Term
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Definition
5a-reductase inhibitor (decrease conversion to DHT)
used in BPH, hair growth (male pattern baldness) |
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Term
| A nonsteroidal competitive inhibitor of androgens at Te receptor |
|
Definition
Flutamide
used in prostate carcinoma |
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Term
| Inhibits steroid synthesis, used in PCOS |
|
Definition
Ketoconazole (prevents hirsuitism in PCOS)
SE: gynecomastia, amenorrhea |
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Term
| Inhibits steroid binding, used in PCOS |
|
Definition
spironolactone
SE: gynecomastia, amenorrhea |
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Term
|
Definition
Finasteride
Flutamide
Ketoconazole
Spironolactone |
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Term
|
Definition
Leuprolide
agonist: pulsatile
antagonist: continuous |
|
|
Term
| Prostate cancer treatment |
|
Definition
flutamide: nonsteroidal competitive inhibitor of androgens at Te receptor
Leuprolide: GnRH analog, continuous fashion |
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|
Term
| Treatment for uterine fibroids |
|
Definition
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Term
|
Definition
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Term
| Inhibit cGMP phosphodiesterase, increases cGMP and causes smooth muscle relaxation |
|
Definition
Sildenafil, vardenafil
relaxation in the corpus cavernosum, increases blood flow and penile erection |
|
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Term
|
Definition
HA, flushing, dyspepsia, impaired blue-green color vision
risk of life threatening hypotension in patients taking nitrates |
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Term
| Competitive inhibitor of progestins at progesterone receptors |
|
Definition
Mifepristone (RU-486)
terminates pregnancy, given with misoprostol (PGE1) |
|
|
Term
| SE: mifepristone (RU-486) |
|
Definition
heavy bleeding
GI effects (N/V/A)
abdominal pains |
|
|
Term
| Impaired blue green vision |
|
Definition
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Term
|
Definition
| prevent estrogen surge, LH surge doesn't occur, ovulation doesn't occur |
|
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Term
|
Definition
endometrial and ovarian cancer
ectopic pregnancy
pelvic infections |
|
|
Term
|
Definition
increase triglycerides
hypercoaguable state |
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Term
|
Definition
menopausal symptoms
osteoperosis |
|
|
Term
| Unopposed estrogen replacement therapy increase risk of? |
|
Definition
endometrial cancer
this is why progesterone is added to HRT
possible increased CV risk |
|
|
Term
| PGE2 analog causing cervical dilation and uterine contraction |
|
Definition
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|
Term
| B2 agonist that relaxes the uterus |
|
Definition
Ritodine/terbutaline
reduces premature uterine contractions |
|
|
Term
| Aromatase inhibitors used in postmenopausal women with breast cancer |
|
Definition
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|
Term
|
Definition
hypogonadism
development of secondary sex characteristics
stimulate anabolism to promote recovery after burn/injury
treat ER-positive breast CA (exemestane) |
|
|
Term
|
Definition
Females: masculinization
Males: decrease intratesticular Te by inhibiting leydig cells, gonadal atrophy
premature closure of epiphyseal plates
decrease HDL, increase LDL |
|
|
Term
| Use in men with androgen dependent prostate cancer |
|
Definition
|
|
Term
| Clear cell adenocarcinoma of vagina in exposed females |
|
Definition
|
|
Term
| Contraindications to estrogen |
|
Definition
|
|
Term
| Bind progesterone receptors |
|
Definition
Progestins
reduce growth and increase vascularization of endometrium |
|
|
Term
| Used to treat endometrial cancer and abnormal uterine bleeding |
|
Definition
|
|
Term
| Partial agonist at estrogen receptor in pituitary gland |
|
Definition
Clomiphene
prevents normal feedback inhibition, increases release of LH and FSH, stimulating ovulation
treats infertility and PCOS |
|
|
Term
|
Definition
partial agonist at estrogen receptors in pituitary gland
hot flashes, ovarian enlargement, multiple simultaneous pregnancies, visual disturbances |
|
|
Term
| Antagonist on breast tissue |
|
Definition
Tamoxifen
used to treat and prevent reoccurrence of ER-positive breast cancer |
|
|
Term
| Estrogen partial agonist on bone |
|
Definition
Raloxifene
reduces resorption of bone, used to treat osteoperosis |
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