Term
Initial Combo regimens for HIV
Antiretroviral-naive patients |
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Definition
1) NNRTI + 2 NRTI
2) PI (boosted with Ritonavir) + 2NRTI
3) INSTI + 2 NRTI |
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Term
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Definition
AE:Hypersensitivity rxn (can progress to SJS)
Shold be avoided in 1st trimester pregnancy
Example: Efavirenz |
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Term
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Definition
Examples: Tenofovir + Emtricitabine
AEs: renal elimination so should be cautioned in RF (except Abacavir); hypersensitivity rxns, pancreatitis, hyperlipidemia |
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Term
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Definition
AEs: parasthesias, NVD, disturbances in lipid and glucose metabolism, trunkal fat redistribution
Examples: Atazanavir, Darunavir
(Boosted with Ritonavir) |
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Term
| integrase Strand Transfer Inhibitor (INSTI) |
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Definition
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Term
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Definition
injection site rxns
hypersensitivity rxn
increase in bacterial pneumonia |
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Term
| AEs of Integrase Inhibitors |
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Definition
N/D, HA, pyrexia
CPK elevation |
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Term
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Definition
Pharmacokinetic booster for Protease Inhibitors
Take with food |
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Term
Evaluating Effectiveness of HAART therapy
(Highly Active Antiretroviral Therapy) |
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Definition
1) CD4 count should increase by 50-150 cells/mm3/yr
(accelerated response after the 1st 3months so check every 3 months)
2) Q3 month monitoring of immunologic (CD4 count) and virologic markers (viral load) and physical assessments
**3) Suppression of viral load to below the limits of detection in 12-24 weeks (Below 40–75 copies/mL
) |
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Term
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Definition
Effavirenz should be avoided in 1st trimester
Continue ART: NNRTI + 2 NRTIs (or PI + 2 NRTIs)
If initiated during pregnancy, include ZDV in initial regimen |
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Term
| When is Antiretroviral prophylaxis recommended? |
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Definition
| For all pregnant women with HIV REGARDLESS of viral load |
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Term
| Antiretroviral therapy should also be initiated, regardless of CD4 count, in patients with the following conditions: |
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Definition
| pregnancy, HIV associated nephropathy, hepatitis B virus (HBV) co-infection when treatment of HBV is indicated |
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Term
| Tx for Pneumocystis jiroveci (carinii) pneumonia |
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Definition
| Ist line= Trimethoprim/Sulfamethoxazole (Bactrim/Septra), Pentamidine |
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Term
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Definition
| Pyrimethamine + Sulfadizine |
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Term
| Tx for Cryptococcus neoformans |
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Definition
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Term
| Tx for Mycobacterial infections |
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Definition
| Clarithromycin (or Azithromycin) + Ethambutol |
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Term
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Definition
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