Term
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Definition
absorbtion, distribution, elimniation |
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Term
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Definition
microenvironment of receptor |
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Term
Receptor types and speeds |
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Definition
1. Ion channel - fastest 2. Enzyme dimers - 2nd slowest 3. G-protein 4. Steroid Hormone - slowest and in cytoplasm |
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Term
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Definition
=1/affinity = (d)(r)/(dr)
= concentration @ 50% receptors occupied |
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Term
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Definition
ability agonist to impart stimulus from binding receptor either FULL or PARTIAL AGONIST |
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Term
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Definition
Non-linear response to receptor occupancy
*not 100% receptors need to be bound in order to elicit a maximum response* |
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Term
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Definition
Dose at which 50% of maximal effect is elicited |
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Term
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Definition
concentration required to produce required effect (IE affinity) |
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Term
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Definition
Maximum stimulus a drug can impart |
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Term
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Definition
Can be replaced/compensated for with higher doses of agonist... shift dose response curve right
also called competitive |
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Term
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Definition
can actually antagonize full agonists!! |
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Term
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Definition
bind functional groups cannot be overcome by agonist
think warfarin, aspirin, clopidogrel |
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Term
constituatively active receptor |
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Definition
does not need a ligand to assume active conformation
bound by inverse agonist!! |
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Term
drug that occupies only one receptor type |
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Definition
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Term
drug that occupies multiple receptor types but only produces one type of effect at one concentration |
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Definition
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Term
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Definition
LD50/ED50 (always greater than one) |
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