Term
|
Definition
Haldol
first generation
high potency
Category C
long-acting injection |
|
|
Term
|
Definition
Thorazine
first generation
low potency
SE: deposits in lens and cornea, blue-grey skin discoloration
Category C |
|
|
Term
|
Definition
Zyprexa
second generation
SE: metabolic syndrome, liver toxicity (monitor LFTs), orthostatics |
|
|
Term
|
Definition
Risperdal
second generation
most like first generation |
|
|
Term
|
Definition
Clozail
second generation
SE: agranulocytosis (weekly CBCs), seizures, hypotension |
|
|
Term
|
Definition
Prolixin
first generation
high potency
long-acting injection |
|
|
Term
|
Definition
Seroquel
second generation
SE: orthostasis, sedation, cataracts in beagle dogs (slip lamp exams) |
|
|
Term
|
Definition
Geodone
second generation
no metabolic syndrome |
|
|
Term
|
Definition
Abilify
second generation
SE: partial DA agonist --> psychotic decompensation
no metabolic syndrome |
|
|
Term
|
Definition
MAOI
SE: HTN crisis --> dietary restriction, no tyramine (red wine, cheese, chicken liver, fava beans, cured meats) or sympathomimetics |
|
|
Term
|
Definition
MAOI
SE: HTN crisis --> dietary restriction, no tyramine (red wine, cheese, chicken liver, fava beans, cured meats) or sympathomimetics |
|
|
Term
|
Definition
selective MAOI (B>A)
SE: HTN crisis --> dietary restriction, no tyramine (red wine, cheese, chicken liver, fava beans, cured meats) or sympathomimetics
daily patch!! |
|
|
Term
|
Definition
TCA -- serotonin AND norepinephrine
SE: cardiac toxicity (torsades) in OD, anti-histamine, anti-cholinergic, and anti-adrenergic effects --> poorly tolerated |
|
|
Term
|
Definition
TCA -- tertiary amine -- serotonin
SE: cardiac toxicity (torsades) in OD, anti-histamine, anti-cholinergic, and anti-adrenergic effects --> poorly tolerated
first/second line for OCD!! |
|
|
Term
|
Definition
TCA -- tertiary amine -- serotonin
SE: cardiac toxicity (torsades) in OD, anti-histamine, anti-cholinergic, and anti-adrenergic effects --> poorly tolerated |
|
|
Term
|
Definition
TCA -- secondary amine -- norepi
SE: cardiac toxicity (torsades) in OD, anti-histamine, anti-cholinergic, and anti-adrenergic effects --> poorly tolerated
least likely to have hypotension |
|
|
Term
|
Definition
Effexor
<150 serotonin
150-300 norepinephrine
>300 dopamine??
SE: idiopathic HTN
lowest protein bound profile!! |
|
|
Term
|
Definition
Cymbalta
SNRI
SE: idiopathic HTN, avoid in liver injury patients!!
neuropathic pain |
|
|
Term
|
Definition
Paxil
SSRI
SE: sexual dysfunction, GI upset, sleep disturbance, less activation!!, BAD withdrawal!! |
|
|
Term
|
Definition
Celexa
SSRI
SE: sexual dysfunction, GI upset, sleep disturbance, decreased drug interactions!!, high doses (>40) lengthen QT interval!! |
|
|
Term
|
Definition
Lexapro
SSRI
SE: sexual dysfunction, GI upset, sleep disturbance, decreased drug interactions!! |
|
|
Term
|
Definition
Prozac
SSRI
SE: sexual dysfunction, GI upset, sleep disturbance, longest half-life!!, more activating!! |
|
|
Term
|
Definition
Luvox
SSRI
SE: sexual dysfunction, GI upset, sleep disturbance, hepatic failure!! |
|
|
Term
|
Definition
Zoloft
SSRI
SE: sexual dysfunction, GI upset!!, sleep disturbance |
|
|
Term
|
Definition
Wellbutrin, Zyban
NDRI
no sexual dysfunction
SE: seizures (not if hx of epilepsy, eating disorders, chronic diarrhea), don't take too late b/c NE, increase anxiety, increase psychosis |
|
|
Term
|
Definition
Remeron
NASA (alpha2 antagonist)
no sexual dysfunction
SE: more sedation at lower doses, weight gain |
|
|
Term
|
Definition
SARI - serotonin and NE??
SE: sedating, priapism!! |
|
|
Term
|
Definition
SARI - serotonin and NE??
SE: hepatic failure
no sexual dysfunction |
|
|
Term
|
Definition
mood stabilizer
SE: kidney (DI), heart (sick sinus syndrome), thyroid (hypo>hyper), Ebstein's anomaly (heart); weight gain, tremor, GI, fatigue, arrhythmias, seizures, goiter/hypothyroidism, benign leukocytosis, coma, polyuria, polydipsia, alopecia, metallic taste
Category D |
|
|
Term
|
Definition
Tegretol
mood stabilizer
SE: skin (Steven-Johnson's), blood (leukopenia, aplastic anemia, or agranulocytosis), liver, hyponatremia, induces own metabolis, craniofacial defects |
|
|
Term
|
Definition
Depakene/Depakote
mood stabilizer
SE: liver, blood (thrombocytopenia or agranulocytosis), pancreas, neural tube defects
Category X!! |
|
|
Term
|
Definition
Lamictal
SE: skin (Steven-Johnson's) |
|
|
Term
|
Definition
Xanax
glucuronidation AND oxidation
quick onset, short duration
SE: rebound anxiety |
|
|
Term
|
Definition
Ativan
glucuronidation ONLY
long onset, average duration |
|
|
Term
|
Definition
Klonipin
glucuronidation AND oxidation
long onset, longer duration |
|
|
Term
|
Definition
Serax
glucuronidation ONLY |
|
|
Term
|
Definition
partial agonist of 5-HT1a
usually doesn't work if used to benzos
1-2 wks to take effect |
|
|
Term
|
Definition
Nucleus Basalis of Meynert
decreased in cognitive disorders |
|
|
Term
|
Definition
Ventral Tegmental Area
decreased in depression
increased in psychosis |
|
|
Term
|
Definition
Locus Cereleus
decreased in depression
increased in anxiety |
|
|
Term
|
Definition
Raphe Nuclei
decreased in depression |
|
|
Term
| high potency vs. low potency anti-psychotics |
|
Definition
low potency anti-psychotics have...
more anti-histamine effects
more anti-adrenergic effects
more anti-cholinergic effects
less extrapyramindal SEs
less NMS |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
delirium
blurry vision
xerostomia (dry mouth)
constipation
urinary retention |
|
|
Term
|
Definition
Mellaril
first generation
low potency
SE: irreversible retinal pigmentation |
|
|
Term
|
Definition
Stelazine
first generation
high potency |
|
|
Term
|
Definition
Trilafon
first generation
high potency |
|
|
Term
|
Definition
Orap
first generation
high potency |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
TCA -- secondary amine -- norepi
SE: cardiac toxicity (torsades) in OD, anti-histamine, anti-cholinergic, and anti-adrenergic effects --> poorly tolerated
least anti-ACh, least sedation |
|
|
Term
|
Definition
TCA -- secondary amine -- norepi
SE: cardiac toxicity (torsades) in OD, anti-histamine, anti-cholinergic, and anti-adrenergic effects --> poorly tolerated |
|
|
Term
|
Definition
NRI
UK only
SE: tremor, tachycardia |
|
|
Term
|
Definition
Straterra
marked to adult ADD --> off label for refractory depression
SE: tremor, tachycardia |
|
|
Term
|
Definition
TCA -- serotonin AND norepinephrine
SE: cardiac toxicity (torsades) in OD, anti-histamine and anti-cholinergic effects --> poorly tolerated |
|
|
Term
|
Definition
TCA -- serotonin AND norepinephrine
SE: cardiac toxicity (torsades) in OD, anti-histamine and anti-cholinergic effects --> poorly tolerated |
|
|
Term
|
Definition
MAOI
SE: HTN crisis --> dietary restriction, no tyramine (red wine, cheese, chicken liver, fava beans, cured meats) |
|
|
Term
|
Definition
MAOI
reversible!! --> no dietary restrictions |
|
|
Term
|
Definition
TCA
SE: cardiac toxicity (torsades) in OD, anti-histamine, anti-cholinergic, and anti-adrenergic effects --> poorly tolerated |
|
|
Term
|
Definition
Ambien
SE: dissociation-like states (sleepwalking, binge-eating, aggressive outbursts, night driving) |
|
|
Term
|
Definition
Sonata
SE: dissociation-like states (sleepwalking, binge-eating, aggressive outbursts, night driving) |
|
|
Term
|
Definition
mimics melatonin
SE: HA
do NOT prescribe if... severe hepatic impairment, sleep apnea, or COPD |
|
|
