Term
|
Definition
dsDNA
icosahedral, enveloped, intranuclear
inclusion bodies
multinucleated giant cells (syncytia)
Tzank smear - genital herpes (old ID) |
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Term
| Herpesviruses Group Members |
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Definition
Neurotropic - within neurons
HSV 1 and 2, VZV
Lymphotropic - w/i nucleus of T/B cells
EBV, CMV, HHV6(roseola), HHV7, HHV8/KSHV |
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Term
| Hallmarks of Herpesviruses |
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Definition
lifelong infection, latency
HSV 1,2 & VZV can reactivate to cause recurrent disease
CMV, EBV reactivate due to immunosupression
tethered - "extracromosomal" DNA
latency assoc. RNA transcription
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Term
| Herpes Simplex Virus Type 1 |
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Definition
Gingivostomatitis - mouth primary infection, children
herpes labialis - "cold sores" (adolescence,adult)
keratoconjunctivitis
eczema herpeticum |
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Term
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Definition
| meningitis, encephalitis, can be recurrent, can follow skin, oral, genital, ocular infection |
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Term
|
Definition
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Term
|
Definition
| health care professionals |
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Term
|
Definition
"drug eruption"
follows allergic RX
"target" lesions |
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Term
Erythema Multiforme
Pathogenesis |
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Definition
recurrent or sublinical ->
HSV DNA fragments + macrophage/monocytes ->
DNA exp. in keratinocytes + CD4 Tcells attracted to HSV antigen -> SKIN -> Interferons, cytokines, chemokines - > DTH
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Term
|
Definition
Usually acquired in childhood
passage primarily via asymptomatics
immune system controls symptoms but can not get rid of virus |
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Term
| Varicellas Zoster Virus (VZV) |
|
Definition
URI -> primary viremia ->
secondary viremia -> capillaries to skin -> lesions |
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Term
|
Definition
primary infection in children
invade sensory neuron become dormant
CONCERN: scratch -> infection
fluid filled vesicles
multinucleated giant cells |
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Term
|
Definition
reactivation of latent virus, adults
*Post herpetic neuralgia
Immunocompetent = myelitis, large granulomatous arteritis
Immunocompromised = myelitis, sm. vessel encephalitis |
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Term
|
Definition
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Term
|
Definition
| vesicles, pustules, crusts, ulcers |
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Term
|
Definition
| Respiratory droplets, contact with lesions |
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Term
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Definition
Roseola (6th Disease, exanthem subitum)
T/B cells
fever/rash
seizures, encephalitis |
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Term
|
Definition
| Roseola - less common than HHV6 |
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Term
|
Definition
Kaposi's sarcoma, orally, STI, vasc endothelial, spindle cells, lymph nodes
B cell lymphomas
immuno suppressed |
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Term
|
Definition
Clinical symptoms
virus isolation, ID, rise in AB titer
CF, neutralization, ELISA, PCR, immunoblot |
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Term
|
Definition
PREVENTION:
ALL inhibit viral DNA polymerase |
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Term
Acyclovir (Zovirax)
prodrugs |
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Definition
valacyclovir (Valtrex)
famciclovir (Famvir)
penciclovir (Denavir)
Primary value is decrease of morbidity/mortality in: encephalitis, neonatal, and immunocompromised HSV/chickenpox |
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
| Vaccine for VZV (chickenpox) |
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Term
|
Definition
| elderly formula vaccine to prevent zoster |
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Term
|
Definition
| varicella zoster immune globulin - for serious complications |
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Term
|
Definition
ds DNA complex
surrounded by membrane
nucleoid
largest physically/genetically
9 different |
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Term
|
Definition
variola virus - only infectious agent eradicated
vaccine = vaccinia virus |
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Term
| Small pox - Clinical characteristics |
|
Definition
human specific
spread by inhalation
12-14d incubation
3 d flu like start of infection period
17 d rash
30% mortality
NO TX |
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Term
|
Definition
common pox virus infection
primarily children, communicable - direct contact, fomites ,sexual |
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Term
|
Definition
common pox virus infection
farmers (sheep/goats) |
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Term
|
Definition
common pox virus infection
paraviccinia virus
dairy farmers, butchers |
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