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PBL Biochem Ch 35
Metabolism of the Eicosanoids
10
Biochemistry
Professional
08/08/2012

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Term
Red scaly dermatitis
Definition

Caused by deficiency of essential fatty acids

May occur in patients receiving total parenteral nutrition

Term
Glucocorticoids
Definition

Suppress the transcription and translation of COX-2

Induce the synthesis of a protein or family of proteins that inhibit the activity of phospholipase A2

Term
Thromboxane A2
Definition

Predominant eicosanoid in platelets

Vasoconstrictor, platelet aggregation stimulant

Term
Aspirin
Definition

Permanently destroys the COX enzyme by covalently acetylating the active site

Effective in prevention of acute MI

Term
Thromboxane A3
Definition

Less effective in stimulating platelet aggregation than its counterpart

Production stimulated by diets high in polyunsatuated fatty acids

Term
COX-2 Inhibitors
Definition
Complications from these are due to a decrease in PG synthesis but not TX, causing thrombotic tendencies
Term
PGE1, PGE2
Definition
Suppress gastric ulceration by inihbiting HCl secretion
Term
PGE1
Definition

Can be used to treat male impotence

Can maintain PDA until surgery can be performed

Term
PGE2, PGF
Definition

Stimulate uterine muscle contraction

Used to induce labor and control postpartum bleeding

Term
PGI2
Definition
Useful in the treatment of Pulmonary Hypertension
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