Term
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Definition
Is fraction of drug absorbed into the systemic system circulation
F≤1
Systemic absorption |
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Term
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Definition
| absorption through the gut lumen (intestine) |
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Term
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Definition
| absorption through gut wall (gut) |
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Definition
| absorption into the systemic circulation after first-pass hepatic metabolism |
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Term
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Definition
| measure of how much drug given orally will be absorbed into the systemic circulation. |
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Term
| What influences how much drug is absorbed systemically? |
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Definition
| absorption through the gut lumen and wall, and first-pass hepatic metabolism |
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Term
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Definition
primary site for drug absorption
increased surface area
pancreatic enzymes
primary site for pro-drug cleavage to activate drug |
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Term
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Definition
| increase surface area by 600X |
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Term
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Definition
degrade protein and carbohydrates
insulin |
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Term
| examples of pro-drugs to active drugs |
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Definition
enalapril (vasotec) to enalaprilat
valacyclovir (valtrex) to acyclovir |
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Definition
| 3 main vessels for systemic absorption |
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Term
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Definition
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Definition
recatlly: 10-35% absorption
orally: 20-30% absorption |
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Term
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Definition
rectally: variable
orally: rapid |
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Term
| giving a drug by IV admin means ___ is in the systemic circulation |
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Definition
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Term
| giving a drug by PO administration means that _______ will be absorbed into the systemic circulation. |
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Definition
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Term
| IV dose ______________ than your PO dose to achieve the same systemic exposure |
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Definition
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Term
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Definition
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Term
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Definition
| 1 mg PO = (% bioavail)mg IV |
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