector)
o Injects saliva with bacteria
o Incubation
o Multisystem disease
o Early Treatment with antibiotics is good
o Three Stages
Definition
Lyme Disease
Term
What happens in stage 1 of Lyme Disease?
Definition
o Stage I
• Red Rash
• Flu like symptoms
Term
What happens in stage 2 of Lyme Disease?
Definition
• Infection spreads to nervous system
• Affects Nervous System
• Cardiac Signs and Symptoms
Term
What happens in stage 3 of Lyme Disease?
Definition
• chronic neurological involvement, late persisten infections
• Intermittent arthritis with pain and swelling
Term
Name this Medical Condition?

o Infectious agent enters through open wound
Infectious agent enters through open wound
o Bone
o Can spread quickly through the bloodstream
o Will cause septicemia or septic join
Definition
Osteomyelitis (inflammation of the bone due to infections)
Term
Name this Medical Condition?


• When the heart and artery can not maintain pressure to the organs we go into shock
• Not enough O2 to meet metabolic needs

o Tachycardia, tachypnea, cool extremities
o Depcreased pulses, decreased urine otput, AMS, hypotension
Definition
Shock
Term
Name this Organ?

You often see Its enlargement in many diseases mainly because its main function is to fight disease. it is part of the lymphatic system, which fights infection and keeps your body fluids in balance. it contains white blood cells that fight germs and also works to control the amount of blood in your body, and destroys old and damaged cells. So certain diseases might cause it to swell.
Definition
Spleen
Term
What is Hematocrit?
Definition
HEMATOCRIT (HCT)- The hematocrit refers to the 'percentage' of one's red blood cells.
Term
What is the normal HEMATOCRIT (HCT) levels:

Male and Female?
Definition
Normal Adult Female Range: 36 - 46 percent
Normal Adult Male Range 41 - 53 percent
Term
Who Am I?

I am a protein that is carried by red cells. I pick up oxygen in the lungs and deliver it to the peripheral tissues to maintain the viability of cells. I am made from two similar proteins that "stick together". Both proteins must be present for me to pick up and release oxygen normally. One of the component proteins is called alpha, the other is beta. Before birth, the beta protein is not expressed. My protein is found only during fetal development, called gamma, substitutes up until birth.
Definition
HEMOGLOBIN (HGB)
Term
what are the normal hemoglobin levels:

Male and Female?
Definition
Normal Adult Female Range: 12.0 - 16.0 g/dL
Normal Adult Male Range: 13.5 - 17.5 g/dL
Term
Name this medical condition?


• rare complication of a transfusion
• Acute allergic reaction
• Respiratory Failure
• Organ Failure
• Requires Epinephrine
Definition
Anaphylaxis
Term
Surgery without requiring transfusion is called what?
Definition
Bloodless Medicine
Term
What is this? the most common type of blood cell and the vertebrate organism's principal means of delivering oxygen (O2) to the body tissues via the blood flow through the circulatory system. They take up oxygen in the lungs and release it while squeezing through the body's capillaries.
Definition
Erythrocytes
Term
Name this medical condition?

a decrease in number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin deficiency.
Definition
Anemia
Term
Name this Medical Condition?

• Lots Of Blood Loss (Hemorrhaging)
• Increased Destruction of RBC’s (autoimmune) (congenital)
• Decreased Production RBC’s
• Relationship between Aspirin (NSAID) and GI Bleeds
Definition
Anemia:
Term
Name this Medical Condition?


o Lack of erythropoietin
o Infection
o Vitamin B12 Deficiency (Mal Absorption Problem) Missing Factor
o Pernicious Anemia (Vitamin B12 problem)
o Deficiency of Folic Acid (Alcohol Abuse) (Over Cooked Food)
o Iron Deficiency
• Decreased oxygen carrying capacity of the blood
• Due to abnormal RBC quality or quantity
Definition
Anemia
Term
Who am I?

I am cells of the immune system involved in defending the body against both infectious disease and foreign materials.
Definition
Leukocytes or White blood cells (WBCs)
Term
Name this Medical Condition?


• Below 5000 (like in HIV, Alcohol abuse, Connective Tissue disorder, ext..)
• Never a good thing
• Cant fight infection!
• Can be iatrogenic
• 7 -14 days must susceptible to infection
• Ulceration of mucus membranes
Definition
Leukopenia: Decreased number of WBCs
Term
what are the three big groups of white blood cells?
Definition
• Granulocytes (leukocytes)
• Monocytes (Mature Macrofasias, eating up stuff)
• Lymphocytes (B and T-cell immunity)
Term
what kind of bone marrow transplant comes from the same species?
Definition
• allogenic – Homograft
Term
what kind of bone marrow transplant comes from yourself during remission?
Definition
• autologs
Term
what kind of bone marrow transplant comes from identical twins?
Definition
• isograft – syngenic
Term
What type of transplant?


• peripheral blood stem cells are taken from the persons own stem cell through leukaphersis
• cord blood
Definition
Stem Cell Transplant
Term
name this medical condition?

Type of cancer of the blood or bone marrow characterized by an abnormal increase of white blood cells.
Definition
Leukemia
Term
Name this medical condition?


• Malignant neoplasm (Cells that go array) of the blood forming cells
• Normal bone marrow is replaced by a malignant clone
• Accumulation of neoplastic immature lymphoid or myeloid cells in the bone marrow and peripheral blood 20 – 30 percent lymphoblast’s in the blood
• Chronic is slower progressing
• Crowding of abnormal cells spilling into peripheral circulation inhibiting normal blood flow circulation
o Anemia (reduced tissue oxygen)
o Bleeding from decreased platelet production
o Infection from neutropenia
• Treatment (Bone marrow transplant, chemo, ext….
• Goal is complete remission 5 year mark
• Acute Bigger Concern
Definition
Leukemia
Term
Name this Medical Condition?

A cancer in the cells of the immune system. Typically, present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage of the disease. These malignant cells often originate in lymph nodes, presenting as an enlargement of the node (a tumor). It can also affect other organs in which case it is referred to as extranodal
Definition
Lymphoma
Term
Name this medical condition?


• Histological (skin)
• Find Giant Reed Sternberg cells in the lymph nodes
• Can spread to spleen, bone marrow, liver, lungs
• Classic form can be child or adult
• Peaks at 25 – 30 and after 50
• Classic non tender Firm nodules
• Leads to immunodeficiency and infection
• Goal is CURE
Definition
Hodgkin's lymphoma:

previously known as Hodgkin's disease, is a type of lymphoma, which is a cancer originating from white blood cells called lymphocytes.
Term
Name this medical condition?


• Solid tumors from cell lymphatic system
• Lymph nodes involved first and then any other extra nodal lymphoid tissue
• Mainly spleen and thalamus
Definition
non-Hodgkin lymphomas
Term
Name this medical condition?

A cancer of plasma cells, a type of white blood cell normally responsible for the production of antibodies.[1] Collections of abnormal cells accumulate in bones, where they cause bone lesions, and in the bone marrow where they interfere with the production of normal blood cells.
Definition
Multiple myeloma, also known as plasma cell myeloma or Kahler's disease
Term
Name this medical condition?


• Plasma cell problem
• Blood is made up of (Formed Element (RBC, WBC, Platelets, PLASMA)
• Bone marrow disease
• Initally affects bone marrow of the vertebrae, ribs, skull, pelvis, femur,
• Later spleen liver, kidney
• Peaks 50 -70
• Black > white
• Men > women
• Highly associated with aids
• Platelet cells are called thrombocytes (blood clotting cells)
• Onset is insidious
• NO CURE
• Difficult to treat
• 3 year survival rate
Definition
Multiple myeloma, also known as plasma cell myeloma or Kahler's disease
Term
Name this medical condition?


• uncontrolled expansion of all bone marrow elements
• can progress to leukemia
Definition
Myeloprolifrative
Term
What is Thrombocytosis?
Definition
increased number of circulation platelets
Term
What is Thrombocytopenia?
Definition
decreased number of platelets
Term
A Single dose of aspirin can suppress normal platelet aggregation for how long?
Definition
48 hours to 1 week
Term
Name this medical condition?


• Condition of over activation of normal coagulation
• Results in clotting and hemorrhaging all over the body uncontrolled
• Clotting Pressure breaks tissue causing bleeding
Definition
Disseminated Intravascular Coagulation (DIC)
Term
Name this medical condition?


• Hereditary – Both Parents
• Chronic
• Afro Americans, Spanish speaking regions of the world
• Erythrocytes rupture and form sickle shaped cells
• Hemoglobin releases prematurely
• Sickled cells are sticky and stiff and get stuck
• Abnormal cells obstruct blood flow
• Less oxygen goes to tissue
• Sickling happens during de-oxogenation
• Sickling Begins at 6 weeks, does not manifest until 6 months
• Can DNA test by 10th gestation (genetic)
• No Cure
Definition
Sickle Cell Anemia
Term
Name this Medical Condition?


• Male disease (Female Carrier) Like Duchene MD
• Abnormality of plasma clotting proteins
• Hemophilia A is most classic (Factor A Deficiency)
• Bleeding is prolonged (not faster) Flow remains the same
• Level of clotting factor is always the same amongst family members
Definition
Hemophilia
Term
Name this Medical Condition?

The most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions. It arises from a qualitative or quantitative deficiency of a certain factor, a multimeric protein that is required for platelet adhesion.
Definition
von Willebrand disease (vWD)
Term
• Affects both men and women
• Most cases are mild
• More common in Caucasian women
• Nose bleeds or bleeding gums
• Bleeding can be prolonged
most common hereditary coagulation abnormality
Definition
von Willebrand disease (vWD)
Term
Can females suffer from hemophilia?
Definition
• Females can become hemophiliacs
• if the female has only 1 x and the x is affected a female can get hemophilia
• or can be on both x’s (rare)
Term
what is a Primary Immunodeficiency?
Definition
o Congenital
o Failure of an organ to develop
Term
What is a Secondary Immunodeficiency
Definition
o Due to underlying disease
o Anything that can depress or block the immune system
Term
The pituitary gland is also known as what?
Definition
The master gland
Term
What gland controls the immune system?
Definition
• Pituitary gland (master gland)
Term
• Moderate exercise enhances what system?
Definition
The immune system
Term
• The type of antigen causes what type of immune response
Definition
a specific
Term
what is an innate immunity?
Definition
o First line defenses
o Always responds the same way
Term
what is an acquired immunity?
Definition
o Immune Reaction
o Pathogen enters body, recognized and destroyed
o MEMORY (can get stronger)
Term
T lymphocytes called T cells originate in the bone marrow and mature where?
Definition
in the Thalamus (T for T)
Term
What is the helper T cell called?
Definition
•CD4:

There are different T cells, one kind is the helper T cell also called CD4
• CD4 is destroyed by aids
• The lower the CD4 count the worse
Term
Is it better to have a high CD4 count or low
Definition
• CD4 is destroyed by aids
• The lower the CD4 count the worse
Term
• B Lymphocytes originate in bone marrow and mature where?
Definition
mature in the Bone (B for B)


• Antibodies in B cells are present in different body fluids
• Bone marrow transplant will give immunity
Term
name this medical condition?

a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections.
Definition
HIV AIDS : Human immunodeficiency virus (HIV) is a lentivirus (a member of the retrovirus family) that causes acquired immunodeficiency syndrome (AIDS)
Term
Name this medical condition?


• Progressively destroys T Cells
• Very susceptible to opportunistic infections
• Transmission is exchange of body fluids
• Latency period (8-10 years)
• AIDS means you are HIV positive
• AIDS = CD4 count less than 200
• Normal CD4 = 600 -1200
• HAART (Antiviral Drugs) – Take when CD4 below 500
• HIV can be asymptomatic
• Night Sweats and Weight Loss
• Palliative Care – keep someone comfortable
• Children might die quicker due to immature immune system
• Leading cause of death now Kidney or Liver failure
• Exercise good (increase CD4 COUNT)
Definition
HIV AIDS : Human immunodeficiency virus (HIV) is a lentivirus (a member of the retrovirus family) that causes acquired immunodeficiency syndrome (AIDS)
Term
Name this medical condition?

• Yuppie Flu
• Epstein Bar Virus (herpes)
• Neuroendocrine deregulation, CNS dysfunction, Hormonal deregulation
• Mono like symptoms
• Muscle pain and forgetfulness
• Exacerbations and remissions
• Mostly Chronic
• Not resolved with rest
Definition
Chronic fatigue syndrome
Term
Name this medical condition?


• Exaggerated or inappropriate immune response
• Type 1 (typical allergic reactions)
o Anaphylactic reactions
• Three other types
Definition
Hypersensitivity DS
Term
Name this medical condition?


• Chronic
• Autoimmune DZ
• Women more than men
• Systemic problems (all over problems)
• Autoimmune (Tissues are destroyed)
• Butterfly rash
• Therapy helpful because of stress factors
Definition
Lupus (systemic)
Term
Name this medical condition?


• 11 tender points
• women more than men
• wide spread (Chronic)
• Rheumatology (disease affecting joints, muscle, and bones)
• Hyperthyroidism
• Myofascial pain is local
o Wide spread pain
o Bilateral above and below waist
o More than 3 months
o 11 to 18 common tender points
Definition
Fibromyalgia
Term
What body system is this?


• Comprised of multiple glands
• Glands synthesize hormones
• Hormones are transported by way of the blood system
• sends messages by way of the blood stream
• Slow onset but long acting
Definition
Endocrine System
Term
what are the 5 general functions of the endocrine system?
Definition
o Stimulation of growth in fetus
o Childhood and adolescents growth
o Coordination between male and female glands
o Maintain optimal living environment through our life
o Correcting modulation adaptive responses
Term
what controls the pituitary gland?
Definition
• Hypothalamus controls the pituitary gland
Term
How does the Hypothalamus regulate the pituitary gland?
Definition
• Simple: Level of one substance regulates the secretion of a hormone. (Level is low…. Secretion of that need takes place)
• Complex: Injury or major stress occurs so substance is released and then secretion takes place, substance after substance
Term
Endocrine Problems occur from what?
Definition
From over secretion or under secretion due to

o Infections
o Tumors
o Reponses to stress
Term
(cataacolimine) is involved in what part of the nervous system?
Definition
Sympathetic

o Fight or flight – Blood vessels constrict and ready you for action
Term
(cortisole) is involved in what part of the nervous system?
Definition
• Para sympathetic

Released from adrenal Glands
o Calms you down
Term
how many different hormones are in the anterior pituitary gland?
Definition
6
Term
What are the two Disorders of Anterior Pituitary causing (hyperpotitaryism)
Definition
o Acromegally
o Gigantism
Term
Name this medical condition?

o hyperpotitaryism
o Happens before epiphysis of bone
o Slow insidious
o Does not get growth in long bones
Definition
o Acromegally
Term
Name this medical condition?

o hyperpotitaryism
o Happens when people are growing
o Over growth of long bones
o Abrupt course of development (happens before your eyes)
o Facial Features (jaw bone protrudes, Facial features are course, hand get broad, thick tongue, ext)
Definition
o Gigantism
Term
Name this Medical Condition?

Anterior Pituitary :
o Affects all 6 hormones
o 75% of the pituitary gland must be damaged for affects to show up
o Causes (panhypopitutiaryism)
o Hypophysectomy
o Poor nutrition (anorexia)
o Delayed growth
o Delayed puberty
o Hypothyroidism (connection to pituitary)
Definition
Panhypopitutayism
Term
Name 2 Posterior Pituitary Gland Disorders?
Definition
o Diabetes Incipits (makes you pea allot)
o SIADH ( syndrome of inappropriate antidiuretic hormone (Can Not Pea)
Term
Name this medical condition?


o Deficiency of ADH (anti diuretic hormone)
o Incipits (polyuria, polydipsia)
o Could be iatrogenticly induced
o Urinate a lot
Definition
o Diabetes Incipits (makes you pea allot)
Term
Name this Medical Condition?


o Increased ADH
o Bloating
o Can not Urinate
Definition
o SIADH ( syndrome of inappropriate antidiuretic hormone (Can Not Pea)
Term
What Gland?

o Can have wide spread affects
o Can change consistency of hair, nails, ext
Definition
Thyroid Gland
Term
Name this medical condition?


o Metabolism that is racing
o Likes the cold
o Tachycardia
o Trouble with nutrition
o Bulging eyes
o Thyroid storm (acute episode)
o Stress brings on storm
o Thyroid is over active
o High fever
Definition
Hyperthyroidism
Term
Name this Medical Condition?

disease where the thyroid is overactive, producing an excessive amount of thyroid hormones (a serious metabolic imbalance known as hyperthyroidism and thyrotoxicosis).
Definition
Graves' disease
Term
Name this medical condition?

o Enlarged thyroid gland (symmetrical)
o Losing weight with big appetite
o Tend to be more nervous and heat intolerant
Definition
Graves' disease
Term
Name this medical condition?

o Female Condition greater than male
o Middle age victims
o Primary or secondary condition
o Likes it warm (gets cold)
o Weight Gain
o Less Thyroid Hormone
o GI Tract does not eliminate waste
o Bradycardia
o Increased risk of CAD and altersclorsis
o Skin is dry… Dry hair ext….
o Myxedema
Definition
Hypothyroid Condition
Term
What is a Goiter?
Definition
Goiter (enlarged Thyroid Gland)
o Iodine Deficiency
o Pressure on trachea and esophagus
Term
Name this Medical Condition?


o Inflammation of the thyroid
o Acute pus forming
o Sub acute granular infection
Definition
Thyroiditis
Term
name this medical condition?

an autoimmune disease in which the thyroid gland is gradually destroyed by a variety of cell and antibody mediated immune processes.
Definition
Hashimoto's thyroiditis
Term
Name this medical condition?

o Inflamed thyroid
o Women more than men
o Autoimmune based with genetic predisposition
o Linked with other autoimmune disease
o Leads to destruction of the thyroid gland
o Leads to hyper function of goiter
o Painless symmetrical enlargement
o Can find genetic markers
Definition
Hashimoto's thyroiditis
Term
True or false?

The parathyroid is apart of the thyroid?
Definition
False

The Parathyroid is not a thyroid
Term
What is Hyperparathyroidism?
Definition
Hyperparathyroidism: (over secretion of the parathyroid hormone)

Vonwrilanhousand Disease ( Hyperparathyroidism)
Term
Name this Medical Condition?

o Parathyroid gland regulates calcium and phosphate metabolism
o causes to much calcium in the blood and not enough in the bone
o Excessive osteoclasts (break down bone)
o Pathological fracture (caused by disease, not traumatic fracture)
o Litic lesions (holes in bones)
Definition
Hyperparathyroidism (over secretion of the parathyroid hormone)

Vonwrilanhousand Disease ( Hyperparathyroidism)
Term
Name this medical condition?

o To little calcium in the blood
o High level of fosfate
o Calcification of organs
o Calcium dposits on eye and brain
o Tetney (hypofunction para thyroid
Definition
Hypoparathyroidism (under secretion of the parathyroid hormone)
Term
Name this Medical Condition?

o Primary Adrenal Insufficiency
o Adrenal gland dysfunction
o Primary adrenal insufficiency
o Decreased production of cortisol and aldosterone
o Found in the CORTEX
o Cortisol
• Cortisol diffiencny causes hypoglycemia
• Tanned bronze looking
o Aldosterone
• Fluid and electrolyte imbalance
Definition
Addisons Disease
Term
Name this medical condition?

Hyper function (adrenal Gland)

o Increase in cortisol
o Big moon face
o Don’t heal well
o Can get fatty buffalo hump
o Muscle weakness
o Steroid use long term can cause cushings syndrome
Definition
o Cushing’s Disease

o Cushing’s Syndrome (iatrogenic)
Term
Name this medical condition?

Hyper function (adrenal Gland)


o Increased Aldosterone
o Causing too much reabsorbtion by kidney
o Hypermaytima (increase sodium in the blood)
o Hypervolimia (increased blood volume)
o Increased blood Pressure
Definition
o Crons Disease
Term
T or F

• Gland might enlarge due to over or under secretion
Definition
True
Term
Pressure in the area of the hypothalamus and pituitary gland can cause damage to what nerve
Definition
optic nerve (optic nerve compression)
Term
Name this Medical Condition?


o Chronic systemic problem of Pancreas
o Leading cause of blindness
o Leading cause of renal failure
o Two Types
o Hyperglycemia
Definition
Diabetes
Term
What are the two types of Diabetes?
Definition
o Type I -Not enough insulin being produced or No insulin
o IDDM insulin dependent diabetes mellitus


o Type II - In effective insulin production
o NIDDM non insulin dependent diabetes mellitus

o Both are Hyperglycemia
Term
Which form of Diabetes is this?

o Abrupt onset
o Viral problem
o Autoimmune problem
o Normal – not over weight
o Watch diet
Definition
IDDM – Type 1 (Juvenile)
Term
Which form of Diabetes is this?

o Overweight
o Low exercise
o Poor diet.. fatty sugar
o Insidious (gradual)
o Large demand on pancreas
o Take hypoglycemic agents to help control sugar
o Might need insulin
Definition
NIDDM – Type II (adult)
Term
What are the normal ranges of glucose levels?
Definition
o < 70 – 100 norm
o less than 70 shock
o greater 300 coma
o greater 125 diabetes
Term
A glucose level of less than 70 will produce what?
Definition
Shock
Term
A glucose level between 70 and 100 will produce what?
Definition
Normal Body Function

70 to 100 is normal!
Term
A glucose level greater than 300 will produce what?
Definition
COMA
Term
A glucose level greater than 125 will produce what?
Definition
Diabetes!
Term
Name this Medical Condition?


o Ulceration on feet from stress and pressure you don’t feel
o Brittle (not well controlled)
o Joints tend to collapse due to improper alignment (charco joint)
o Degeneration of joints due to weight bearing
o Increased fat metabolizing in blood… causing arthrosclerosis
o Polyuria (with glucose)
o Proximal muscle weakness
Definition
Diabetes
Term
Too much insulin causes what medical condition?
Definition
Insulin shock
Term
To be considered Hypoglycemic you insulin levels should be what?
Definition
Less than 70
Term
If you don't have enough insulin what will happen to you?
Definition
Diabetic Coma (not enough insulin)

o Hyperglycemic
o Greater than 300mg
o Gradual onset
Term
Name this type of Diabetes?

o Polyuria (with glucose)
Definition
Diabetes Mellitus
Term
Name this medical condition?

an autosomal recessive metabolic genetic disorder characterized by a deficiency in the hepatic enzyme phenylalanine hydroxylase
Definition
Phenylketonuria (PKU)
Term
Name this medical Condition?


o Congenital
o Untreated will cause retardation
o Lacking enzyme to convert amino acid
o Seizers, tremors, pour muscular
o Screening to avoid
Definition
Phenylketonuria (PKU)
Term
Name this medical condition?

an autosomal recessive genetic disorder in which copper accumulates in tissues; this manifests as neurological or psychiatric symptoms and liver disease. It is treated with medication that reduces copper absorption or removes the excess copper from the body, but occasionally a liver transplant is required.
Definition
Wilson's disease or hepatolenticular degeneration
Term
Name this medical condition?

o Progressive disease
o Defect in metabolism
o Not metabolizing copper
o Accumulates in organs
o Ciser Phlisher Eye Rings
Definition
Wilson's disease
Term
What does Anaplastic / aplasia mean?
Definition
(no characteristics of parent cells)
Term
True of False?

Less differentiated the cells the poorer the prognosis
Definition
True!
Term
What does Dysplasia mean?
Definition
(change in cell shape)
Term
True or False?

Dysplasia Can reverse or progress to cancer
Definition
True
Term
What is Metaplasia?
Definition
o Metaplasia (earliest form of dysplasia)
Term
What is HyperPlasia?
Definition
(increase in the number of cells in the tissue)

Examples:
• Breast enlargement when pregnant
• Calas forms (excessive bone growth)
Term
What is Neoplastic Hyperplasisa?
Definition
• Cancer
• Increase of abnormal tissue
• Tumors do not have a useful function
• Compete for blood supply
Term
What is a primary tumor?
Definition
o Where the problem initiated
o Primary does not mean malignant or benign
o Like in thigh (primary tumor in leg)
o Doctor runs test to decide whether cancer or not
Term
what are the 5 ways you classify a tumor?
Definition
o Differanation
o Tissue of origin
o Anatomical site
o Benine or milgnant
o Cell type
Term
How many stages are their for Cancer?
Definition
4
Term
What are the 4 stages of Cancer... FIll in the blank?

o Stage 0 =
o Stage 1 =
o Stage 2 =
o Stage 3 =
o Stage 4 =
Definition
o Stage 0 – pre malignant
o Stage 1 – early local cancer
o Stage 2 – increased risk to spread
o Stage 3 – local cancer spread around area (non Disseminated)
o Stage 4 – Gone to new organs
Term
a Low Grade Tumor (highly diffracted) grows fast or slow
Definition
Slow
Term
High Grade Tumor (highly differentiated) grows fast or slow?
Definition
More aggressive (fast)
Term
True or False?

Central nervous system tumors tend not to spread
Definition
True
Term
True of False

Bone Cancer pts tend to have less pain than other cancer pts
Definition
False

Bone cancer = Lots of pain!
Term
what are the 5 Common Sites of Metastases?
Definition
o Lymph nodes
o Liver
o Lung (most common site)
o Bone
o Brain
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