Term
| This molecule is the major immunologic target in pemphigus foliaceus in dogs |
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Definition
Desmocollin I
Cloning and Establishment of Canine desmocollin-1 as a Major Autoantigen in Canine Pemphigus Foliaceus |
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Term
| This is the breed most commonly affected with exfoliative cutaneous lupus erythematosus |
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Definition
German Shorthaired Pointers
Some recent success with tx with mycophenolate |
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Term
| What is the major antigen in canine pemphigus vulgaris? |
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Definition
| Desmoglein 3, and maybe also desmoglein 1 sometimes |
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Term
| Name the dominant immunoglobulin isotype found in the positive lupus band test in German shepherd dogs with mucocutaneous lupus erythematosus? |
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Definition
- direct IF reveals a positive IgG lupus band
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Term
| Name 2 auto-antibody targets that have been identified in mucous membrane pemphigoid in dogs. |
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Definition
- NC16 A domain of Collagen 17 and Laminin 332
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Term
| What is the desmosomal antigen targeted in pemphigus foliaceus? |
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Definition
- Desmocollin-1 primarily in dogs
- Dsg 1 and DsC1 are both involved
- The binding of the autoantibody to the cadherins leads to disruption of intercellular adhesion resulting in acantholysis
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Term
| What is the desmosomal antigen targeted in pemphigus vulgaris? |
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Definition
- pemphigus vulgaris (Dsg 3)
- Binding of autoantibody to the cadherins leads to disruption of intercellular adhesion resulting in acantholysis
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Term
| What lesions are due to T lymphocyte-mediated damage of keratinocytes? |
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Definition
- Antikeratinocyte
- Vesicular cutaneous lupus erythematosus
- Exfoliative cutaneous lupus erythematosus
- Discoid cutaneous lupus erythematosus (facial and generalized)
- Mucocutaneous cutaneous lupus erythematosus
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Term
| What dog breeds are predisposed to pemphigus foliaceus? |
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Definition
- Akita
- Chow Chow
- Doberman
- Schipperke
- Labrador
- Australian Shep
- English Cocker
- Chinese shar pei
- Dachshund
- Collies
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Term
| What dog breeds are most predisposed to Pemphigus erythematosus? |
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Definition
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Term
| What dog breeds are most predisposed to Pemphigus erythematosus? |
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Definition
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Term
| What dog breeds are predisposed to Facial vs. Generalized discoid lupus erythematosus? |
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Definition
- Facial: GSD, Collies, Shetland Sheepdog, Siberian husky
- Generalized: Chinese crested and Labrador retriever
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Term
| What dog breeds are predisposed to Mucocutaneous Lupus erythematosus? |
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Definition
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Term
| What dog breed is predisposed to vesicular lupus? |
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Definition
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Term
| What dog breeds are predisposed to Exfoliative lupus erythematosus? |
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Definition
- German shorthair pointer
- Vizsla
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Term
| Name two autoantibody targets that have been identified in mucous membrane pemphigoid in dogs. |
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Definition
- NC16A domain of Collagen 17
- Laminin 332
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