• 30-50 yrs
• Subepithelial ICs
• Nephrotic
• LM:  -
• IF:  IgG, C3
• EM: Subepithelial "spikes and domes"

• Kids, adults, Blacks
• HIV, heroin, sickle cell
• Nonselective proteinuria (NEPHROTIC
• LM: focal, collapse of GBM
• IF: IgM, C3
• EM: loss of foot processes,
• Poor response to steroids, 50% --> ESRD

• 30-50
• Subepithelial IC accum: C5b-C9 mediated
• NEPHROTIC
• 50% spont. remission, 20% ESRD
• LM: Thickening of capillary loops, looks almost norm
• IF: IgG, C3
• EM: spikes and bumps

• SLE lesion, endocarditis, infection...
• NEPHRITIC
• CHECK THIS ONE

• Older kids and adults
• TYPE I: classical, alternative paths, subendo deposit
• TYPE II: alt path only, "ribbon-like" dep IN GBM
• NEPHRITIC
• LM - Lobular, tram-track, messangial matrix ↑
• IF: (I): IgG, C3       (2) C3 w/in GBM (nephritic fact)
• EM: double-contour BM

DIABETIC

GLOMERULOSCLEROSIS

• #1 cause of ESRD in USA
• Microalbunemia --> ESRD due to HT
• LM: large glomeruli, messangial wid'ng, NODULES (Kimmel-wilson), GBM thickening Hyaline sclerosis of efferent arteriole
• IF -
• EM: GBM thickening, messangial matrix ↑

• Kidney most common site for deposiiton
• Protenuria --> nephrotic--> ESRD
• Histo: congo red in glomeruli, BV

AcuteProliferative

(Poststreptococcal, Postinfectious) GN

• 6-10 yrs, can affect adults
• NEPHRITIC
• Type 2 hpersensitivity, IC's dep. in gloms
• History of recent strep, infection 1-4 weeks prior
• Increased ASO titers, ↓ blood C3
• M- tufts ↑cellularity, endothelial messangial cells swell and prolif, MN, monocytes, RED CASTS
• IF - IgM, IgG, C3 along GBM and messangium
• EM - Scattered subepithelial humps