Stimulates thyroid gland to produce T4 and T3 which stimulates metabolism; Secreted by anterior pituitary gland

Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis

Hyperthyroid symptoms: ↑HR, arrhythmias, nervousness, hyperkinesia, muscle fatigue, osteoporosis, ↑metabolic rate

Hypothyroidism

Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis

more potent but shorter half life

Hyperthyroid symptoms: ↑HR, arrhythmias, nervousness, hyperkinesia, muscle fatigue, osteoporosis, ↑metabolic rate

Hypothyroidism

Radiation destruction of thyroid parenchyma

Sore throat, sialitis, hypothyroidism

CI: pregnancy or nursing

Hyperthyroidism, patients should be euthyroids or on β blockers before RAI

Inhibit the thyroid peroxidase-catalyzed reactions and blocking iodine organification

Block coupling of the iodotyrosines

Maculopapular puritic rash,

altered sense of taste/smell,

cholestatic jaundice, agranulocytosis

fetal hypothyroidism

Thyrotoxicosis

CI: pregnancy

Slow onset b/c it affects synthesis

Inhibit thyroid peroxidase reactions

Block iodine orgranificaiton

Inhibit peripheral deiodination of T3/T4

Maculopapular puritic rash

hepatitis, agranulocytosis

Hyperthyroidism