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Polymerases
The functions of different polymerases & designation as Prokaryotic or Eukaryotic
11
Medical
Graduate
08/21/2011

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Term
DNA Polymerase alpha
Definition
Tightly interacts w/ Primase; Eukaryotic
Term
DNA Polymerase Beta
Definition
Functions in repair; similar to Pol I of Prokaryotes; Eukaryotic
Term
DNA Polymerase gamma
Definition
Mitochondrial polymerase; Eukaryotic
Term
DNA Polymerase delta
Definition
Polymerase of lagging strand; Eukaryotic
Term
DNA Polymerase epsilon
Definition
Polymerase of leading strand; Eukaryotic
Term
DNA Polymerase I
Definition
Slow enzyme with all 3 polymerase activities; removes RNA primer & repairs DNA; Prokaryotic
Term
DNA Polymerase III
Definition
High processivity; replicates most DNA; lacks 5'-3' exonuclease activity & can't remove RNA primer; Prokaryotic
Term
RNA Polymerase
Definition
4 subunits: 2x alpha, beta, beta'; sigma cofactor binds & increases affinity for promoter; beta subunit makes 1st phosphodiester bond; Prokaryotic
Term
RNA Polymerase I
Definition
rRNA; Eukaryotic
Term
RNA Polymerase II
Definition
mRNA; has CTD; alpha-amantin inhibits; Eukaryotic
Term
RNA Polymerase III
Definition
tRNA; Eukaryotic
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