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Pharm 12
Golan Second Edition
30
Pharmacology
Graduate
02/11/2011

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Cards

Term
Dopamine Precursors
Definition
L-dopa
Term
Levodopa
Definition
Parkinson's disease. (Dyskinesia, heart diease, orthostatic hypotension) [malanoma, narrow-angle glaucoma, MAOI] Administered with Carbodopa
Term
Dopamine receptor Agonists
Definition
Bromocriptine, Pergolide.
Pramipexole, Ropinirole.
Term
Pramipexole and Ropinirole
Definition
Parkinson's disease and Restless leg for ropinirole. (Diskenesia, orthostatic hypotension, vivid dreams) [Avoid sedation] longer half lives
Term
Dopamine Metabolism Inhibitors
Definition
Rasagiline, Selegiline.
Tocapone, Entacapone.
Term
MAO-B inhibitors
Definition
Rasagiline, Selegiline
Term
COMT inhibitors
Definition
Tolcapone, Entacapone
Term
Rasagiline
Definition
Parkinson's. (BBB, GI hemorrhage) [avoid St. John's wort, other MAOI, cocaines, pheochromocytoma] does not form toxic matabolites
Term
Selegiline
Definition
Parkinson's. (BBB, GI hemorrhage) [weight loss, insomnia, confusion] (St. John's wart, other MAOI] high doses inhibit MAO-A, toxic amphetamine biproduct
Term
Tolcapone
Definition
Parkinson's. (hypotension, hyperpyrexia, fulminant hepatic failure, rhabdomyolysis) [Liver Disease, adversia previously] Highly lipid-soluble
Term
Entacapone
Definition
Parkinson's. (Dyskinesia, dystonia, hallucinations) dyspepsia
Term
Amantadine
Definition
Parkinson's disease, influenza A. (Neuroleptic malignant syndrome, excerbation of mental disorder) [Hypersensitivity to amantadine, lovodopa-induced diskinesias
Term
Benztropine
Definition
Parkinson's disease. (Angle-closure glaucoma, psychosis, hyperpyrexia, paralytic ileus) Reduce tremor.
Term
Trihexyphenidyl
Definition
Parkinson's disease. (Angle-closure glaucoma, psychosis) [tardive dyskinesias] Reduce tremor.
Term
Phenothiazines etc
Definition
Chlorpromazine, Thioridazine, Mesoridazine, Perphenazine, Fluphenazine, Thiothixene, Trifluoperazine, Chlorprothixene
Term
Phenotiazine Characteristics
Definition
Psychotic disorder (Parkinsonism, neuroleptic malignant syndrome, tardive dyskinesia) [Myelosuppression, other QT prolonging drugs]
Term
Chloropromazine, perphenazine
Definition
Nausea and vomiting
Term
Butyrophenones
Definition
Haloperidol, Droperidol
Term
Haloperidol
Definition
Psychoses, Tourette's (Same as phenothiazines) [Parkinson's]. Most widely used butyrophenone, IM injection possible
Term
Droperidol
Definition
Nausea and vomiting, anesthesia adjunct (same as phenothiazines) [Parkinson disease]
Term
Loxapine
Definition
Phychotic Disorders (Parkinsonism, phenothiazine adversia) [parkinson's]
Term
Pimozide
Definition
Phychotic Disorders, Tourette's (Parkinsonism, phenothiazine adversia, QT prolongation) [parkinson's] Less alpha-adrenergic receptor blockade so less sedation.
Term
Molindone
Definition
Phychotic Disorders (Parkinsonism, phenothiazine adversia) [parkinson's] Exerts antipsychotic effect on the ascending reticular activating system
Term
Atypical Antipsychotics
Definition
D2 and 5-HT2 blocking. Focus on negative symptoms.
Risperidone, Clozapine, Olanzapine, Queriapine, Ziprasidone, Aripiprazole
Term
Risperidone
Definition
Psychotic disorders, Bipolar disorder (QT prolongation)D2, 5-HT2, a1, a2, H1
Term
Clozapine
Definition
Refractory Schizophrenia (agranulocytosis, weight gain) [myeloproliferative disorders] not first line. D1-5, 5-HT2, a1, a2, H1
Term
Olanzapine
Definition
Psychotic Disorders, Bipolar disorder. (Anticholinergic symptoms, sedation, weight gain)D1-4, 5-HT2, a1, H1, muscarinic
Term
Quetiapine
Definition
Psychotic disorders, Bipolar disorder (typical atypical antipsychotic) D1, D2, 5-HT1, 5-HT2, a1, a2, H1
Term
Ziprasidone
Definition
Psychotic disorders, Bipolar disorder. (QT prolongation) [arsenic trioxide, chlorpromazine, anti-arrhythmics, QT prolongation] D2, 5-HT1, 5-HT2, a1, H1
Term
Aripiprazole
Definition
Psychotic disorders, Bipolar disorders. (typical atypical antipsychotic) D2, 5-HT1A and partially 5-HT2A
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