Term
| 3 phases of tumor transformation |
|
Definition
-initiation
-promotion
-progression |
|
|
Term
| how does metastasis occur |
|
Definition
-intravasion (detachment of tumor cells that infiltrate into the lymph or blood)
-extravasion (reciprocal process in other parts of the body) |
|
|
Term
| what are the MC sites of cancer mets |
|
Definition
| brain, lymph nodes, respiratory, liver, skeletal |
|
|
Term
|
Definition
| drug induced tumor cell lysis |
|
|
Term
| blockade of tumor vasculature |
|
Definition
|
|
Term
| tumor cell lysis through selectively replicating virus |
|
Definition
|
|
Term
| restore/add or inhibit expression of particular genes in tumor cells |
|
Definition
|
|
Term
| what are the "bad" sun rays |
|
Definition
|
|
Term
| what are the "bad" sun rays |
|
Definition
|
|
Term
| what are the RF's for NMSC |
|
Definition
-blue/green eyes, burn easily, work outdoors
-high lifetime sun/UV exposure
-artificial tanning bads
-immunocompromised, HPV infxn, previous radiation exposure
-scarring from burns, elderly, fair skinned freckled, red hair |
|
|
Term
|
Definition
|
|
Term
| what are some other things the sun can cause |
|
Definition
-wrinkling
-telangiectasias
-AK
-solar elastosis |
|
|
Term
| what are some characteristics of malignant skin lesions |
|
Definition
-pigmentation change
-rapid growth, bleeding, crusting
-pain, pruritus
-raised borders, central ulceration
-serous exudate, regional LAD |
|
|
Term
| slowly non aggressive skin cancer that presents as nodular (smooth, dome shaped or round, pearly papule) w/ telangiectasias, bleeding, central necrosis |
|
Definition
|
|
Term
|
Definition
-<0.5 cm=cryotherapy, electrodissecation, curretage
-surgery w/ 1 cm margin is standard
-grafting |
|
|
Term
| when should we f/u after BCC |
|
Definition
|
|
Term
| what does cigarette smoking cause on the lip/mouth |
|
Definition
|
|
Term
| erythematous firm papule that forms a nodule w/ central ulceration, crusts, scabs |
|
Definition
|
|
Term
| what's the difference in tx for SCC than BCC |
|
Definition
| -lymph node dissection may be necessary |
|
|
Term
| surgery used for those areas where wide excision isn't possible |
|
Definition
|
|
Term
| what's the goal for MOH's |
|
Definition
| minimal damage to surrounding healthy tissue |
|
|
Term
| what does MOH's have the highest cure rate for |
|
Definition
|
|
Term
| greatest malignant potential |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what's the tx for melanoma |
|
Definition
-total lesion removal
-staging
-skin grafting
-sentinel node bx
-RT=brain mets |
|
|
Term
| dx and rx for non hodgkins |
|
Definition
|
|
Term
| where do sarcoma occur most |
|
Definition
|
|
Term
| what's the surgical resection margin for sarcoma |
|
Definition
|
|
