Term
| What is the function of platelets? |
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Definition
| They are primary involved in the hemostasis or maintaining the vascular integrity. They do not have a nucleus |
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Term
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Definition
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Term
| amount of platelets circulating gin the blood |
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Definition
| 2/3 and 1/3 stays in the spleen. |
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Term
| Normal values of platelets |
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Definition
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Term
| The platelet plug cascade |
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Definition
1. Adhesion
2. Aggregation
3. Secretion |
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Term
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Definition
| may lead to abnormal clotting or thrombosis ( reactive increase in platelets) |
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Term
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Definition
| an elevation in platelets count the elevation of platelets is not related to any other secondary condition, but to bone marrow disorder. |
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Term
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Definition
| platelets count decrease (<150,000) |
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Term
| what are the causes of thrombocytopenia? |
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Definition
1. Decreased production
2. Abnormal distribution
3. Increased destruction |
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Term
| Wiskott- Aldrich Syndrome |
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Definition
| Inherited quantitative platelet disorder, which is an immunological disorder, small platelets, disorder of dense granules. |
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Term
|
Definition
| Giant platelets and Dohle body- like inclusions in neutrophils |
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Term
| Glanzmann's thrombasthenia |
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Definition
| defect in platelets aggregation, the platelets count and morphology are normal, caused by the deficiency of the membrane. |
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Term
| Bernard- Soulier Syndrome |
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Definition
| Defect in platelet adhesion caused by deficiency of GP lb/IX complex. Normal to moderately decreased platelets count. Giant platelets. |
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Term
|
Definition
| defect adhesion, problem with one or more portion of the vWF molecule. the first step of the platelets plug cascade will not continue. |
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