Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Glycopeptides Pharmacokinetics |
|
Definition
can only give IV
renal elimination
highly nephrotoxic |
|
|
Term
| Glycopeptides Clinical Usages |
|
Definition
no dosage/efficacy data
banned in food animals
never use empirically
never use as firs tline |
|
|
Term
|
Definition
Bactericidal
Both time- and concentration-dependent |
|
|
Term
|
Definition
Inhibits cell wall synthesis
Only Gram + aerobes and anaerobes |
|
|
Term
|
Definition
disruptor of cell membranes and endotoxin effect
pokes holes in membranes of bacteria
only Gram - (aerobes and anaerobes) and Pseudomonas |
|
|
Term
|
Definition
bactericidal
concentration-dependent |
|
|
Term
| Polymyxins Pharmacokinetics |
|
Definition
|
|
Term
| Polymyxins Adverse Reactions |
|
Definition
| nephrotoxic and neurotoxic when use systemically |
|
|
Term
| Polymyxins Clinical Usage |
|
Definition
local use so don't have to worry about systemic toxicity
systemic use at lose doses for endotoxic activity
When using low doses, it is not really killing the bacteria
It is binding the LPS but not killing
And taking chance of developing resistance
If you use it at low doses, need to have another antibiotic on board
It will kill any resistant bacteria
But this is a dangerous game to play |
|
|
Term
|
Definition
inhibitor of cell wall synthesis
mainly against Gram + |
|
|
Term
|
Definition
bactericidal
time-dependent |
|
|
Term
| Bacitran Adverse Reaction |
|
Definition
highly nephrotoxic when use systemically
mostly used topically |
|
|
