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| What is MRT and what does it equal? |
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MRT is mean resident time, and it is... MRT = 1 = 1 = 1.44T1/2 K (0.693)
T 1/2
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| What is the equation for total body clearance? |
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Cp0 = Initial Plasma Concentration |
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Half-Lifes and corresponding Fraction of dose of drug in body....memorize!! 1T 1/2 Fb = ? 2T 1/2 Fb = ? 3T 1/2 Fb = ? 4T 1/2 Fb = ? 5T 1/2 Fb = ? |
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Fb =0.5 Fb =0.25 Fb =0.10 Fb =0.05 Fb =0.01 |
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The overall elimination rate constant K = ke + km |
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| How do you calculate the total amount of drug in the body at time "t"? |
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| How do you calculate the rate of elimination in the body using the rate elimination constant? |
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Rate of elimination = -kAt |
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Useful Log equation in "y= b - mx" format |
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Log Cp = Log Cp0 - kt 2.303
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This is the fraction of the drug in the body... = e-kt |
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Volume of distribution stuff.... Vd = ? |
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At or Vd = At = Dose Cpt Cp0 Cp0
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MRT = How many Half-lives? |
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1.44 (This can be a conversion to find out how many hours a half-life is). |
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Name the two equations for duration of action, or td |
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td = 2.303 Log Cp0 Log or...... K CpMEC T 1/2 = 0.693 K
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