Term
| chlorpromazine (thorazine) |
|
Definition
-phenothiazine
-aliphatic
-a1, 5-ht2, D2, d1, M1, h1
-many side effects (orthostatic hypotension, anticholinergic SE)
-1st antipsychotic, big impact on schiz |
|
|
Term
|
Definition
-phenothiazine
-piperdine
-higher pot than chlorpormazine, higher incidence of EPS
-A1, 5-ht2, D2, M1, h1
-prolongs QT interval (cardiotoxicity) |
|
|
Term
|
Definition
-phenothiazine
-piperazine
-higher clinical potency
-D2, a1, 5-ht2
-IM inj every 2 wks is common in clinic
-sesame oil is vehicle |
|
|
Term
| trifluperazine (stelazine) |
|
Definition
-phenothiazine
-piperazine
-high clinical potency
-highest incidence of EPS of phenothiazines |
|
|
Term
| prochlorperazine (compazine) |
|
Definition
-phenothiazine
-used as antiemetic
-not for psychosis but can cause tardive dyskinesia if used long term
-treatment of vertigo by blocking D2 Rs in CTZ |
|
|
Term
|
Definition
-butyrophenones
-derived from meperidine
-more potent than phenothiazines
-d2>d1=d4>a1>5-ht2
-EPS more common
-IM every 4 wks, sesame oil vehicle |
|
|
