Term
scopolamine
ANTIDOTE: physostigmine (blocks AChE thus increasing ACh) |
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Definition
-anticholinergic psychedelic (antimuscarinic)
-other common anticholinergics= atropine and l-hyoscyamine
-found in travel-sickness products
**acts on PNS =dry mouth, reduced sweating, dry skin, higher body temp, pupil dilation, blurry vision... CLOUDS CONSCIOUSNESS AND PRODUCES AMNESIA!!! |
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Term
| mescaline (peyote cactus) found in S.W. U.S. and Mexico |
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Definition
-indians
-orally - rapidly and completely absorbed (5mg/BW)
-reaction takes 1-2 hrs
-produces acute psychotomimetic state and high effects on visuals within 3.5-4
-lasts 10hrs and does not metabolize before excretion |
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Term
MDMA (ecstasy) aka catecholamine psychedelic
structurally related to mescaline & methamphetamine
-more potent than mescaline |
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Definition
-reuptake inhibitor of monoamines 5-HT, DA, and NE & ACh
- adverse reactions=higher BP, HR, muscle tension & anxiety
-breakdown of skeletal muscle, hyperthermia, kidney failure etc
-rapid tolerance is developed
HIPPOCAMPAL DAMAGE!!! |
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Term
| other MDMA related substances |
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Definition
2,5 dimethoxy-4-propylthiophenethylamine aka BLUE MYSTIC
2C-T-7, T7, Tripstay, Tweety Bird Mescaline, 2C-b, Nexus, etc
-PIPERAZINES: BZP or TFMPP |
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Term
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Definition
-derived from nutmeg & mace
-1-2 tbsp or 5-15 grams often via brewed tea
-2-5 hr delay
-induces confusion, unreality, disorientation, depersonalization, hallucinations, and euphoria
-side effects=vomiting, nausea, and tremors. death=infrequent |
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Term
| LSD (Lysergic Acid diethylamide) |
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Definition
-Albert Hofmann 1938
-orally & rapid absorption
-25-300 micrograms w/60min absorption
-metabolized in liver b4 excretion within 6-8 hrs
-present in urine up to 30hrs post ingestion
-somatic phase=CNS activation
-easy cross- tolerance |
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Term
Phencycladine & Ketamine
(Glutaminergic NDMA Receptor Antagonists) |
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Definition
psychotomimetic alnalgesic amnestic actions of NMDA noncompetitive antagonists thus they inhibit NMDA recep by blockage of ACh recep, DA reuptake, induce DA release, and partial agonist at DA2receptors
-high doses=coma or stupor
-PCP aka angel dust
-sold in crystal, dust, hog, PCP, THC, or mescaline
-eaten, snorted, or injected IM/IV
-oral=slow absorp. smoked=15min peak max-2hrs half life=18hrs (11-51hrs)
lethal dose=10x the anesthetic dose & reduces pain, maintains BP & HR
special K
not taken orally bc metab. by norketamine
used in pediactrics & vet anesthesia
rapid antidepressant effects & induce syptoms of schizophrenia
**structurally unrelaed to other psychedelics |
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Term
methoxetamine
(ketamine family) |
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Definition
noncompetitive antagonist for NMDA receptor w/ DA reuptake
-orally [20-100mg], rectally, snorted, injected(IM)[10-50mg]
effects after 5-10min, lasts 1-2hrs...5-7 snorting
-euphoria, hallucinations, poiate-like effects
-adverse reactions= nausea, vomiting, diarrhea, paranoia, anxiety, tachycardia, respiratory depression
-care=benzodiazepenes and antimimetics |
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Term
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Definition
-OTC cough suppresants ie Robitussin DM, Vicks, Tylenol DM..
-blocks NDMA receptors
-metabolite=dextrophan (DXO)
-raises BP, HR, creates jitters, anxiety, takativeness, and somatic effets like dizziness numbness etc.
-max dose=unresponsiveness, confusion, fearfulness, or mysticism |
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Term
Salvinorin A
(Salvia Divinorum aka magic mint, diviner's sage, Sally-D) |
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Definition
-perennial herb used to cure divination in spritual practice
-chewed, smoked[200-500 micrograms], or brewed in tea
-short acting=about 30 min & legal
*endures 1st pass metabolism and breakdown
-laughter, realm of dead, feeling whole, flying floating sensations, etc..
-adverse effects= confusion, drwosiness, intense anxiety, hangover headache...
-no action on serotonin 5-HT2A receptors but a kappa opiod agonist
-can be used to treat GI disorders |
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Term
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Definition
-derived from morning glory seeds in Central & S. Amer.
-nausea, headache, vomiting, raises BP, dilates pupils and induces sleepiness
100+ seeds leads to distorted perception, hallucinatons, and confusion |
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Term
Bufotenine
(5-hydroxy DMT aka dimethylserotonin) |
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Definition
-acts like LSD and DMT
-potent serotonin agonist hallucinogen especially 5-HT2A recpetor |
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