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Resistance mechanisms for antibiotics
For Step 1
8
Medical
Graduate
06/01/2010

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Term
MoR for penicillin
Definition
Beta lactamse cleavage, alterered PBP (MRSA and penicillin resistant S. pneumo)
Term
MoR for aminoglycoside
Definition
Modification via acetylation, adenylation, phosphorylation
Term
MoR for vanco
Definition
Terminal D-ala replaced with D-lac
Term
MoR for chloramphenicol
Definition
Modification via acetylation
Term
MoR for macrolides
Definition
Methylation of rRNA near erythromycin's ribosome-binding site
Term
MoR for tetracycline
Definition
Decreased uptake and increased export
Term
Sulfonamides
Definition
Altered dihydropteroate synthetase, decreased uptake or increased PABA synthesis
Term
Quinolones
Definition
Altered gyrase or reduced uptake
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