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-2600 BC -earliest know records of pharmacy -priest/apothecary/physician in one -pharmakon (charm/spell) |
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-2000 BC -Shen Nung -discovered Ma Hung (Ephedra) -wrote Pen T'sao (365 herbal drugs) |
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-3000 BC -"Papyrus Ebers" (1550 BC) -800 formulas and prescriptions -700+ drugs |
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-460 BC -Father of Medicine -changed Pharmakon to "remedy" -Hippocratic Oath -theory of 4 humors |
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-black bile, phlegm, yellow bile, blood |
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-300 BC -Father of Botany -Pharmacognesy (pharmacy knowledge) -natural products/herbals |
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-1AD -Greek physician/botanist -Materia Medica (encyc. of drugs) -discovered opium/ergot |
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-130 AD -Greek pharmacist/physician -original "drug compounder" -"Galenic" Pharmacy - galenicals/vegetable drugs |
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-Patron Saints of Pharmacy -300 AD -twin Arabian bros -devout Christians -served the poor |
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-700 AD -separated apothecary "compounder" from physician -local spices/herbs |
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Separation of Pharmacy and Medicine |
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-1240 AD -German Emperor Frederick II -Pharmacist's Oath -link to chemistry |
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-1790 -swedish pharmacist discovered primary chemicals |
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-1805 -isolated morphine -quinine, caffeine, codeine |
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-aspirin (ASA) -barbituates |
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-syphilis (arphanamine) -synthetic curative drugs |
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-1729-1825 -Marshall Apothecary -Apprenticeship training -Chemical manufacturer |
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-1752 -Penn. Hospital -by Roberts and Morgan |
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-1821 -Philadelphia College of Pharmacy |
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-1852 -promote communication and standards in pharmacy |
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-1778 -32 page booklet of 100 preps |
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Massachusetts Pharmacopeia |
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-1808 -536 drugs and preps |
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-1820 -217 drugs and preps |
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-1888 -additional drugs/formulas -official with Pure Food and Drug Act |
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-1975 -USP-therapeutically active substances -NF-pharmaceutical agents |
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-1906 -purity, strength, quality |
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Food Drug and Cosmetic Act |
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-1938 -result of Sulfanilamide Disaster (antifreeze) -created FDA |
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Durham Humphrey Amendment |
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Kefauver-Harris Amendments |
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-1962 -Thalidomide Disaster -efficacy |
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Comprehensive Drug Abuse Prevention and Control Act |
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-1972 -manufacturers must register with FDA -NDC assigned |
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-Labeler Code -manufacturer/distributor |
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-Product Code -drug formulations |
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-Package code -package size/type |
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-code of federal regulations -updated yearly |
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-federal register -printed daily |
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