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Physics of MR
Final
43
Medical
Professional
02/13/2014

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Term
Resonant Frequency is determined by...
Definition
isotope being imaged, characteristics of the molecule, strength of the magnetic field (primarily)
Term
Dephasing of protons is caused by...
Definition
non-uniform magnetic field
Term
Averaging is used to...
Definition
Averaging the signals from several repeated acquisitions is used to reduce image noise
Term
Coils
Definition
Surface coils generally pick up less of the noise energy from the patients body because they are small compared to the head and body coils.

They pick up a more intense signal because they are closer to the tissue being imaged.

They do not directly affect image detail or slice thickness.
Term
Flow voids
Definition
With spin echo imaging, bright blood from flow related enhancement is a characteristics of relatively slow flow.

As the velocity increases to faster flow, the flow-void effect takes over.
Term
T1 weighted

T2 weighted
Definition
T1 weighted = short TE, short TR
T2 weighted = long TE, long TR
PD weighted = short TE, long TR

Short T1 = bright............Long T1 = dark

Tissues with short T1 = bright (fat, intermediate sized molecules)

Tissues with short T2 = dark (solids, large molecules)

Tissues with long T1 = dark (small (water) and large (protein) molecules)

Tissues with long T2 = bright (liquids)

T1 > T2 for most biological tissues
Term
TR
Definition
TR = repetition time between pulse sequences

the amount of time that exists between successive pulse sequences applied to the same slice

short TR - T1
long TR - T2
Term
TE
Definition
TE = echo time

represents the time in milliseconds between the application of the 90° pulse and the peak of the echo signal

short TE - T1
long TE - T2
Term
T1 relaxation ("spin-lattice")
Definition
"time for the longitudinal magnetization to return to 63% of its original length"

characterized by the longitudinal return of the net magnetization to its ground state of maximum length in the direction of the main magnetic field

After two T1 times, the magnetization is at 86% of its original length. Three T1 times gives 95%. Spins are considered completely relaxed after 3-5 T1 times.

T1 relaxation is fastest when the motion of the nucleus (rotations and translations or "tumbling rate") matches that of the Larmor frequency. As a result, T1 relaxation is dependent on the main magnetic field strength that specifies the Larmor frequency. Higher magnetic fields are associated with longer T1 times.
Term
T2 relaxation ("spin-spin")
Definition
"time required for 63% of the transverse magnetization to decay"

"measure of the time of disappearance of the transverse magnetization"

T2 time is considerably shorter than the T1 time. Ex) CSF, T1=1.9 seconds and T2=0.25 seconds.

Short T2 = BRIGHT

T2* = loss of signal seen with dephasing of individual magnetizations; basically the relaxation of an individual RF echo pulse versus T2 as a whole
Term
Gradient Echo
Definition
pulses that do not refocus T2* decay

As a result, GE sequences demonstrate more susceptibility artifact for ferromagnetic foreign bodies
Term
Signal intensity on MR is determined by?
Definition
1. proton density
2. T1 relaxation
3. T2 relaxation
4. flow
Term
TR - repetition time
Definition
time between consecutive 90 degree RF pulses

T1 = short TR
T2 = long TR
Term
TE - echo time
Definition
time between the initial 90 degree RF pulse and the echo

T1 = short TE
T2 = long TE
Term
Proton Density sequence
Definition
Short TE (shorty) - more T1ish
Long TR (longer) - more T2ish
Term
FLAIR (Fluid Attenuated Inversion Recovery)
Definition
Basically T2 w/ CSF suppressed
Term
LARMOR FREQUENCY/RESONANCE
Definition
Describes frequency or rate of proton precession

w = yB

w – angular (or precession) frequency (i.e. speed)
y – gyro-magnetic ratio (42.5 for protons)

B – external magnetic field

exposure of an object to RF radiation at the Larmor frequency, causes the net magnetization to spiral away from the Bo field
Term
T1 relaxation
Definition
over time, anti-parallel protons will "relax" into parallel orientation (parallel to the Bo magnetic field); this causes a cumulative effect leading to a net magnetism; the longitudinal magnetization vector grows exponentially over time and the strength of the vector is determined by the number of protons that align in the parallel orientation which itself is dependent on the tissue type and the strength of the magnetic field
Term
T1 relaxation time...
Definition
time it takes the longitudinal magnetization vector to grow to 63% of its max value

5 T1s = saturated
Term
90o RF Pulse
Definition
amount of RF energy required to equalize parallel and anti-parallel orientation

basically the pulse which equalizes parallel and anti-parallel protons so that the only magnetization is transverse in nature (i.e. protons precess synchronously)

Following RF pulse from copper coil, precession of protons is synchronous and a net transverse magnetization develops
Term
T2 relaxation is...
Definition
loss of synchronous precession
CSF relaxation time is very long, muscle is not as long
Term
T2 relaxation time
Definition
time it takes for transverse magnetization vector to diminish to 37% of original length…or put another way the time it takes for transverse vector to diminish 63%; transverse magnetization develops after RF pulse

Observable MR signal from tissue is based on the net transverse vector!
Term
Free Induction Decay (FID)
Definition
diminishing MR signal (i.e. loss of synchronous precession i.e. T2 relaxation)
Term
MR SIGNAL equation...
Definition
Signal = Mxy = M0 (1-e-TR/T1) e-TE/T2

Mxy = transverse magnetization vector
M0 = max longitudinal magnetization (contributed by the proton density of the tissue and can't be changed)
TR = repetition time between pulse sequences
T1 = T1 relaxation time; increases with increasing Bo
TE = echo time
T2 = T2 relaxation time; independent of Bo
Term
Spatial resolution (MR)
Definition
the size of the smallest detectable detail; in MR this is the size of the VOXEL

Smaller voxels = higher spatial resolution (resolution inversely proportional to voxel)
Voxel = FOV/Matrix size (smaller field of view leads to better resolution)
Term
Small FOVs in MR lead to...
Definition
aliasing (wrap-around) artifact
Term
Voxel is/defines...
Definition
3D rectangular solid which defines spatial resolution in MR

smaller voxel = higher spatial resolution = sharper image
Term
Voxel size is determined by...
Definition
matrix size, FOV, and slice thickness

increasing FOV increases voxel size and decreases resolution

increasing matrix decreases voxel size and increases resolution

increasing slice thickness increases voxel size and decreases resolution
Term
Vox Volume
Definition
ST x (FOVphase/MatrixSizePhase) x (FOVRead/MatrixSizeRead)
Term
Slice thickness
Definition
determines depth of voxel; directly proportional to voxel volume; increasing slice thickness leads to greater voxel volume which leads to decreased resolution
Term
MR signal is proportional to...
Definition
voxel volume

increasing signal leads to increased vox vol which leads to decreased spatial resolution
Term
SPIN ECHO
Definition
90o RF pulse >> transverse magnetization >> T2 dephasing (i.e. reduction in transverse mag) >> 180o pulse >> rephrase

After a time TR, sequence is repeated
Only one row of k-space is acquired per each TR period

Less sensitive to magnetic susceptibility and field inhomogeneity; long TR, longer time acq
Term
FAST SPIN ECHO
Definition
RF pulse followed by series of refocusing pulses leading to a series of echoes

Each echo fills one row of k-space
T2 signal gradually decreases during echo collection reducing image sharpness (decr SNR)

Useful for when inhomogeneity and mag susceptibility precludes hi-res images by faster sequences
Term
GRADIENT RECALLED ECHO
Definition
RF pulse less than 90o (creates some transverse mag) >> negative gradient pulse (rapid dephasing of transverse mag) >> positive pulse rephrases transverse mag creating gradient echo @ TE
More sensitive to inhomo field and mag suscept than SE
Shorter TR and fast image time but decreased SNR
Term
ECHO PLANAR IMAGING
Definition
single RF excitation; very short acq times, image contrast T2*; fMRI and DWI
Term
INVERSION RECOVERY (TI)
Definition
starts with 180o RF pulse which inverts tissue magnetization to prepare image contrast

During inversion time, signal is formed by T1 relaxation; thus TI can be used to control T1 contrast of tissues
After TI, standard spin echo sequence performed

Allows suppression of tissue types by manually reducing magnetization of that tissue (this reduces the signal given off from that tissue)

Least susceptible to mag field inhomo and mag suscept

STIR: short tau inversion recovery – FAT (short T1) suppressed as a result of short TI

FLAIR: fluid attenuated inversion recovery – CSF (long T2) suppressed as a result of long TI
Term
Image acquisition time
Definition
TR x Np x NEX

TR = repetition time (time it takes to complete one acq cycle)

Np = number of phase encodes (part of matrix size which determines how many times acq cycle must be repeated)

NEX = number of excitations or averages
Term
MAG SUSCEPTIBILITY
Definition
Magnetic susceptibility describes the behavior of material when placed in external mag field

Diamagnetic, Para, Ferro are classes of materials by susceptibility

Ferromagnetic substances develop strong internal magnetic field parallel to direction of external field which dramatically increases it

Susceptibility artifacts observed where magnetic susceptibility varies rapidly (such as nasal cavity) and result from the presence of metal objects

Commonly in T2-weighted, GE, and Echo planar (DWI) sequences

Appears as image distortion w/ warped anatomy
Appears as signal voids, surrounded by bright rim
Term
ALIASING (wrap-around)
Definition
Tissue excited outside FOV is recorded artificially w/in FOV
occurs when FOV is smaller than the surrounding tissue
Term
GHOSTING
Definition
Duplicated copies of anatomic structures with a reduced intensity
may appears as a blurring or motion

Caused by physiologic and/or patient motion or pulsatile flow (aorta)
Term
TRUNCATION
Definition
Multiple, alternating bright/dark lines (ringing)
Fourier-based imaging technique leads to image errors near sharp boundaries

Typically involved w/ bright signal boundaries such as spinal cord b/t CSF/tissue, other T2 fluid images, or T1 fat
Term
CHEMICAL SHIFT
Definition
shifting of fat in one direction 2/2 misregistration of fat and water

TYPE 1 - fat/water interfaces separate on images - bright band is where fat and water are seen to overlap while dark band is where fat and water are separate
TYPE 2 ("India ink") - boundaries of tissues with large differences in fat/water content are outlined in black - THIS IS OUT OF PHASE IMAGING
Term
ZIPPER
Definition
caused by detection of extraneous RF signals; usually malfunctioning or incompatible medical equipment (syringe pumps, open door to magnet)

thin stippled/dashed band through the image
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