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Pharm - B-Lactams
PA School
40
Pharmacology
Graduate
02/06/2010

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Term
4 groups within B-lactam abx:
Definition
1. PCNs
2. Cephalosporins
3. Carbapenems
4. Monobactams
Term
b-lactams, time dependent or concentration dependent?
Definition
time dependent
Term
One B-lactam that in contraindicated in the third trimester of pregnancy:
Definition
Ceftriaxone (rocefin)
Term
one B-lactam that saftey in children and prego have not been estab:
Definition
Doripenem
Term
B-lactams are the prefered abx for this typer of serious infection:
Definition
Meningitis/Ecephalitis; good penetration of BBB w certain B-lactams
Term
4 B-lactams that have good penetration of the BBB:
Definition
1. PCN
2. Carbapenems
3. 3&4th Gen Cefalosporins
Term
Which of the B-lactams are NOT renally eliminated?5
Definition
1. nafcillin
2. oxacillin
3. piperacillin
4. Ceftriaxone
5. cefotaxime
Term
4 Natural PCNs:
Definition
1. Aqueous Crystalin PenG
2. Procain PenG
3. Benzathine PenG
4. PenVK
Term
Natural PCNs cover:
Definition
1. Gram +
2. Oral anaerobes
3. Syphilis
Term
3 Penicillinase resistant PCNs:
Definition
1. Nafcillin
2. Oxacillin
3. Dicloxacillin
Term
penicillinase resistant pcn cover:
Definition
staph and strep only
Term
methicillin refers to which class?
Definition
penicillinase resistant pcn
Term
2 aminopenicillins
Definition
Amoxicillin and Ampicillin
Term
aminopenicillins cover:
Definition
1. G+
2. some G-
3. Anaerobes
4. listeria
5. enterococcus
Term
if you suspect meningitis then give __________ on admit.
Definition
ampicillin
Term
2 Extended Spectrum PCNs:
Definition
1. CArboxypenicillins (Ticarcillin)
2. Ureidopenicillin (piperacillin)
Term
ticarcillin and piperacillin cover:
Definition
1. G+
2. G-
3. Anaerobes
4. Pseudomonas
5. Pipercillin covers enterococcus
Term
4 B-Lactamase Inhibitor Combinations
Definition
1. Augmenton
2. Timentin
3. Unasyn
4. Zosyn
Term
B-lactamase inhibitor combinations cover:
Definition
1. G+
2. G-
3. Improved Anaerobes Coverage
4. Pseudmonas
Term
AS you move up in generation of Cef. what happens to coverage?
Definition
as you move up in generations you get less G+ coverage and more G- coverage
Term
2 First Gen Cephs:
Definition
1. Keflex
2. Ancef
Term
first gen ceph covers:
Definition
1. G+
2. Limited G-
Term
4 second gen cephs:
Definition
1. Ceclor
2. Cefzil
3. CEftin
4. Mefoxin
Term
2nd Gen Ceph Cover:
Definition
1. G+
2. G-
3. Anaerobes
Term
6 Thrd Gen Cephs:
Definition
1. Claforan
2. Rocephin
3. Fortaz
4. Vantin
5. Omnifcef
6. Cedax
Term
Third GEn Cephs Cover:
Definition
1. Limited G+
2. G-
3. Fortaz covers Pseudomonas
Term
fourth Gen CEph:
Definition
Maxipime
Term
Fourth Gen CEph Covers:
Definition
Excellent G+/G- coverage
Term
Ceph: 'Higher Doses Used for CNS infections"
Definition
Maxipime
Term
B-lactams often used for intra-abdominal infections, bacteremia, & UTIs
Definition
Carbapenems
Term
Carbapenems Cover:
Definition
1. G+
2. G-
3. Anaerobes
4. Pseudomonas Except Eratapenem
Term
4 Carbapenems:
Definition
1. Imipenem
2. Meropenem
3. Eratapenem
4. Dorioenem
Term
WHich B-lactam is indicated for ESBLs?
What is an ESBL?
Which BActeria are ESBL?
Definition
Carbapenems are indicated for Extended-spectrum B-lactamases, seen in Klebsiella, E.coli, Enterobacter, Pseudomonas
Term
monobactam = ?
covers?
Definition
Aztreonam covers G- ONLY
Term
bacteria that B-lactams are contraindicated in:
Definition
MRSA
Term
Protocol for rash sensativity to B-lactams
Definition
Use with caution but can switch classes. All B-lactams contraindicated in those w anaphylatic rxns or SJS
Term
B-Lactam for Syphilis:
Definition
Natural Penicillins
Term
B-LActams for Listeria:
Definition
Aminopenicillins
Term
B-Lactams for Enterococcus:
Definition
1. Aminopenicillins (Amox/Amp)
2. Pipercillin
3. Zosyn
Term
B-lactams for Pseudomonas:
Definition
1. ticarcillin
2. Pipercillin
3. PCN/B-lactamase inhibitor Combos
4. Ceftazidime (fortaz)
5. Emepenems (except Eratopenem)
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