Term
Lymphoid tissue affected
Reed Sternberg cells (giant cells)
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Definition
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Term
Affects lymphoid tissues
Epstein-Barr Virus involved in one version of this disease |
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Definition
NON-HODGKIN'S LYMPHOMA
(Burkitt's lymphoma is the one with the EBVmarkers on all tumor cells) |
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Term
Bence-jones protiens
(light chain protiens)
seen in urine
Overproduction of monoclonal (M) protein
and/or
free light chains |
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Definition
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Term
Usually B-cell neoplasm
Sometimes T cell as well
Ig SERUM LEVELS DECREASED
--> multiple bacterial infections |
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Definition
Chronic Lymphocytic Leukemia
(CLL) |
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Term
Increase in NEUTROPHILS
Philadelphia chromosome
Translocation of chromosomes 9,22
--->
New chrom. 22 encoces BCR-ABL protien
(a tyrosine kinase) |
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Definition
Chronic Myeloid Leukemia
(CML) |
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Term
INHERITED
immune disorder |
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Definition
PRIMARY
immune disorder
deficits of components in
B, T, phagocytes, compliment |
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Term
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Definition
SECONDARY
immune disorders
(due to drugs, lifestyle, viruses such as HIV, abnormal Ab production...) |
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Term
Defect in gene encoding a tyrosine kinase
no pre-B to mature B maturation
No IgA, IgM
Very low IgG |
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Definition
X-linked ("Bruton's) Agammalobulinemia |
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Term
Caucasians
Low IgA levels
RECURRENT SINOPULMONARY infecions |
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Definition
Selective IgA defficiency
(Can't give IgG, because won't get throug mucous membranes(no secretory component like IgA to protect it in transit)
Can't give IgA--> Anti-IgA Ab's formed |
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Term
deficiency in CD40L
(on T cells) |
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Definition
Immunoglobulin deficiency
with
Increased IgM
Lack of isotype switching
Severe bacterial infections |
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Term
Congenital thymic hypoplasia
(defect on chromosome 22) |
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Definition
DeiGeorge's syndrome
No T cells
B-cell activity compromised
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Term
Defect in Adenosine Deaminase (ADA)
or
Jak3 in IL-2 receptor |
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Definition
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Term
Increased bacterial deficiency
C1, C2, or C4 deficiency |
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Definition
| Inactive classical complement pathway |
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Term
| Recurrent neisserial infections |
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Definition
Can't make MAC
C5-C9 deficiency |
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Term
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Definition
titration of patient's serum with RBCs (opsonised) that results in hemolysis of 50% of RBCs
(AH50 used to test alternative path) |
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Term
Defect in
(glyco) phosphatidyinositol (GPI) linkage
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Definition
Paroxysmal Nocturnal Hemoglobinuria
(PNH)
DAF and CD59 can't bind |
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Term
| Defect in C1 esterase inhibitor |
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Definition
Heriditary Angioedema
(HAE)
uncontrolled activation of C1 and classical path |
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Term
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Definition
Leukocyte Adhesion Deficiency
(LAD) |
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Term
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Definition
| Chronic granulomatous disease |
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Term
Giant cytoplasmic granules
Inability of NK cells to release granules
susceptibility to bacteria, fungi, viruses
disfunctional neutrophils |
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Definition
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Term
Injection of
Purified Protien Derivative (PPD) from M. tuberculosis |
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Definition
Mantoux test for TB
If prior exposure, will have memory Th1 cells which will recognize Class II MHC peptide and secrete type 1 cytokines which fuel inflammation |
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Term
| Disease prevents fusion of lysosomes to the phagosome |
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Definition
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Term
Cutaneous exposure to
urishiol |
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Definition
Contact Dermatitis
(poision oak hapten) |
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Term
What is RAST testing used for ? |
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Definition
Looks for allergen-specific IgE in serum
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Term
Antibodies formed to Intrinsic factor or parietal cells |
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Definition
Pernicious anemia
(no B-12 absorption)
--> Megalobastic anemia |
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Term
Antibodies to
Glycophorin or Ii
(cell surface antigens) |
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Definition
Cold Agglutin Disease
Seen at temps below 37C, see at extremeties
(nose, fingers, toes) |
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Term
Anti-DNA Antibodies
Anti phospholipid
Anti nuclear
Anti-leukocyte
Polyclonal B-cell activation
Systemic and multiorgan disease |
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Definition
Systematic Lupus Erthematosus
(SLE) |
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Term
Excessive Type 1 cytokines
Rheumatoid factors
(not essenial)
Neutrophils in joints |
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Definition
Rheumatoid Arthritis
(Eitology unknown) |
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Term
CNS
Antibodies to Myelin Basic Protien
(MBP)
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Definition
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Term
Antibodies to
THYROGLOBULN |
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Definition
Hashimoto's Thyroiditis
(Manifests as goiter/hypothyroidism |
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Term
Increase in eosinophils
Antibodies to p-anca |
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Definition
Churg-Strauss Vascularitis
(asthmatic sumptoms) |
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Term
Infects Lungs and Kidneys
Anti-GBM antibodies
LINEAR deosition of IgG and complement
Males 8X females |
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Definition
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Term
Antibodies to TSH Receptors |
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Definition
Grave's disease
Unregulated secretion of T3, T4
(hyperthyroidism) |
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Term
Antibodies to Ach receptors |
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Definition
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Term
Afects joints
May occur after infection with Klebsiella pneumoniae
NO rheumatoid factor |
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Definition
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Term
Lack of all Ig's
Immature B cells
lack of development from immature to mature B's
M=F |
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Definition
| Common Variable Hypogammaglobulinemia |
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Term
Lack of CD40/CD40L interaction |
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Definition
Ig Deficiency with increased IgM |
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Term
Low T3, T4
Anti-thyroglobulin, Anti-microsomal antibodies
(microsomes are vesicles formed in the ER when cells are disrupted_ |
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Definition
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Term
AGGLUTINATION TEST
Is a positive result seen with
Agglutination or no agglutination??
(See Jackie book pg. 212) |
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Definition
NO agglutination.
Antibodies in test kit are bound to antigens in patient's serum, so don't agglutinate when antigen-coated particles are added to the solution |
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Term
What is the
PROZONE PHENOMENON
? |
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Definition
Too much ANTIBODY
in a precipitation test results in
VERY LITTLE AGGLUTINATION |
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Term
What is the
POST ZONE
phenomenon? |
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Definition
Too much
ANTIGEN
in a precipitation reaction
resulting in less precipitation than
in equivalence zone |
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