Term
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Definition
MOA: Non-selective inhibition of COX I&II (prostaglandins)
USE: anti-inflam, antipyuretic, analgesic
SE: gastric ulcers, platelet supression, acute renal failure
Two Types:
- 1st Generation: Non-Selective
- 2nd Generation: CoxII Selective
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Term
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Definition
COX-1 has a "house-keeping" role in regulating many normal physiological processes. As in the stomach lining, where prostaglandins prevent the stomach mucosa from being eroded by its own acid. When non-selective COX-1/COX-2 inhibitors (Ist Gen. NSAIDS) lower stomach prostaglandin levels and cause ulcers of the stomach or duodenum and bleeding.
- Aspirin
- Acetaminophen (Tylenol)
- Indomethacin (Indocin)
- Ibuprofen (Advil, Motrin); Naproxen (Aleve); Ketorolac (Toradol)
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Term
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Definition
Indications:
- Fever
- Chronic Pain
- Migrain
- Myocardial Infraction
- Rheumatic fever
- Kawasaki's Disease
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Contraindication & SE:
- GI ulcers & Bleeding
- Renal Failure (Uricosuric)
- Increased breath rate & depth
- Don't take w/ ETOH
- Given w/viral infx causes Reye's
- Syndrome in kids
- dizziness, tinnitis, vertigo
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Term
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Definition
- Unlike NSAIDs, tylenol is not particularly effective against pain from inflammatory disorders.
- Extra Strength=500mg
- Ultra = extra strength+cafenine for migraine relief
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