Term
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Definition
rate of elimination/plasma drug concentration
OR
Vd*Ke |
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Term
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Definition
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Term
Calculating loading dose
Calculating maintenance dose |
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Definition
Loading dose = Desired plasma concentration*Vd/F
Maintenance: Desired plasma concentration*Cl/F |
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Term
| How must you adjust the loading and maintenance doses in liver or renal disease? |
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Definition
Loading dose unchanged
maintenance dose decreased |
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Term
| Drugs with zero order kinetics |
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Definition
PEA
Phenytoin
Ethanol
Aspirin |
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Term
| Examples of phase 1 and phase 2 metabolism |
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Definition
Phase 1 = p-450
Phase 2 = GAS (glucoronidation, acetylation, sulfation) |
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Term
| What happens to drug metabolism as we age? |
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Definition
Phase 1 decreases
Phase 2 stays constant |
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Term
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Definition
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