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Rate-Determining Enzymes
Biochem
13
Medical
Graduate
03/30/2013

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Cards

Term
Glycolysis
Definition
Phosphofructokinase-1
+ AMP, F26BP
- ATP, citrate
Term
Gluconeogenesis
Definition
Fructose-1,6-bisphosphatase
+ ATP
- AMP, F26BP
Term
TCA cycle
Definition
Isocitrate dehydrogenase
+ ADP
- ATP, NADH
Term
Glycogen synthesis
Definition
Glycogen synthase
+ glucose, insulin
- epinephrine, glucagon
Term
Glycogenolysis
Definition
Glycogen phosphorylase
+ AMP, epinephrine, glucagon
- insulin, ATP
Term
HMP shunt
Definition
G6PD
+ NADP+
- NADPH
Term
De novo pyrimidine synthesis
Definition
Carbamoyl phosphate synthetase II
Term
De novo purine synthesis
Definition
Glutamine-PRPP amidotransferase
- AMP, IMP, GMP
Term
Urea cycle
Definition
Carbamoyl phosphate synthestase I
+ N-acetylglutamate
Term
Fatty acid synthesis
Definition
Acetyl-CoA carboxylase (ACC)
+ insulin, citrate
- glucagon, palmitoyl-CoA
Term
Fatty acid oxidation
Definition
Carnitine acyltransferase I
- malonyl-CoA
Term
Ketogenesis
Definition
HMG-CoA synthase
Term
Cholesterol synthesis
Definition
HMG-CoA reductase
+ insulin, thyroxine
- glucagon, cholesterol
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