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1. Every year more than _____ million Americans are infected with STD’s. |
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2. The _____ is the number 1 industrialized nations in respect to the most cases of STD’s. |
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3. The highest concentration of HIV spread is through _____. |
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4. Which race is most commonly affected by HIV? |
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5. What was the number of people living with HIV in 2008? |
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6. How many newly infected HIV people were there in 2008? |
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7. How many AIDS deaths were there in 2008? |
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8. HIV infects the T helped cells because it has the protein _____ on its surface. |
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9. HIV needs to use CD4 to enter the cells it infects. Once inside a T helper cell, HIV takes advantage of the cellular machinery to make _____. |
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10. HIV particles surround themselves with a coat of fatty material known as the _____. |
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11. Projecting from the viral envelope, there are 72 little spikes which are formed from the proteins _____ and _____. |
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12. Just below the viral envelope is a layer called the matrix, which is made from the protein _____. |
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13. The viral core (or capsid) is usually bullet shaped, and is made from the protein _____. |
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14. Inside the core are these 3 enzymes required for HIV replication. |
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1) REVERSE TRANSCRIPTASE, 2) INTEGRASE, 3) PROTEASE |
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15. Also held within the core is HIV’s genetic material which consists of _____. |
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2 IDENTICAL STRANDS OF RNA |
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16. Dr. Robert Gallo of NCI found the cause of AIDS is the retrovirus _____. |
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17. What year was the first AIDS antibody test released? |
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18. What is the name of the first AIDS antibody test? |
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19. In 1987, the FDA approved _____ as the first antiretroviral drug to be used to treat AIDS. |
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20. In 1987, the FDA approved the first _____ blood test, which was a more specific HIV diagnostic test. |
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21. Which year did combination therapy with AZT arrive? |
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22. In 1995, this drug was released which is the first anti-HIV drug of the protease inhibitor class. |
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23. _____is an opportunistic infection that occurs in patients with advanced HIV. |
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PCP (PNEUMOCYSTIS CARINII PNEUMONIA) |
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24. The first sign of this condition is usually the development of skin lesions that begin as flat or slightly raised colored spots. |
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25. About 1-3 people with AIDS related Kaposi sarcoma will develop _____ and _____ lesions. |
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26. This state has the highest transmission rate of AIDS in the US. |
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27. There is substantial biological evidence demonstrating that the presence of other _____ increases the likelihood of both transmitting and acquiring HIV. |
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28. These 3 STD’s which cause genital ulcers result in breaks in the genital tract or skin lining which creates a portal of entry for HIV. |
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1) SYPHILIS, 2) HERPES, 3) CHANCROID |
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29. These 3 non-ulcerative STD’s increase the concentration of cells in genital secretions that can serve as targets for HIV. |
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1) CHLAMYDIA, 2) GONORRHEA, 3) TRICHOMONIASIS |
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30. The presence of an untreated STD can also increase the risk of both acquisition and transmission of HIV by a factor of up to _____. |
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31. These are the 4 stages of HIV infection. |
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1) SEROCONVERSION PERIOD, 2) ASYMPTOMATIC, 3) SYMPTOMATIC, 4) AIDS |
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32. What happens during the seroconverson/window period of HIV? |
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INFECTION WITH HIV, ANTIBODIES DEVELOP |
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33. What happens during the asymptomatic phase of HIV? |
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NO SIGNS OF HIV, IMMUNE SYSTEM CONTROLS VIRUS PRODUCTION |
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34. What happens during the symptomatic phase of HIV? |
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PHYSICAL SIGNS OF HIV INFECTION, WITH SOME IMMUNE SUPPRESSION |
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35. What happens when one has the AIDS stage of HIV? |
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36. 5 impacts of global HIV. |
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1) NEGATIVE ECONOMIC IMPACT ON COUNTRIES, 2) OVERSTRAINED HEALTHCARE SYSTEMS, 3) DECREASING LIFE EXPECTANCY, 4) REVERSAL OF CHILD SURVIVAL GAINS, 5) INCREASED NUMBERS OF ORPHANS |
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37. 5 public health strategies to prevent HIV transmission. |
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1) SCREEN ALL BLOOD AND BLOOD PRODUCTS, 2) FOLLOW UNIVERSAL PRECAUTIONS, 3) EDUCATE IN SAFER SEX PRACTICES, 4) IDENTIFY AND TREAT STD’S, 5) PROVIDE REFERRAL FOR TREATMENT OF DRUG DEPENDENCE |
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38. _____ is the number of copies of HIV in the blood. |
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39. HIV was originally called _____ because of the predilection to occur mainly in fagboys. |
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GAY-RELATED IMMUNE DISEASE |
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40. _____ was the name given to African AIDS patients because of the severe wasting that occurs in the later stages of the disease. |
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41. This opportunistic infections occurs then the CD4 count is less than 200. |
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42. What is a prevention for PCP? |
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43. These 2 opportunistic infections can occur when the CD4 t-cell count is less than 100. |
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1) TOXOPLASMOSIS, 2) CRYPTOCOCCUS |
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44. This opportunistic infection can occur when the CD4 t-cell count is less than 75. |
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MYCOBACTERIUM AVIUM COMPLEX |
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45. A lower CD4 t-cell count means decreasing _____. |
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46. A higher viral load in the blood means more _____. |
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47. Does social “closed mouth” kissing increase ones risk of contracting HIV? |
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48. Does “French” kissing increase ones risk of contracting HIV? |
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YES, BUT THE CHANCES OF SPREAD ARE EXTREMELY LOW |
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49. Is biting a common way of transmitting HIV? |
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50. Can HIV be spread through biting insects? |
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51. 3 times a mother can pass HIV onto her fetus/baby. |
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1) DURING PREGNANCY, 2) DURING DELIVERY, 3) THROUGH BREAST MILK |
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52. This is the 3-part AZT regimen during pregnancy. |
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1) WOMEN SHOULD TAKE AZY STARTING AT 14-34 WEEKS OF PREGNANCY, 2) DURING LABOR AND DELIVERY THE WOMEN SHOULD RECEIVE AZY INTRAVENOUSLY, 3) BABY SHOULD TAKE AZT EVERY 6 HOURS FOR 6 WEEKS AFTER HE OR SHE IS BORN |
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53. America’s most dramatic success in HIV prevention has been the reduction in transmission from _____. |
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54. The decline of HIV transmission from mother to child was through these 3 mechanisms. |
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1) ANTIRETROVIRAL DRUGS, 2) C-SECTION, 3) AVOIDANCE OF BRAST FEEDING |
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55. Who was the first public figure known to have died of AIDS? |
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56. What is the difference between HIV-1 and HIV-2? |
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HIV-2 IS LESS EASILY TRANSMITTED, AND THE PERIOD BETWEEN INITIAL INFECTION AND ILLNESS IS LONGER IN THE CASE OF HIV-2 |
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57. Which is more common HIV-1 or 2? |
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58. The relatively uncommon HIV-2 type is concentrated in _____, and is rarely found elsewhere. |
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59. Globally, most women become infected with HIV through these 3 mechanisms. |
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1) BLOOD TRANSFUSIONS, 2) UNPROTECTED HETEROSEXUAL SEX, 3) SEX WITH OTHER WOMEN, 4) SHARING NEEDLES |
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60. What does the standard HIV test identify? |
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61. There is less than a _____% chance that HIV will be transmitted from mother to child if the mother takes the correct drugs and does not breastfeed and c-section. |
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62. A _____ result on an HIV test means that HIV antibodies are present in your bloodstream and you are HIV-positive. |
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63. A _____ result on an HIV test indicates that you are not infected with HIV. |
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64. How often should you re-test for HIV if you have engaged in high-risk behavior during the past 6 months? |
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6 MONTHS, BECAUSE IT CAN TAKE THIS LONG FOR YOUR IMMUNE SYSTEM TO PRODUCE ENOUGH ANTIBODIES |
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65. A _____ test is available for HIV screening that produces results within 5-30min. |
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66. If an ELISA test shows the blood sample is positive for HIV, then a _____ is done to confirm the initial result. |
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67. Florida law 381.004 states that_____ must first be obtained before testing anyone for HIV and such consent must be preceded by an explanation about the right of confidential treatment, and that if positive that information must be shared with the county health department. |
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68. Can a physician break confidentiality when 3rd parties are at risk? |
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69. 3 things states by Florida state law 381.004. |
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1) INFORMED CONSENT MUST BE GIVEN, 2) IF HIV POSITIVE, SHATE THE RESULT WITH STATE HEALTH DEPARTMENT WITHIN 2 WEEKS, 3) MAY BREAK THE CONFIDENTIALITY OF 3RD PARTIES ARE AT RISK |
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70. These were the first drugs used for HIV inhibit viral RNA-dependent DNA polymerase (reverse transcriptase). |
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NUCLEOSIDE-ANALOG REVERSE TRANSCRIPTASE INHIBITORS (NRTI) (ZIDOVUDINE) |
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71. These were the 2nd HIV treating drugs inhibit HIV replication directly by binding non-competitively to reverse transcriptase. |
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NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS |
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72. These drugs are specific for the HIV-1 protease and competitively inhibit the enzyme, preventing the maturation of virions capable of infecting other cells. |
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PROTEASE INHIBITORS (SAQUINAVIR) |
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73. _____ is the first agent of the pharmacological class of antiretroviral agents known as HIV integrase inhibitors. When used with other anti-HIV medicines it may reduce the amount of HIV in the blood and may increase CD4 t-cells. |
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74. Which law requires you to offer HIV screening test for pregnant moms? |
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75. These 2 receptors are needed for HIV to enter a cell. |
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CD4 and CHEMOKINE CO-RECEPTOR |
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