Term
| unspecialized cells capable of renewing themselves through cell division. sometimes after long periods of inactivity |
|
Definition
|
|
Term
| Can be induced to become tissue- or organ-specific cells with special functions |
|
Definition
|
|
Term
| self-renew in cultures; can be induced to differentiate in culture or in vivo into ectoderm, mesoderm, and endoderm |
|
Definition
|
|
Term
| self-renew in the bone marrow; produce the entire blood system |
|
Definition
|
|
Term
| germline-derived stem cells |
|
Definition
| spermatogonial stem cells; oogonial stem cells |
|
|
Term
| examples of common molecular processes that underly self-renewal |
|
Definition
|
|
Term
| distinct stem cell types have some common characteristics |
|
Definition
| have the capacity to sense a broad range of growth factors and signaling molecules; express downstream signaling components to respond to these signals; express many genes involved in regulating cell cycle and quiescence |
|
|
Term
| the ability of a single cell to divide and produce all the differentiated cells in an organisms, including extraembryonic tissues |
|
Definition
|
|
Term
| a stem cell that has the potential to differentiate into any of the three germ layers |
|
Definition
|
|
Term
| have the potential to give rise to cells from multiple lineages |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| also called colongy forming units (CFU) when plated in semi-solid medium; often confused with stem cell |
|
Definition
| hematopoietic progenitors |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| concept of blood forming stem cells was developed |
|
|
Term
|
Definition
| bone marrow extract is given orally as a treatment for leukemia |
|
|
Term
|
Definition
| Jacobson et al. found that mice would survive otherwise lethal irradiation if the spleen was protected by lead |
|
|
Term
|
Definition
| Lorenz et al. showed that infusion of bone marrow cells could also protect mice from irradiation |
|
|
Term
|
Definition
| became evident that marrow transplantation could be used therapeutically (marrow aplasia, leukemia, genetic hematopoietic/immune diseases (SCID-X1) |
|
|
