Term
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Definition
Class: Carbonic anhydrase inhibitor
MOA: Blocks bicarb reabsorption. Increases Na loss at proximal tubule. Increases K loss at distal tubule.
Cx: Glaucoma, excretion of weak acids, AMS, Epilepsy
CI: Hepatic cirrhosis (decreased NH3 excretion) |
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Term
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Definition
| Carbonic Anhydrase Inhibitor (topical) |
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Term
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Definition
| Carbonic anhydrase inhibitor (topical) |
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Term
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Definition
Thiazide diuretics - prototype
MOA: Inhibits Na resorption at cortical diluting site (independent of acid-base imbalances, inhibited by NSAIDs, dependent on PG synthesis )
Cx: Essential hypertension, generalized edema (CHF)
Effects: Decreased Ca+uric acid excretion, increased K+Mg+Iodine+Bromide excretion, hyperglycemia from decreased insulin release |
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