Term
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Definition
5α-reductase inhibitor
Mech: prevents reduction of T to DHT; incr. T (promotes hair growth)
Use: BPH; male-pattern baldness
Tox: gynecomastia (BPH) |
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Term
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Definition
Nonsteroidal competitive androgen receptor antag
Use: prostate CA |
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Definition
Antifungal/steroid synthesis inhibitor (androgen>estrogen)
Use: prevention of hirsutism in PCOS
Tox: gynecomastia, amenorrhea |
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Term
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Definition
K-sparing diuretic/inhibits steroid binding (androgen>estrogen)
Use: prevention of hirsutism in PCOS
Tox: gynecomastia, amenorrhea |
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Definition
GnRH analog
Mech: agonist when pulsitile; antag when continuous
Use: infert (pulse), prostate CA (cont. + flutamide), uterine fibroids
Tox: antiandrogen, n/v
Note: when continuous, 1st transient incr., then decr. in both T & DHT |
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Term
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Definition
PDE-5 inhibitor (others: vardenafil)
Mech: inhib cGMP degr. → sm. m. relax → incr. blood flow/erection
Use: EDTox: h/a, flushing, blue-green colorblindness
Interact: life-threat hypoTN in combo w/ nitrates |
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Term
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Definition
Competitive progesterone R antag (AKA: RU-486)
Use: combo w/ misoprostol (PGE1) for abortion
Tox: heavy bleeding, GI, abd pn |
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Term
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Definition
Synthetic progestins + estr
Mech: prevent LH & FSH synth → LH surge → no ovulation; also decr. fallopian tube motility, makes cerv. mucus hostile, & decr. implantation
Tox: incr. TGs, depression, wt. gain, nausea, HTN, hypercoag; incr. risk breast CA
Notes: decr. risk endometrial/ovarian CA, ectopic preg, & pelvic infxnsAbsolute contra: 1) prior thromb/stroke, 2) estr-dep CA, 3) smokers >35, 4) high TG, 5) liver dz, 6) preg |
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Term
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Definition
Use: relief of menopause sx & osteoporosis
Tox: incr. risk endometrial CA w/o progesterone; possible incr. CV risk |
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Term
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Definition
PGE2 analog
Mech: cervical dilation & uterine contract.
Use: induce labor |
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Term
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Definition
β2 Ag
Mech: relax uterus, reduce premature uterine contractions |
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Definition
β2 Ag
Mech: relax uterus, reduce premature uterine contractions |
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Definition
Aromatase inhibitor
Mech: prevent T => estr
Use: postmenopausal breast CA |
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Term
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Definition
Aromatase inhibitor (irrev)
Mech: prevent T => estr
Use: postmenopausal breast CA |
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Term
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Definition
Estrogen (others: DES, ethinyl estradiol)
Mech: binds estr Rs
Use: hypogonadism, ovarian failure, HRT; androgen-dep prostate CA (men)
Tox: endometrial CA, clear cell vaginal AdCA (DES in utero), thrombiContra: ER+ breast CA |
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Term
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Definition
Mech: bind prog.
RsMech: decr. growth & incr. vascularization of endometrium
Use: OCPs, endometrial CA, abnl uterine bleeding |
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Term
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Definition
SERM - estr partial ag
Mech: binds estr Rs in HT → prevents neg f.b. → incr. LH & FSH release → ovulation
Use: infertility, PCOS
Tox: hot flashes, ovarian enlargment, simultaneous pregnancies, visual disturb. |
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Term
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Definition
SERM - estr partial ag
Mech: antagonizes breast tissue
Use: ER+ breast CA |
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Term
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Definition
SERM - estr partial ag
Mech: agonist on bone → decr. resorptionUse: osteoporosis |
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Term
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Definition
Herb
Mech: vasodil of vessels
Use: ED |
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